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Adenomatous polyposis coli

 F1QN37_DANRE            Unreviewed;      2752 AA.
F1QN37;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
20-JAN-2016, sequence version 2.
22-NOV-2017, entry version 58.
SubName: Full=Adenomatous polyposis coli {ECO:0000313|Ensembl:ENSDARP00000044431};
Name=apc {ECO:0000313|Ensembl:ENSDARP00000044431,
ECO:0000313|ZFIN:ZDB-GENE-031112-7};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000044431, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|Ensembl:ENSDARP00000044431}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000044431};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSDARP00000044431, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000044431,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSDARP00000044431}.
-----------------------------------------------------------------------
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EMBL; CU861476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CU915637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 7955.ENSDARP00000044431; -.
PaxDb; F1QN37; -.
PRIDE; F1QN37; -.
Ensembl; ENSDART00000044432; ENSDARP00000044431; ENSDARG00000058868.
ZFIN; ZDB-GENE-031112-7; apc.
eggNOG; KOG2122; Eukaryota.
eggNOG; ENOG410XR2V; LUCA.
GeneTree; ENSGT00530000063749; -.
InParanoid; F1QN37; -.
TreeFam; TF106496; -.
Reactome; R-DRE-111465; Apoptotic cleavage of cellular proteins.
Reactome; R-DRE-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-DRE-196299; Beta-catenin phosphorylation cascade.
Reactome; R-DRE-5689896; Ovarian tumor domain proteases.
Proteomes; UP000000437; Chromosome 10.
Bgee; ENSDARG00000058868; -.
ExpressionAtlas; F1QN37; baseline and differential.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0005634; C:nucleus; IEA:InterPro.
GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
GO; GO:0008017; F:microtubule binding; IEA:InterPro.
GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
GO; GO:0007050; P:cell cycle arrest; IEA:InterPro.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
GO; GO:0055123; P:digestive system development; IMP:ZFIN.
GO; GO:0048565; P:digestive tract development; IMP:ZFIN.
GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN.
GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0003157; P:endocardium development; IMP:ZFIN.
GO; GO:0031018; P:endocrine pancreas development; IMP:ZFIN.
GO; GO:0061031; P:endodermal digestive tract morphogenesis; IMP:ZFIN.
GO; GO:0030855; P:epithelial cell differentiation; IMP:ZFIN.
GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN.
GO; GO:0001754; P:eye photoreceptor cell differentiation; IMP:ZFIN.
GO; GO:0033334; P:fin morphogenesis; IMP:ZFIN.
GO; GO:0003146; P:heart jogging; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0003170; P:heart valve development; IMP:ZFIN.
GO; GO:0070365; P:hepatocyte differentiation; IMP:ZFIN.
GO; GO:0001889; P:liver development; IMP:ZFIN.
GO; GO:0030917; P:midbrain-hindbrain boundary development; IMP:ZFIN.
GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
GO; GO:0055001; P:muscle cell development; IGI:ZFIN.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:ZFIN.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:InterPro.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:InterPro.
GO; GO:0071599; P:otic vesicle development; IMP:ZFIN.
GO; GO:0031016; P:pancreas development; IMP:ZFIN.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
GO; GO:0048920; P:posterior lateral line neuromast primordium migration; IMP:ZFIN.
GO; GO:0044030; P:regulation of DNA methylation; IMP:ZFIN.
GO; GO:1900052; P:regulation of retinoic acid biosynthetic process; IGI:ZFIN.
GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:ZFIN.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IGI:ZFIN.
GO; GO:0001501; P:skeletal system development; IMP:ZFIN.
GO; GO:0061380; P:superior colliculus development; IMP:ZFIN.
GO; GO:0003306; P:Wnt signaling pathway involved in heart development; IMP:ZFIN.
GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IGI:ZFIN.
GO; GO:0022006; P:zona limitans intrathalamica formation; IMP:ZFIN.
Gene3D; 1.25.10.10; -; 2.
Gene3D; 4.10.900.10; -; 1.
InterPro; IPR026836; APC.
InterPro; IPR009240; APC_15aa_rpt.
InterPro; IPR009234; APC_basic_dom.
InterPro; IPR026831; APC_dom.
InterPro; IPR026818; Apc_fam.
InterPro; IPR032038; APC_N.
InterPro; IPR036149; APC_N_sf.
InterPro; IPR009223; APC_rpt.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000225; Armadillo.
InterPro; IPR027397; Catenin_binding_dom_sf.
InterPro; IPR009232; EB1-bd.
InterPro; IPR009224; SAMP.
PANTHER; PTHR12607; PTHR12607; 1.
PANTHER; PTHR12607:SF11; PTHR12607:SF11; 1.
Pfam; PF05972; APC_15aa; 2.
Pfam; PF05956; APC_basic; 1.
Pfam; PF16689; APC_N_CC; 1.
Pfam; PF05923; APC_r; 7.
Pfam; PF00514; Arm; 1.
Pfam; PF05937; EB1_binding; 1.
Pfam; PF05924; SAMP; 3.
SMART; SM00185; ARM; 7.
SUPFAM; SSF48371; SSF48371; 1.
SUPFAM; SSF58050; SSF58050; 1.
SUPFAM; SSF82931; SSF82931; 1.
PROSITE; PS50176; ARM_REPEAT; 1.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Proteomics identification {ECO:0000213|PeptideAtlas:F1QN37};
Reference proteome {ECO:0000313|Proteomes:UP000000437}.
DOMAIN 4 55 APC_N_CC. {ECO:0000259|Pfam:PF16689}.
REPEAT 652 694 ARM. {ECO:0000256|PROSITE-
ProRule:PRU00259}.
DOMAIN 2170 2511 APC_basic. {ECO:0000259|Pfam:PF05956}.
DOMAIN 2591 2746 EB1_binding. {ECO:0000259|Pfam:PF05937}.
COILED 6 54 {ECO:0000256|SAM:Coils}.
COILED 125 159 {ECO:0000256|SAM:Coils}.
SEQUENCE 2752 AA; 300793 MW; 67E3A781B948EF3D CRC64;
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLNKLETE ASNMKEVLKQ LQGSIDEDSK
DSQGQIEFLE RIKEMSLDPS GFSGVKLRSK ASLQGSADSS PSPSPVSSCP RRGASSGGRD
SAGYLEELEK ERSLLVAELE KEEKEKDWYY AQLQNLTKRI DSLPLTENFS LQTDMTRRQL
EYEARQIRAA MEDQLGTCQD MEKRAQGRVA RIQQIEKDML RIRTRLQAQS AESEVLRYST
TVKHEPLSQT EGSHAAGDAG AAAAASVCSQ GSASRVDHDS ASEMSSAGSY SVPRRLTSHL
GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR QSGCLPLLIQ LLHGNDKDSV
LLGNSRGSKE ARARASAALH NIIHSQPDDK RGRREIRVLH LLEQIRAYCE TCWEWQESHE
RGVDQDKNPM PSPVEHQICP AVCVLMKLSF DEEHRHAMNE LGGLQAIGEL LQVDCEIYGL
TNDHYSVTLR RYAGMALTNL TFGDVANKAT LCSMKGCMRA MVAQLKSESE DLQQVIASVL
RNLSWRADVN SKKILREVGS VRALMECALE VQKESTLKSV LSALWNLSAH CTENKADICT
VPGALAFLVS TLTYRSQTNT LAIIESGGGI LRNVSSLIAT NEEHRQILRE NSCLQTLLQH
LKSHSLTIVS NACGTLWNLS ARNAKDQEAL WDMGAVSMLK NLIHSKHKMI AMGSAAALRN
LMANRPAKYK DANIMSPGSS LPSLHVRKQK ALIEELDAQH LSETFDNIDN LSPKASHRVK
PRHKHNVYGD YDAVCRSDGY NPNGVGVRSP YMNTPVLSSP SSRDNRGNAE SVRAERDRSL
DRERRGFLPD GEAAKRMMQI PTSAAQIAVV MEEVQNMHLG MDDRSAGSTP DPHSVQDDMI
RRQTAVHGHQ NIYSYSKTDP SGRPCPMPKL EYRASNDSLN SVNSTDGYGK RGQMKPSVDS
YSEDDEGKCC VYRKYPADLA HKIHNANHME DDNGDLDTPI NYSLKYSDEQ LNSGRQSPSQ
NERWARPKLL DDEMKRPDQK PPRSQSPGYP MYTEGSSEGE DKPKKYQPRF VQQDLPAFRS
RGSNEQISSG SSHGLNKKIS QTICSVDDYA DDKPTNYSER YSEEEQLEEQ TPSYSMKYTE
DHHVEQPIDY SLKYSEAPSK KGMFSHSKTS SAQSSAKEHL SQDSSSSVAS LKNQGRQKQL
HPSSAQSRSG PTRAVQKNPT CKAPTINQET LQTYCVEDTP ICFSRGSSLS SLSSEEDEME
SCKRNVNSAS NYPTLPISEK QSTNNVAADQ RTSESQSSVH YVRAKPPRHH LGHGDGSRHH
KTVEFSSGAK SPSKSGAQTP KSPPEHYVQE TPLMFSRCTS VSSLDSFESH SIASSVQSEP
CSGMVSGIIS PSDLPDSPGQ TMPPSRSKTP PPPPPRSTSV KQKVTVPPHT EKHDLAPRHA
VVSAAVQKVQ VLPDNDTLLH FATESTPDGF SCASSLSALS LDEPFIQKDV ELKIMPPVHE
DDHSIEAEPE MEDMHEPKVQ EKSPATSEAA KDILDDSDDD DDTEILNACI NSAMPTKSSR
KPKKQSTSRI PPPVACKPSQ LPVYKLLPPQ NRGQPQKHVA LAHGEDMPRV YCVEGTPINF
STATSLSDLT IDSPPNELAG MESSAPHVEA SGQRRDTLPE GKSAEAKETG LSPPMQSALA
ENEGDDILAE CINSAMPKSK IHKPFRVQKM PDQAQHPSTA TGSLVQQDLE KKKPTSPVKP
MPQSSEYRAR MLKRPEANNS LADPATYPDK NKETRKQEPK VVIRDFADKP SNAEERTRPG
FAFDSPHHYT PIEGTPYCFS RNDSLSSLDF EDEDLDFSKE KAVLRKDKEQ RKVPLLKCSV
EQPANTNMVS TFQTAPTKPL QKTVFPQAPK ENTVVVCDEK QKFSIEDTPV CFSRNSSLSS
LSDIDQENNN KDCSHKDDVT QMEAPRPQAS GYAPKAFHVE DTPVCFSRNS SLSSLSIDSE
DDLLQECISS AMPKKKKQTP RSKTEESGVK EEKSMMADGI LSEEPDLILD LTDTHSPISE
QALSPDSESF DWKAIQEGAN SIVSSLHQAA ASLSRQGSSD SDSILSLKSG ISIGSPFHLP
LNQDDKPAPN KGPRILKPGE KSSIEAKKKE EETAKSLKGG KKVYKSLITG KPRPSLESMA
SQHRQAQAPV ISRGRTMVHV PGVRSSSPST SPVPKKPPPR GQMSKPPSQA PGAGSSPRTM
KVPPSSEPSP ASGPPSSQGG SSKASSRSGS RDSTPSRPVQ QSLTRPMQSP GRASVSPGRN
GLSPSNKLSQ LPQLPRTASP SASSTKSSGS GRMAYTSPGR QLVQPTPTKQ SGLPRSTSGI
PRSESASKIL NQCGPSKKAE LSRMSSTKSS GSESDRSEKP GLVRQSTFIK EAPSPTLKRK
LEESASFESL SPSSTSQSQT PVSSPSLPDM SLSLPYQGSG WTKAPQSQNS AENGDGKSLK
RHDISRSHSE SPSRLPINRT GTWKREHSKH SSSLPRVGTW KRTGSSSSIL SASSESSEKG
RSEDERQPTN PPQKSGKEGG LERKGTWRKA KGSETSYAPM SLDLQDQTGD AMSKSEDVWV
RIEDCPINNP RSSKSPTAST PPVIDSLPIK GLACDRDSSE SHSKLMSENA AMSHLGSETN
LNLLRSSESL DKKVTDIKPA PSNPNIGPEL HEFPVSERTP FSSTNSSKHS SPSGAVAARV
SPFNYTPSPR KSSADGSTPR PSQIPTPISS NAKKRDTKGD TTESGSYIVT SV


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