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Adenovirus death protein (ADP) (Early-3 11.6 kDa glycoprotein) (E3-11.6K)

 ADP_ADE02               Reviewed;         101 AA.
P24935;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
10-MAY-2017, entry version 75.
RecName: Full=Adenovirus death protein;
Short=ADP;
AltName: Full=Early-3 11.6 kDa glycoprotein;
Short=E3-11.6K;
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2).
Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus.
NCBI_TaxID=10515;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6253880; DOI=10.1093/nar/8.10.2173;
Herisse J., Courtois G., Galibert F.;
"Nucleotide sequence of the EcoRI D fragment of adenovirus 2 genome.";
Nucleic Acids Res. 8:2173-2192(1980).
[2]
IDENTIFICATION, AND SUBCELLULAR LOCATION.
PubMed=1448922; DOI=10.1016/0042-6822(92)90250-S;
Scaria A., Tollefson A.E., Saha S.K., Wold W.S.M.;
"The E3-11.6K protein of adenovirus is an Asn-glycosylated integral
membrane protein that localizes to the nuclear membrane.";
Virology 191:743-753(1992).
[3]
PALMITOYLATION.
PubMed=9601505; DOI=10.1006/viro.1998.9135;
Hausmann J., Ortmann D., Witt E., Veit M., Seidel W.;
"Adenovirus death protein, a transmembrane protein encoded in the E3
region, is palmitoylated at the cytoplasmic tail.";
Virology 244:343-351(1998).
[4]
INTERACTION WITH HOST MAD2L2/MAD2B.
PubMed=12951035; DOI=10.1016/S0042-6822(03)00287-3;
Ying B., Wold W.S.M.;
"Adenovirus ADP protein (E3-11.6K), which is required for efficient
cell lysis and virus release, interacts with human MAD2B.";
Virology 313:224-234(2003).
[5]
FUNCTION.
STRAIN=Human adenovirus C serotype 5;
PubMed=24198418; DOI=10.1128/JVI.01675-13;
Murali V.K., Ornelles D.A., Gooding L.R., Wilms H.T., Huang W.,
Tollefson A.E., Wold W.S., Garnett-Benson C.;
"Adenovirus death protein (ADP) is required for lytic infection of
human lymphocytes.";
J. Virol. 88:903-912(2014).
-!- FUNCTION: Promotes the release of progeny virus from the host cell
nucleus by accelerating the lysis and death of the host cell.
{ECO:0000269|PubMed:24198418}.
-!- SUBUNIT: May interact with host MAD2L2/MAD2B.
{ECO:0000269|PubMed:12951035}.
-!- SUBCELLULAR LOCATION: Host nucleus membrane; Single-pass type I
membrane protein {ECO:0000269|PubMed:1448922}. Host endoplasmic
reticulum membrane; Single-pass type I membrane protein
{ECO:0000269|PubMed:1448922}. Host Golgi apparatus membrane;
Single-pass type I membrane protein {ECO:0000269|PubMed:1448922}.
Note=Initially associates with the endoplasmic reticulum and Golgi
apparatus and ultimately localizes to the nuclear membrane.
{ECO:0000269|PubMed:1448922}.
-!- PTM: Glycosylated by host.
-!- PTM: Palmitoylated at cytoplasmic tail.
{ECO:0000269|PubMed:9601505}.
-!- SIMILARITY: Belongs to the adenoviridae ADP family. {ECO:0000305}.
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EMBL; J01917; AAA92222.1; -; Genomic_DNA.
RefSeq; AP_000185.1; AC_000007.1.
RefSeq; NP_040532.1; NC_001405.1.
MINT; MINT-273006; -.
GeneID; 2652987; -.
OrthoDB; VOG090001S5; -.
Proteomes; UP000008167; Genome.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0044200; C:host cell nuclear membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044659; P:cytolysis by virus of host cell; IDA:UniProtKB.
InterPro; IPR008652; Adenovirus_Type-2_E3A.
Pfam; PF05393; Hum_adeno_E3A; 1.
ProDom; PD015371; Hum_adeno_E3A; 1.
1: Evidence at protein level;
Complete proteome; Early protein; Glycoprotein;
Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
Host nucleus; Lipoprotein; Membrane; Palmitate; Reference proteome;
Transmembrane; Transmembrane helix.
CHAIN 1 101 Adenovirus death protein.
/FTId=PRO_0000221736.
TOPO_DOM 1 40 Extracellular. {ECO:0000255}.
TRANSMEM 41 62 Helical. {ECO:0000255}.
TOPO_DOM 63 101 Cytoplasmic. {ECO:0000255}.
CARBOHYD 14 14 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
SEQUENCE 101 AA; 11644 MW; FB89FCC6E921E84B CRC64;
MTGSTIAPTT DYRNTTATGL TSALNLPQVH AFVNDWASLD MWWFSIALMF VCLIIMWLIC
CLKRRRARPP IYRPIIVLNP HNEKIHRLDG LKPCSLLLQY D


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