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Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA)

 AVR2A_BOVIN             Reviewed;         513 AA.
Q28043; A5D7L7;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
07-JUN-2017, entry version 143.
RecName: Full=Activin receptor type-2A;
EC=2.7.11.30;
AltName: Full=Activin receptor type IIA;
Short=ACTR-IIA;
Flags: Precursor;
Name=ACVR2A; Synonyms=ACTRII, ACVR2;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Holstein; TISSUE=Testis;
PubMed=7534730; DOI=10.1016/0303-7207(94)90179-1;
Ethier J.-F., Houde A., Lussier J.G., Silversides D.W.;
"Bovine activin receptor type II cDNA: cloning and tissue
expression.";
Mol. Cell. Endocrinol. 106:1-8(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
PubMed=8875905; DOI=10.1007/s003359900258;
Monteagudo L.V., Heriz A., Flavin N., Rogers M., Ennis S.,
Arruga M.V.;
"Fluorescent in situ localization of the bovine activin receptor type
IIA locus on chromosome 2 (2q2.3-2.4).";
Mamm. Genome 7:869-869(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Fetal muscle;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: On ligand binding, forms a receptor complex consisting
of two type II and two type I transmembrane serine/threonine
kinases. Type II receptors phosphorylate and activate type I
receptors which autophosphorylate, then bind and activate SMAD
transcriptional regulators. Receptor for activin A, activin B and
inhibin A. Mediates induction of adipogenesis by GDF6.
{ECO:0000250|UniProtKB:P27037, ECO:0000250|UniProtKB:P27038}.
-!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
protein] phosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- SUBUNIT: Interacts with AIP1. Part of a complex consisting of
AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
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EMBL; L21717; AAA74597.1; -; mRNA.
EMBL; U43208; AAC48694.1; -; mRNA.
EMBL; BC140605; AAI40606.1; -; mRNA.
PIR; I45850; I45850.
RefSeq; NP_776652.1; NM_174227.3.
UniGene; Bt.513; -.
ProteinModelPortal; Q28043; -.
SMR; Q28043; -.
STRING; 9913.ENSBTAP00000024108; -.
PaxDb; Q28043; -.
PRIDE; Q28043; -.
Ensembl; ENSBTAT00000024108; ENSBTAP00000024108; ENSBTAG00000018114.
GeneID; 281598; -.
KEGG; bta:281598; -.
CTD; 92; -.
eggNOG; KOG3653; Eukaryota.
eggNOG; ENOG410XS2Z; LUCA.
GeneTree; ENSGT00760000118876; -.
HOGENOM; HOG000231495; -.
HOVERGEN; HBG054502; -.
InParanoid; Q28043; -.
KO; K04670; -.
OMA; KRNHCYV; -.
OrthoDB; EOG091G03YO; -.
TreeFam; TF352876; -.
BRENDA; 2.7.10.2; 908.
Reactome; R-BTA-1502540; Signaling by Activin.
Reactome; R-BTA-201451; Signaling by BMP.
Proteomes; UP000009136; Chromosome 2.
Bgee; ENSBTAG00000018114; -.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0034673; C:inhibin-betaglycan-ActRII complex; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0048185; F:activin binding; IEA:Ensembl.
GO; GO:0017002; F:activin-activated receptor activity; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0098821; F:BMP receptor activity; ISS:UniProtKB.
GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
GO; GO:0019838; F:growth factor binding; IEA:Ensembl.
GO; GO:0034711; F:inhibin binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
GO; GO:0043621; F:protein self-association; IEA:Ensembl.
GO; GO:0004702; F:signal transducer, downstream of receptor, with serine/threonine kinase activity; IEA:InterPro.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
GO; GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl.
GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
GO; GO:0043084; P:penile erection; IEA:Ensembl.
GO; GO:0032927; P:positive regulation of activin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0030510; P:regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Ensembl.
GO; GO:0060011; P:Sertoli cell proliferation; IEA:Ensembl.
GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
InterPro; IPR000472; Activin_recp.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF01064; Activin_recp; 1.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR00653; ACTIVIN2R.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase;
Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding;
Receptor; Reference proteome; Serine/threonine-protein kinase; Signal;
Transferase; Transmembrane; Transmembrane helix.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 513 Activin receptor type-2A.
/FTId=PRO_0000024397.
TOPO_DOM 20 135 Extracellular. {ECO:0000255}.
TRANSMEM 136 161 Helical. {ECO:0000255}.
TOPO_DOM 162 513 Cytoplasmic. {ECO:0000255}.
DOMAIN 192 485 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 198 206 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 322 322 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 219 219 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 66 66 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 30 60 {ECO:0000250|UniProtKB:P27038}.
DISULFID 50 78 {ECO:0000250|UniProtKB:P27038}.
DISULFID 85 104 {ECO:0000250|UniProtKB:P27038}.
DISULFID 91 103 {ECO:0000250|UniProtKB:P27038}.
DISULFID 105 110 {ECO:0000250|UniProtKB:P27038}.
SEQUENCE 513 AA; 57952 MW; C2969A54CF00617B CRC64;
MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC
FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM
EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP
PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG
MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV
GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG
QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT
QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL


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