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Adenomatous polyposis coli

 F8W4Z3_DANRE            Unreviewed;      2745 AA.
F8W4Z3;
21-SEP-2011, integrated into UniProtKB/TrEMBL.
21-SEP-2011, sequence version 1.
30-AUG-2017, entry version 50.
SubName: Full=Adenomatous polyposis coli {ECO:0000313|Ensembl:ENSDARP00000123835};
Name=apc {ECO:0000313|Ensembl:ENSDARP00000123835,
ECO:0000313|ZFIN:ZDB-GENE-031112-7};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000123835, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|Ensembl:ENSDARP00000123835}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123835};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[2] {ECO:0000313|Ensembl:ENSDARP00000123835, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000123835,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSDARP00000123835}.
-----------------------------------------------------------------------
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EMBL; CU861476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CU915637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_005155580.1; XM_005155523.3.
RefSeq; XP_017213427.1; XM_017357938.1.
UniGene; Dr.160758; -.
UniGene; Dr.76198; -.
PaxDb; F8W4Z3; -.
Ensembl; ENSDART00000149956; ENSDARP00000123835; ENSDARG00000058868.
GeneID; 386762; -.
CTD; 324; -.
ZFIN; ZDB-GENE-031112-7; apc.
eggNOG; KOG2122; Eukaryota.
eggNOG; ENOG410XR2V; LUCA.
GeneTree; ENSGT00530000063749; -.
Reactome; R-DRE-111465; Apoptotic cleavage of cellular proteins.
Reactome; R-DRE-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-DRE-196299; Beta-catenin phosphorylation cascade.
Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
Reactome; R-DRE-5689896; Ovarian tumor domain proteases.
Proteomes; UP000000437; Chromosome 10.
Bgee; ENSDARG00000058868; -.
ExpressionAtlas; F8W4Z3; baseline and differential.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0005634; C:nucleus; IEA:InterPro.
GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
GO; GO:0008017; F:microtubule binding; IEA:InterPro.
GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
GO; GO:0007050; P:cell cycle arrest; IEA:InterPro.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
GO; GO:0055123; P:digestive system development; IMP:ZFIN.
GO; GO:0048565; P:digestive tract development; IMP:ZFIN.
GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN.
GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0003157; P:endocardium development; IMP:ZFIN.
GO; GO:0031018; P:endocrine pancreas development; IMP:ZFIN.
GO; GO:0061031; P:endodermal digestive tract morphogenesis; IMP:ZFIN.
GO; GO:0030855; P:epithelial cell differentiation; IMP:ZFIN.
GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN.
GO; GO:0001754; P:eye photoreceptor cell differentiation; IMP:ZFIN.
GO; GO:0033334; P:fin morphogenesis; IMP:ZFIN.
GO; GO:0003146; P:heart jogging; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0003170; P:heart valve development; IMP:ZFIN.
GO; GO:0070365; P:hepatocyte differentiation; IMP:ZFIN.
GO; GO:0001889; P:liver development; IMP:ZFIN.
GO; GO:0030917; P:midbrain-hindbrain boundary development; IMP:ZFIN.
GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
GO; GO:0055001; P:muscle cell development; IGI:ZFIN.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:ZFIN.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:InterPro.
GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:InterPro.
GO; GO:0071599; P:otic vesicle development; IMP:ZFIN.
GO; GO:0031016; P:pancreas development; IMP:ZFIN.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
GO; GO:0048920; P:posterior lateral line neuromast primordium migration; IMP:ZFIN.
GO; GO:0044030; P:regulation of DNA methylation; IMP:ZFIN.
GO; GO:1900052; P:regulation of retinoic acid biosynthetic process; IGI:ZFIN.
GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:ZFIN.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IGI:ZFIN.
GO; GO:0001501; P:skeletal system development; IMP:ZFIN.
GO; GO:0061380; P:superior colliculus development; IMP:ZFIN.
GO; GO:0003306; P:Wnt signaling pathway involved in heart development; IMP:ZFIN.
GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IGI:ZFIN.
GO; GO:0022006; P:zona limitans intrathalamica formation; IMP:ZFIN.
Gene3D; 1.25.10.10; -; 2.
Gene3D; 4.10.900.10; -; 1.
InterPro; IPR026836; APC.
InterPro; IPR009240; APC_15aa_rpt.
InterPro; IPR009234; APC_basic_dom.
InterPro; IPR026831; APC_dom.
InterPro; IPR026818; Apc_fam.
InterPro; IPR032038; APC_N.
InterPro; IPR009223; APC_rpt.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000225; Armadillo.
InterPro; IPR027397; Catenin_binding_dom.
InterPro; IPR009232; EB1-bd.
InterPro; IPR009224; SAMP.
PANTHER; PTHR12607; PTHR12607; 1.
PANTHER; PTHR12607:SF13; PTHR12607:SF13; 1.
Pfam; PF05972; APC_15aa; 2.
Pfam; PF05956; APC_basic; 1.
Pfam; PF16689; APC_N_CC; 1.
Pfam; PF05923; APC_r; 7.
Pfam; PF00514; Arm; 1.
Pfam; PF05937; EB1_binding; 1.
Pfam; PF05924; SAMP; 3.
SMART; SM00185; ARM; 7.
SUPFAM; SSF48371; SSF48371; 1.
SUPFAM; SSF58050; SSF58050; 1.
SUPFAM; SSF82931; SSF82931; 1.
PROSITE; PS50176; ARM_REPEAT; 1.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Proteomics identification {ECO:0000213|PeptideAtlas:F8W4Z3};
Reference proteome {ECO:0000313|Proteomes:UP000000437}.
DOMAIN 4 55 APC_N_CC. {ECO:0000259|Pfam:PF16689}.
REPEAT 645 687 ARM. {ECO:0000256|PROSITE-
ProRule:PRU00259}.
DOMAIN 2163 2504 APC_basic. {ECO:0000259|Pfam:PF05956}.
DOMAIN 2584 2739 EB1_binding. {ECO:0000259|Pfam:PF05937}.
COILED 6 54 {ECO:0000256|SAM:Coils}.
COILED 125 159 {ECO:0000256|SAM:Coils}.
SEQUENCE 2745 AA; 299972 MW; C6C846B25315C42B CRC64;
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLNKLETE ASNMKEVLKQ LQGSIDEDSK
DSQGQIEFLE RIKEMSLDPS GFSGVKLRSK ASLQGSADSS PSPSPVSSCP RRGASSGGRD
SAGYLEELEK ERSLLVAELE KEEKEKDWYY AQLQNLTKRI DSLPLTENFS LQTDMTRRQL
EYEARQIRAA MEDQLGTCQD MEKRAQGRVA RIQQIEKDML RIRTRLQAQS AESEVKHEPL
SQTEGSHAAG DAGAAAAASV CSQGSASRVD HDSASEMSSA GSYSVPRRLT SHLGTKVEMV
YSLLSMLGTH DKDDMSRTLL AMSSSQDSCI AMRQSGCLPL LIQLLHGNDK DSVLLGNSRG
SKEARARASA ALHNIIHSQP DDKRGRREIR VLHLLEQIRA YCETCWEWQE SHERGVDQDK
NPMPSPVEHQ ICPAVCVLMK LSFDEEHRHA MNELGGLQAI GELLQVDCEI YGLTNDHYSV
TLRRYAGMAL TNLTFGDVAN KATLCSMKGC MRAMVAQLKS ESEDLQQVIA SVLRNLSWRA
DVNSKKILRE VGSVRALMEC ALEVQKESTL KSVLSALWNL SAHCTENKAD ICTVPGALAF
LVSTLTYRSQ TNTLAIIESG GGILRNVSSL IATNEEHRQI LRENSCLQTL LQHLKSHSLT
IVSNACGTLW NLSARNAKDQ EALWDMGAVS MLKNLIHSKH KMIAMGSAAA LRNLMANRPA
KYKDANIMSP GSSLPSLHVR KQKALIEELD AQHLSETFDN IDNLSPKASH RVKPRHKHNV
YGDYDAVCRS DGYNPNGVGV RSPYMNTPVL SSPSSRDNRG NAESVRAERD RSLDRERRGF
LPDGEAAKRM MQIPTSAAQI AVVMEEVQNM HLGMDDRSAG STPDPHSVQD DMIRRQTAVH
GHQNIYSYSK TDPSGRPCPM PKLEYRASND SLNSVNSTDG YGKRGQMKPS VDSYSEDDEG
KCCVYRKYPA DLAHKIHNAN HMEDDNGDLD TPINYSLKYS DEQLNSGRQS PSQNERWARP
KLLDDEMKRP DQKPPRSQSP GYPMYTEGSS EGEDKPKKYQ PRFVQQDLPA FRSRGSNEQI
SSGSSHGLNK KISQTICSVD DYADDKPTNY SERYSEEEQL EEQTPSYSMK YTEDHHVEQP
IDYSLKYSEA PSKKGMFSHS KTSSAQSSAK EHLSQDSSSS VASLKNQGRQ KQLHPSSAQS
RSGPTRAVQK NPTCKAPTIN QETLQTYCVE DTPICFSRGS SLSSLSSEED EMESCKRNVN
SASNYPTLPI SEKQSTNNVA ADQRTSESQS SVHYVRAKPP RHHLGHGDGS RHHKTVEFSS
GAKSPSKSGA QTPKSPPEHY VQETPLMFSR CTSVSSLDSF ESHSIASSVQ SEPCSGMVSG
IISPSDLPDS PGQTMPPSRS KTPPPPPPRS TSVKQKVTVP PHTEKHDLAP RHAVVSAAVQ
KVQVLPDNDT LLHFATESTP DGFSCASSLS ALSLDEPFIQ KDVELKIMPP VHEDDHSIEA
EPEMEDMHEP KVQEKSPATS EAAKDILDDS DDDDDTEILN ACINSAMPTK SSRKPKKQST
SRIPPPVACK PSQLPVYKLL PPQNRGQPQK HVALAHGEDM PRVYCVEGTP INFSTATSLS
DLTIDSPPNE LAGMESSAPH VEASGQRRDT LPEGKSAEAK ETGLSPPMQS ALAENEGDDI
LAECINSAMP KSKIHKPFRV QKMPDQAQHP STATGSLVQQ DLEKKKPTSP VKPMPQSSEY
RARMLKRPEA NNSLADPATY PDKNKETRKQ EPKVVIRDFA DKPSNAEERT RPGFAFDSPH
HYTPIEGTPY CFSRNDSLSS LDFEDEDLDF SKEKAVLRKD KEQRKVPLLK CSVEQPANTN
MVSTFQTAPT KPLQKTVFPQ APKENTVVVC DEKQKFSIED TPVCFSRNSS LSSLSDIDQE
NNNKDCSHKD DVTQMEAPRP QASGYAPKAF HVEDTPVCFS RNSSLSSLSI DSEDDLLQEC
ISSAMPKKKK QTPRSKTEES GVKEEKSMMA DGILSEEPDL ILDLTDTHSP ISEQALSPDS
ESFDWKAIQE GANSIVSSLH QAAASLSRQG SSDSDSILSL KSGISIGSPF HLPLNQDDKP
APNKGPRILK PGEKSSIEAK KKEEETAKSL KGGKKVYKSL ITGKPRPSLE SMASQHRQAQ
APVISRGRTM VHVPGVRSSS PSTSPVPKKP PPRGQMSKPP SQAPGAGSSP RTMKVPPSSE
PSPASGPPSS QGGSSKASSR SGSRDSTPSR PVQQSLTRPM QSPGRASVSP GRNGLSPSNK
LSQLPQLPRT ASPSASSTKS SGSGRMAYTS PGRQLVQPTP TKQSGLPRST SGIPRSESAS
KILNQCGPSK KAELSRMSST KSSGSESDRS EKPGLVRQST FIKEAPSPTL KRKLEESASF
ESLSPSSTSQ SQTPVSSPSL PDMSLSLPYQ GSGWTKAPQS QNSAENGDGK SLKRHDISRS
HSESPSRLPI NRTGTWKREH SKHSSSLPRV GTWKRTGSSS SILSASSESS EKGRSEDERQ
PTNPPQKSGK EGGLERKGTW RKAKGSETSY APMSLDLQDQ TGDAMSKSED VWVRIEDCPI
NNPRSSKSPT ASTPPVIDSL PIKGLACDRD SSESHSKLMS ENAAMSHLGS ETNLNLLRSS
ESLDKKVTDI KPAPSNPNIG PELHEFPVSE RTPFSSTNSS KHSSPSGAVA ARVSPFNYTP
SPRKSSADGS TPRPSQIPTP ISSNAKKRDT KGDTTESGSY IVTSV


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