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Acrosin (EC 3.4.21.10) [Cleaved into: Acrosin light chain; Acrosin heavy chain] (Fragment)

 ACRO_CAPHI              Reviewed;          60 AA.
P10626;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
05-DEC-2018, entry version 96.
RecName: Full=Acrosin;
EC=3.4.21.10;
Contains:
RecName: Full=Acrosin light chain;
Contains:
RecName: Full=Acrosin heavy chain;
Flags: Fragment;
Name=ACR;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
PROTEIN SEQUENCE.
TISSUE=Sperm;
PubMed=2930460; DOI=10.1042/bj2570447;
Hardy D.M., Schoots A.F.M., Hedrick J.L.;
"Caprine acrosin. Purification, characterization and proteolysis of
the porcine zona pellucida.";
Biochem. J. 257:447-453(1989).
-!- FUNCTION: Acrosin is the major protease of mammalian spermatozoa.
It is a serine protease of trypsin-like cleavage specificity, it
is synthesized in a zymogen form, proacrosin and stored in the
acrosome.
-!- CATALYTIC ACTIVITY:
Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.;
EC=3.4.21.10;
-!- ACTIVITY REGULATION: Inhibited by SERPINA5. {ECO:0000250}.
-!- SUBUNIT: Heavy chain (catalytic) and a light chain linked by two
disulfide bonds. Forms a heterodimer with SERPINA5 (By
similarity). {ECO:0000250}.
-!- MISCELLANEOUS: X's in position 19 to 22 were introduced by
homology with the pig sequence.
-!- SIMILARITY: Belongs to the peptidase S1 family.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
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PIR; S02175; S02175.
PIR; S02176; S02176.
ProteinModelPortal; P10626; -.
MEROPS; S01.223; -.
GO; GO:0001669; C:acrosomal vesicle; IDA:CAFA.
GO; GO:0004040; F:amidase activity; ISS:UniProtKB.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0042806; F:fucose binding; ISS:UniProtKB.
GO; GO:0005537; F:mannose binding; ISS:UniProtKB.
GO; GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0007340; P:acrosome reaction; ISS:UniProtKB.
GO; GO:0007190; P:activation of adenylate cyclase activity; ISS:UniProtKB.
GO; GO:0007338; P:single fertilization; ISS:UniProtKB.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001254; Trypsin_dom.
Pfam; PF00089; Trypsin; 1.
SUPFAM; SSF50494; SSF50494; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase;
Protease; Serine protease; Zymogen.
CHAIN 1 23 Acrosin light chain.
/FTId=PRO_0000027516.
CHAIN 24 >60 Acrosin heavy chain.
/FTId=PRO_0000027517.
DOMAIN 24 >60 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
CARBOHYD 3 3 N-linked (GlcNAc...) asparagine.
DISULFID 6 6 Interchain (with heavy chain).
{ECO:0000305}.
DISULFID 10 10 Interchain (with heavy chain).
{ECO:0000305}.
NON_TER 60 60
SEQUENCE 60 AA; 6879 MW; BF76512CB2A86752 CRC64;
RDNTTCDGPC GIRFRQNRXX XXRIIGGQDA AHGSWPWMVS LQIFTYHNNR RYHVCGGSLL


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