Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Actin-depolymerizing factor 1, isoforms a/b (Uncoordinated protein 60)

 ADF1_CAEEL              Reviewed;         212 AA.
Q07750; Q9UAU4;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
05-SEP-2006, sequence version 2.
10-OCT-2018, entry version 130.
RecName: Full=Actin-depolymerizing factor 1, isoforms a/b;
AltName: Full=Uncoordinated protein 60;
Name=unc-60; ORFNames=C38C3.5;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8107682; DOI=10.1007/BF00280425;
McKim K.S., Matheson C., Marra M.A., Wakarchuk M.F., Baillie D.L.;
"The Caenorhabditis elegans unc-60 gene encodes proteins homologous to
a family of actin-binding proteins.";
Mol. Gen. Genet. 242:346-357(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION, AND INTERACTION WITH F-ACTIN.
PubMed=17684058; DOI=10.1242/jcs.013516;
Yamashiro S., Gimona M., Ono S.;
"UNC-87, a calponin-related protein in C. elegans, antagonizes
ADF/cofilin-mediated actin filament dynamics.";
J. Cell Sci. 120:3022-3033(2007).
-!- FUNCTION: Depolymerizes growing actin filaments in muscle cells;
required for the assembly of actin filaments into the functional
contractile myofilament lattice of muscle (PubMed:8107682).
Competes with unc-87 for actin binding and inhibits the actin-
bundling activity of unc-87 (PubMed:17684058).
{ECO:0000269|PubMed:17684058, ECO:0000303|PubMed:8107682}.
-!- SUBUNIT: Interacts with F-actin. {ECO:0000269|PubMed:17684058}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Comment=Isoforms only share an exon that codes for the initiator
Met.;
Name=b;
IsoId=Q07750-2; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=a; Synonyms=ADF1;
IsoId=Q07750-1; Sequence=VSP_020111, VSP_020112;
Name=c; Synonyms=ADF2;
IsoId=Q07749-1; Sequence=External;
-!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L18963; AAC14458.1; -; Genomic_DNA.
EMBL; FO080816; CCD67021.1; -; Genomic_DNA.
EMBL; FO080816; CCD67022.1; -; Genomic_DNA.
PIR; S41728; S41728.
RefSeq; NP_503425.2; NM_071024.5. [Q07750-1]
UniGene; Cel.17967; -.
PDB; 2MP4; NMR; -; A=1-156.
PDBsum; 2MP4; -.
ProteinModelPortal; Q07750; -.
SMR; Q07750; -.
BioGrid; 43707; 2.
IntAct; Q07750; 2.
STRING; 6239.C38C3.5b.1; -.
EPD; Q07750; -.
PaxDb; Q07750; -.
PeptideAtlas; Q07750; -.
PRIDE; Q07750; -.
EnsemblMetazoa; C38C3.5a.1; C38C3.5a.1; WBGene00006794. [Q07750-1]
EnsemblMetazoa; C38C3.5a.2; C38C3.5a.2; WBGene00006794. [Q07750-1]
GeneID; 178640; -.
UCSC; C38C3.5b.1; c. elegans. [Q07750-1]
CTD; 178640; -.
WormBase; C38C3.5a; CE20547; WBGene00006794; unc-60. [Q07750-1]
eggNOG; KOG1735; Eukaryota.
eggNOG; ENOG41122P5; LUCA.
HOGENOM; HOG000039697; -.
InParanoid; Q07750; -.
OrthoDB; EOG091G0TDH; -.
PhylomeDB; Q07750; -.
Proteomes; UP000001940; Chromosome V.
Bgee; WBGene00006794; Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans).
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:1990904; C:ribonucleoprotein complex; IPI:WormBase.
GO; GO:0005865; C:striated muscle thin filament; IDA:WormBase.
GO; GO:0051015; F:actin filament binding; IDA:WormBase.
GO; GO:0030042; P:actin filament depolymerization; IDA:WormBase.
GO; GO:0051014; P:actin filament severing; IDA:WormBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0040011; P:locomotion; IMP:WormBase.
GO; GO:0071689; P:muscle thin filament assembly; IMP:WormBase.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IDA:WormBase.
GO; GO:0030240; P:skeletal muscle thin filament assembly; IMP:WormBase.
CDD; cd11286; ADF_cofilin_like; 1.
Gene3D; 3.40.20.10; -; 2.
InterPro; IPR002108; ADF-H.
InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
InterPro; IPR017904; ADF/Cofilin.
PANTHER; PTHR11913; PTHR11913; 2.
Pfam; PF00241; Cofilin_ADF; 1.
SMART; SM00102; ADF; 1.
PROSITE; PS51263; ADF_H; 1.
1: Evidence at protein level;
3D-structure; Actin-binding; Alternative splicing; Complete proteome;
Reference proteome.
CHAIN 1 212 Actin-depolymerizing factor 1, isoforms
a/b.
/FTId=PRO_0000214938.
DOMAIN 3 159 ADF-H. {ECO:0000255|PROSITE-
ProRule:PRU00599}.
VAR_SEQ 157 165 NCPDNAPVR -> KLGEKYGDH (in isoform a).
{ECO:0000305}.
/FTId=VSP_020111.
VAR_SEQ 166 212 Missing (in isoform a). {ECO:0000305}.
/FTId=VSP_020112.
HELIX 10 19 {ECO:0000244|PDB:2MP4}.
TURN 20 22 {ECO:0000244|PDB:2MP4}.
STRAND 23 26 {ECO:0000244|PDB:2MP4}.
STRAND 28 33 {ECO:0000244|PDB:2MP4}.
STRAND 36 41 {ECO:0000244|PDB:2MP4}.
TURN 46 49 {ECO:0000244|PDB:2MP4}.
TURN 54 57 {ECO:0000244|PDB:2MP4}.
HELIX 60 73 {ECO:0000244|PDB:2MP4}.
TURN 74 77 {ECO:0000244|PDB:2MP4}.
STRAND 82 92 {ECO:0000244|PDB:2MP4}.
STRAND 98 109 {ECO:0000244|PDB:2MP4}.
HELIX 116 133 {ECO:0000244|PDB:2MP4}.
STRAND 139 143 {ECO:0000244|PDB:2MP4}.
HELIX 146 149 {ECO:0000244|PDB:2MP4}.
HELIX 151 156 {ECO:0000244|PDB:2MP4}.
SEQUENCE 212 AA; 23578 MW; 30616B9CC8F9D716 CRC64;
MSSGVMVDPD VQTSFQKLSE GRKEYRYIIF KIDENKVIVE AAVTQDQLGI TGDDYDDSSK
AAFDKFVEDV KSRTDNLTDC RYAVFDFKFT CSRVGAGTSK MDKIIFLQIC PDGASIKKKM
VYASSAAAIK TSLGTGKILQ FQVSDESEMS HKELLNNCPD NAPVRRRMLY ASSVRALKAS
LGLESLFQVQ ASEMSDLDEK SVKSDLMSNQ RI


Related products :

Catalog number Product name Quantity
30-394 DSTN belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. It is the actin depolymerizing protein that severs actin 0.05 mg
EIAAB10964 Actin-depolymerizing factor,ADF,Destrin,DSN,DSTN,Pig,Sus scrofa
gen6106 GELS_PIG Actin-depolymerizing factor ELISA tesk kit 1
gen6100 GELS_MOUSE Actin-depolymerizing factor ELISA tesk kit 1
gen6094 GELS_HUMAN Actin-depolymerizing factor ELISA tesk kit 1
gen6088 GELS_CHICK Actin-depolymerizing factor ELISA tesk kit 1
gen6083 GELS_BOVIN Actin-depolymerizing factor ELISA tesk kit 1
gen6111 GELS_RAT Actin-depolymerizing factor ELISA tesk kit 1
DTD1 DSTN Gene destrin (actin depolymerizing factor)
U0372p CLIA Actin-depolymerizing factor,ADF,Brevin,Gelsolin,GSN,Pig,Sus scrofa 96T
E0372p ELISA Actin-depolymerizing factor,ADF,Brevin,Gelsolin,GSN,Pig,Sus scrofa 96T
E0372p ELISA kit Actin-depolymerizing factor,ADF,Brevin,Gelsolin,GSN,Pig,Sus scrofa 96T
EIAAB10967 Actin-depolymerizing factor,ADF,Destrin,Dstn,Rat,Rattus norvegicus
EIAAB10963 Actin-depolymerizing factor,ADF,Bos taurus,Bovine,Destrin,DSTN
E0372r ELISA Actin-depolymerizing factor,ADF,Brevin,Gelsolin,Gsn,Rat,Rattus norvegicus 96T
U0372b CLIA Actin-depolymerizing factor,ADF,Bos taurus,Bovine,Brevin,Gelsolin,GSN 96T
EIAAB10966 Actin-depolymerizing factor,ADF,Destrin,Dsn,Dstn,Mouse,Mus musculus,Sid 23,Sid23
E0372m ELISA kit Actin-depolymerizing factor,ADF,Brevin,Gelsolin,Gsb,Gsn,Mouse,Mus musculus 96T
E0372b ELISA kit Actin-depolymerizing factor,ADF,Bos taurus,Bovine,Brevin,Gelsolin,GSN 96T
U0372m CLIA Actin-depolymerizing factor,ADF,Brevin,Gelsolin,Gsb,Gsn,Mouse,Mus musculus 96T
GS-0631a destrin (actin depolymerizing factor) primary antibody, Host: Rabbit 200ul
U0372r CLIA Actin-depolymerizing factor,ADF,Brevin,Gelsolin,Gsn,Rat,Rattus norvegicus 96T
E0372b ELISA Actin-depolymerizing factor,ADF,Bos taurus,Bovine,Brevin,Gelsolin,GSN 96T
E0372r ELISA kit Actin-depolymerizing factor,ADF,Brevin,Gelsolin,Gsn,Rat,Rattus norvegicus 96T
E0372m ELISA Actin-depolymerizing factor,ADF,Brevin,Gelsolin,Gsb,Gsn,Mouse,Mus musculus 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur