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Adenosine receptor A2a

 AA2AR_RAT               Reviewed;         410 AA.
P30543;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
31-JAN-2018, entry version 152.
RecName: Full=Adenosine receptor A2a;
Name=Adora2a;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=1599465;
Chern Y., King K., Lai H.-L., Lai H.-T.;
"Molecular cloning of a novel adenosine receptor gene from rat
brain.";
Biochem. Biophys. Res. Commun. 185:304-309(1992).
[2]
SEQUENCE REVISION TO 183.
TISSUE=Brain;
Chern Y.;
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Corpus striatum;
PubMed=1279342; DOI=10.1016/0169-328X(92)90173-9;
Fink J.S., Weaver D.R., Rivkees S.A., Peterfreund R.A., Pollack A.E.,
Adler E.M., Reppert S.M.;
"Molecular cloning of the rat A2 adenosine receptor: selective co-
expression with D2 dopamine receptors in rat striatum.";
Brain Res. Mol. Brain Res. 14:186-195(1992).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
Yip L., Hewitt J., Kwok Y.;
"Rattus norvegicus mucosa A2A adenosine receptor mRNA.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
SUBCELLULAR LOCATION.
PubMed=16339847; DOI=10.1124/mol.105.015818;
Milojevic T., Reiterer V., Stefan E., Korkhov V.M., Dorostkar M.M.,
Ducza E., Ogris E., Boehm S., Freissmuth M., Nanoff C.;
"The ubiquitin-specific protease Usp4 regulates the cell surface level
of the A2A receptor.";
Mol. Pharmacol. 69:1083-1094(2006).
-!- FUNCTION: Receptor for adenosine. The activity of this receptor is
mediated by G proteins which activate adenylyl cyclase.
-!- SUBUNIT: Interacts (via cytoplasmic C-terminal domain) with USP4;
the interaction is direct. May interact with DRD4. Interacts with
NECAB2 (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P29274}.
-!- INTERACTION:
P20272:Cnr1; NbExp=3; IntAct=EBI-2902822, EBI-2909800;
Q9QZE7:Tsnax (xeno); NbExp=6; IntAct=EBI-2902822, EBI-2910751;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16339847};
Multi-pass membrane protein {ECO:0000269|PubMed:16339847}.
-!- DOMAIN: The cytoplasmic C-terminal domain is necessary for
targeting the non-ubiquitinated form of this protein to the cell
surface. {ECO:0000250}.
-!- PTM: Ubiquitinated. Deubiquitinated by USP4; leading to
stabilization and expression at the cell surface (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; M91214; AAA70305.2; -; mRNA.
EMBL; L08102; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; S47609; AAA11888.1; -; mRNA.
EMBL; AF228684; AAF61924.1; -; mRNA.
EMBL; BC081727; AAH81727.1; -; mRNA.
PIR; A48974; A48974.
RefSeq; NP_445746.3; NM_053294.4.
RefSeq; XP_017457041.1; XM_017601552.1.
RefSeq; XP_017457042.1; XM_017601553.1.
RefSeq; XP_017457043.1; XM_017601554.1.
RefSeq; XP_017457044.1; XM_017601555.1.
UniGene; Rn.11180; -.
ProteinModelPortal; P30543; -.
SMR; P30543; -.
BioGrid; 247408; 2.
IntAct; P30543; 6.
MINT; MINT-269383; -.
STRING; 10116.ENSRNOP00000001759; -.
BindingDB; P30543; -.
ChEMBL; CHEMBL302; -.
GuidetoPHARMACOLOGY; 19; -.
PhosphoSitePlus; P30543; -.
PaxDb; P30543; -.
PRIDE; P30543; -.
Ensembl; ENSRNOT00000001759; ENSRNOP00000001759; ENSRNOG00000001302.
GeneID; 25369; -.
KEGG; rno:25369; -.
UCSC; RGD:2049; rat.
CTD; 135; -.
RGD; 2049; Adora2a.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00550000074524; -.
HOGENOM; HOG000015770; -.
HOVERGEN; HBG106962; -.
InParanoid; P30543; -.
KO; K04266; -.
OMA; MESQPLP; -.
OrthoDB; EOG091G0I3U; -.
PhylomeDB; P30543; -.
TreeFam; TF325296; -.
Reactome; R-RNO-417973; Adenosine P1 receptors.
Reactome; R-RNO-418555; G alpha (s) signalling events.
Reactome; R-RNO-5683826; Surfactant metabolism.
PRO; PR:P30543; -.
Proteomes; UP000002494; Chromosome 20.
Bgee; ENSRNOG00000001302; -.
Genevisible; P30543; RN.
GO; GO:0032279; C:asymmetric synapse; IDA:RGD.
GO; GO:0030673; C:axolemma; IDA:RGD.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0012505; C:endomembrane system; IDA:RGD.
GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO-UCL.
GO; GO:0099056; C:integral component of presynaptic membrane; IDA:SynGO-UCL.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0014069; C:postsynaptic density; IDA:RGD.
GO; GO:0045211; C:postsynaptic membrane; IDA:RGD.
GO; GO:0048786; C:presynaptic active zone; IDA:RGD.
GO; GO:0042734; C:presynaptic membrane; IDA:RGD.
GO; GO:0051393; F:alpha-actinin binding; IDA:RGD.
GO; GO:0019899; F:enzyme binding; ISO:RGD.
GO; GO:0001609; F:G-protein coupled adenosine receptor activity; IDA:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD.
GO; GO:0031802; F:type 5 metabotropic glutamate receptor binding; IPI:RGD.
GO; GO:0001973; P:adenosine receptor signaling pathway; IDA:RGD.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IMP:RGD.
GO; GO:0048143; P:astrocyte activation; IMP:RGD.
GO; GO:0042755; P:eating behavior; IMP:RGD.
GO; GO:0060079; P:excitatory postsynaptic potential; IDA:RGD.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISO:RGD.
GO; GO:0060080; P:inhibitory postsynaptic potential; ISO:RGD.
GO; GO:0007626; P:locomotory behavior; IMP:RGD.
GO; GO:0051899; P:membrane depolarization; IMP:RGD.
GO; GO:0046636; P:negative regulation of alpha-beta T cell activation; ISO:RGD.
GO; GO:0008285; P:negative regulation of cell proliferation; IDA:RGD.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:RGD.
GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
GO; GO:0040013; P:negative regulation of locomotion; IDA:RGD.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IDA:RGD.
GO; GO:0006469; P:negative regulation of protein kinase activity; IDA:RGD.
GO; GO:0043116; P:negative regulation of vascular permeability; IMP:RGD.
GO; GO:0048812; P:neuron projection morphogenesis; IDA:RGD.
GO; GO:0014057; P:positive regulation of acetylcholine secretion, neurotransmission; IMP:RGD.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISO:RGD.
GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; ISO:RGD.
GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IDA:RGD.
GO; GO:0014049; P:positive regulation of glutamate secretion; IDA:RGD.
GO; GO:0050714; P:positive regulation of protein secretion; IDA:RGD.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IDA:RGD.
GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; ISO:RGD.
GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IDA:RGD.
GO; GO:0035810; P:positive regulation of urine volume; IMP:RGD.
GO; GO:0060134; P:prepulse inhibition; IMP:RGD.
GO; GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IDA:RGD.
GO; GO:0051924; P:regulation of calcium ion transport; IMP:RGD.
GO; GO:0051881; P:regulation of mitochondrial membrane potential; IDA:RGD.
GO; GO:0014061; P:regulation of norepinephrine secretion; IMP:RGD.
GO; GO:0048167; P:regulation of synaptic plasticity; IDA:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:RGD.
GO; GO:0043279; P:response to alkaloid; IMP:RGD.
GO; GO:0001975; P:response to amphetamine; ISO:RGD.
GO; GO:0031000; P:response to caffeine; IDA:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0007271; P:synaptic transmission, cholinergic; IMP:RGD.
GO; GO:0001963; P:synaptic transmission, dopaminergic; ISO:RGD.
GO; GO:0035249; P:synaptic transmission, glutamatergic; IDA:RGD.
GO; GO:0042311; P:vasodilation; IMP:RGD.
CDD; cd15068; 7tmA_Adenosine_R_A2A; 1.
InterPro; IPR001513; Adeno_A2A_rcpt.
InterPro; IPR001634; Adenosn_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00553; ADENOSINA2AR.
PRINTS; PR00424; ADENOSINER.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix;
Ubl conjugation.
CHAIN 1 410 Adenosine receptor A2a.
/FTId=PRO_0000069001.
TOPO_DOM 1 4 Extracellular. {ECO:0000250}.
TRANSMEM 5 29 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 30 39 Cytoplasmic. {ECO:0000250}.
TRANSMEM 40 63 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 64 74 Extracellular. {ECO:0000250}.
TRANSMEM 75 97 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 98 117 Cytoplasmic. {ECO:0000250}.
TRANSMEM 118 140 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 141 168 Extracellular. {ECO:0000250}.
TRANSMEM 169 193 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 194 229 Cytoplasmic. {ECO:0000250}.
TRANSMEM 230 253 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 254 261 Extracellular. {ECO:0000250}.
TRANSMEM 262 285 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 286 410 Cytoplasmic. {ECO:0000250}.
REGION 163 172 Agonist binding. {ECO:0000250}.
REGION 241 248 Agonist binding. {ECO:0000250}.
REGION 259 269 Agonist binding. {ECO:0000250}.
CARBOHYD 142 142 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 149 149 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 68 154 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 71 143 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 74 161 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 254 257 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 268 268 A -> T (in Ref. 1; AAA70305).
{ECO:0000305}.
SEQUENCE 410 AA; 44999 MW; D87B256CD2336BAC CRC64;
MGSSVYITVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI AVGVLAIPFA
ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLAIAIDRY IAIRIPLRYN GLVTGVRAKG
IIAICWVLSF AIGLTPMLGW NNCSQKDGNS TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF
VLLPLLLMLA IYLRIFLAAR RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC
WLPLHIINCF TFFCSTCRHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT
HVLRRQEPFQ AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSATHSG RRPNGYTLGL
GGGGSAQGSP RDVELPTQER QEGQEHPGLR GHLVQARVGA SSWSSEFAPS


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