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Adherens junction-associated protein 1

 AJAP1_RAT               Reviewed;         411 AA.
Q4W8E7;
17-APR-2007, integrated into UniProtKB/Swiss-Prot.
05-JUL-2005, sequence version 1.
18-JUL-2018, entry version 51.
RecName: Full=Adherens junction-associated protein 1;
Name=Ajap1; Synonyms=Neumo48;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Ishii S., Watanabe M., Kanbara K., Hayasaki H., Hayashi H.,
Kagamiyama H.;
"Characterization of a novel gene from rat brain, Neumo48, that
induces morphological changes when overexpressed.";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays a role in cell adhesion and cell migration.
{ECO:0000250}.
-!- SUBUNIT: Forms a complex with CDH1 and CTNNB1; interacts directly
with CTNNB1. Interacts with AP1M2 and BSG/CD147 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250};
Single-pass type III membrane protein {ECO:0000250}. Apical cell
membrane {ECO:0000250}; Single-pass type III membrane protein
{ECO:0000250}. Cell junction, adherens junction {ECO:0000250}.
Note=Mainly basolateral. Localization is mediated by AP1M2 (By
similarity). {ECO:0000250}.
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EMBL; AB179740; BAD98504.1; -; mRNA.
RefSeq; NP_001094484.1; NM_001101014.1.
UniGene; Rn.202629; -.
SMR; Q4W8E7; -.
STRING; 10116.ENSRNOP00000064502; -.
iPTMnet; Q4W8E7; -.
PhosphoSitePlus; Q4W8E7; -.
PaxDb; Q4W8E7; -.
PRIDE; Q4W8E7; -.
GeneID; 687031; -.
KEGG; rno:687031; -.
CTD; 55966; -.
RGD; 1590138; Ajap1.
eggNOG; ENOG410IHN1; Eukaryota.
eggNOG; ENOG410YW4K; LUCA.
HOVERGEN; HBG096853; -.
InParanoid; Q4W8E7; -.
KO; K21387; -.
PhylomeDB; Q4W8E7; -.
PRO; PR:Q4W8E7; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
InterPro; IPR039239; AJAP1.
InterPro; IPR029198; AJAP1_PANP_C.
PANTHER; PTHR32422; PTHR32422; 1.
Pfam; PF15298; AJAP1_PANP_C; 1.
2: Evidence at transcript level;
Cell adhesion; Cell junction; Cell membrane; Complete proteome;
Membrane; Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 411 Adherens junction-associated protein 1.
/FTId=PRO_0000284803.
TOPO_DOM 1 283 Extracellular. {ECO:0000255}.
TRANSMEM 284 304 Helical. {ECO:0000255}.
TOPO_DOM 305 411 Cytoplasmic. {ECO:0000255}.
REGION 304 411 Targeting signals. {ECO:0000250}.
COMPBIAS 174 258 Thr-rich.
SEQUENCE 411 AA; 44755 MW; 28533B826DD95FE9 CRC64;
MWIQQLLGLS SMPIRWPGRS LGSHLWILIA MLQLAVDFPS CDSLGPGPEF RLLSRPQRPQ
RLWSLRTGPP TRLPTPAWSP RAARAERAHG PIQMQTPRAR RAHRPRDQVA TLGPKGGLTK
PPAATRSSPS LTSASASSSM TAGAAEHQSL LKRGRRHTHD AEFNDFDFHG GRPTTETEFI
AWGPTGDEEA LESNTFPGGF GPTTVSILQT RKTTMAATTT TTAASTATAM TLQTKGVTES
LDPWKRTPVG VSTTEPSTSP SNNGKDIQPP RILGETSGLA VHQIITITVS LIMVIAALIT
TLVLKNCCAP SGHTRRNSHQ RKMNQQEESC QNLTDFTPAR VPSSVDIFTA YNETLQCSHE
CVRASVPVYA DETLHSTGEY KSTFNGNRSS SADRHLIPVA FVSEKWFEIS C


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