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Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26) (Cobalamin synthase) (Cobalamin-5'-phosphate synthase)

 Q1PJ68_PROMR            Unreviewed;       245 AA.
Q1PJ68;
16-MAY-2006, integrated into UniProtKB/TrEMBL.
16-MAY-2006, sequence version 1.
27-SEP-2017, entry version 42.
RecName: Full=Adenosylcobinamide-GDP ribazoletransferase {ECO:0000256|HAMAP-Rule:MF_00719, ECO:0000256|SAAS:SAAS00702411};
EC=2.7.8.26 {ECO:0000256|HAMAP-Rule:MF_00719, ECO:0000256|SAAS:SAAS00702417};
AltName: Full=Cobalamin synthase {ECO:0000256|HAMAP-Rule:MF_00719};
AltName: Full=Cobalamin-5'-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00719};
Name=CobS {ECO:0000313|EMBL:ABE11518.1};
Synonyms=cobS {ECO:0000256|HAMAP-Rule:MF_00719};
ORFNames=HOT0M-8G12_0010 {ECO:0000313|EMBL:ABE11518.1};
uncultured Prochlorococcus marinus clone HOT0M-8G12.
Bacteria; Cyanobacteria; Synechococcales; Prochloraceae;
Prochlorococcus.
NCBI_TaxID=379396 {ECO:0000313|EMBL:ABE11518.1};
[1] {ECO:0000313|EMBL:ABE11518.1}
NUCLEOTIDE SEQUENCE.
PubMed=16556843; DOI=10.1126/science.1122050;
Coleman M.L., Sullivan M.B., Martiny A.C., Steglich C., Barry K.,
Delong E.F., Chisholm S.W.;
"Genomic islands and the ecology and evolution of Prochlorococcus.";
Science 311:1768-1770(2006).
[2] {ECO:0000313|EMBL:ABE11518.1}
NUCLEOTIDE SEQUENCE.
US DOE Joint Genome Institute (JGI);
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
Hammon N., Israni S., Richardson P.;
"Sequencing of the draft fosmids and assembly of Prochlorococcus
marinus environmental genome fragment.";
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Joins adenosylcobinamide-GDP and alpha-ribazole to
generate adenosylcobalamin (Ado-cobalamin). Also synthesizes
adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and
alpha-ribazole 5'-phosphate. {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702400}.
-!- CATALYTIC ACTIVITY: Adenosylcobinamide-GDP + alpha-ribazole 5'-
phosphate = GMP + adenosylcobalamin 5'-phosphate.
{ECO:0000256|HAMAP-Rule:MF_00719, ECO:0000256|SAAS:SAAS00702415}.
-!- CATALYTIC ACTIVITY: Adenosylcobinamide-GDP + alpha-ribazole = GMP
+ adenosylcobalamin. {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702445}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702435};
-!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.
{ECO:0000256|HAMAP-Rule:MF_00719, ECO:0000256|SAAS:SAAS00702428}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
Rule:MF_00719}; Multi-pass membrane protein {ECO:0000256|HAMAP-
Rule:MF_00719}.
-!- SIMILARITY: Belongs to the CobS family. {ECO:0000256|HAMAP-
Rule:MF_00719, ECO:0000256|SAAS:SAAS00702395}.
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EMBL; DQ366744; ABE11518.1; -; Genomic_DNA.
UniPathway; UPA00148; UER00238.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0051073; F:adenosylcobinamide-GDP ribazoletransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0008818; F:cobalamin 5'-phosphate synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniRule.
HAMAP; MF_00719; CobS; 1.
InterPro; IPR003805; CobS.
PANTHER; PTHR34148; PTHR34148; 1.
Pfam; PF02654; CobS; 1.
3: Inferred from homology;
Cell membrane {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702407};
Cobalamin biosynthesis {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702420};
Magnesium {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702394};
Membrane {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702402, ECO:0000256|SAAS:SAAS00702407};
Transferase {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702398};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702402};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00719,
ECO:0000256|SAAS:SAAS00702402}.
TRANSMEM 27 46 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
TRANSMEM 52 73 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
TRANSMEM 99 119 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
TRANSMEM 125 144 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
TRANSMEM 165 186 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
TRANSMEM 192 211 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
TRANSMEM 223 244 Helical. {ECO:0000256|HAMAP-
Rule:MF_00719}.
SEQUENCE 245 AA; 27538 MW; 1727ECAE1C5429A4 CRC64;
MAGSWMFYTT FPKIPFINPE FKNIAQFAPL LGFFIGTIQS YIFIFLKANS WSIYASALIC
LASGYLITGG LHLDGLMDTF DGIFAGKKRR LKAMKDSKVG SFGVQSLVFI TLIQIACLLK
IQTQILTVLP ICLFWGRFSN LFFIEKFKYV SYKKKSISHK KFWNGFKKES LISIVFILIF
ITYQLVSITS HALLVKFLFI ILISIFLSYS IPNILGNKIG GFNGDACGAS VVLVETATLF
IYAIL


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