Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Adipolin (Adipose-derived insulin-sensitizing factor) (C1q and TNF related protein 12) (Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12 (Adipolin fCTRP12) (Adipolin full-length form); Adipolin gC1QTNF12 (Adipolin cleaved form) (Adipolin gCTRP12)]

 ADIPL_HUMAN             Reviewed;         302 AA.
Q5T7M4; Q5EBL5;
17-APR-2007, integrated into UniProtKB/Swiss-Prot.
20-FEB-2007, sequence version 2.
16-JAN-2019, entry version 94.
RecName: Full=Adipolin;
AltName: Full=Adipose-derived insulin-sensitizing factor;
AltName: Full=C1q and TNF related protein 12 {ECO:0000303|PubMed:22275362};
AltName: Full=Complement C1q tumor necrosis factor-related protein 12;
RecName: Full=Adipolin fC1QTNF12;
AltName: Full=Adipolin fCTRP12;
AltName: Full=Adipolin full-length form;
RecName: Full=Adipolin gC1QTNF12;
AltName: Full=Adipolin cleaved form;
AltName: Full=Adipolin gCTRP12;
Flags: Precursor;
Name=C1QTNF12 {ECO:0000312|HGNC:HGNC:32308};
Synonyms=C1QDC2, CTRP12, FAM132A {ECO:0000312|HGNC:HGNC:32308};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=22275362; DOI=10.1074/jbc.M111.303651;
Wei Z., Peterson J.M., Lei X., Cebotaru L., Wolfgang M.J.,
Baldeviano G.C., Wong G.W.;
"C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves
insulin sensitivity and glycemic control in mouse models of obesity
and diabetes.";
J. Biol. Chem. 287:10301-10315(2012).
PubMed=24492466; DOI=10.1530/JOE-13-0537;
Tan B.K., Lewandowski K.C., O'Hare J.P., Randeva H.S.;
"Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex
vivo effects.";
J. Endocrinol. 221:111-119(2014).
-!- FUNCTION: Insulin-sensitizing adipocyte-secreted protein
(adipokine) that regulates glucose metabolism in liver and adipose
tissue. Promotes glucose uptake in adipocytes and suppresses de
novo glucose production in hepatocytes via the PI3K-Akt signaling
pathway. Administration lead to reduction of blood glucose. Able
to attenuate inflammation in fat tissue.
-!- SUBUNIT: Homomultimer; disulfide-linked. May interact with ERFE
(By similarity). {ECO:0000250|UniProtKB:Q8R2Z0}.
-!- SUBCELLULAR LOCATION: Adipolin fC1QTNF12: Secreted
-!- SUBCELLULAR LOCATION: Adipolin gC1QTNF12: Secreted
{ECO:0000269|PubMed:22275362}. Note=In sera is the predominant
form. {ECO:0000269|PubMed:22275362}.
-!- TISSUE SPECIFICITY: Predominantly expressed by adipose tissues.
-!- INDUCTION: By insulin in subcutaneous adipose tissue.
-!- PTM: Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by
FURIN. Insulin enhances endogenous C1QTNF12 cleavage.
-!- SIMILARITY: Belongs to the adipolin/erythroferrone family.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AL162741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC089443; AAH89443.1; -; mRNA.
CCDS; CCDS30554.1; -.
RefSeq; NP_001014980.1; NM_001014980.2.
UniGene; Hs.197613; -.
ProteinModelPortal; Q5T7M4; -.
STRING; 9606.ENSP00000329137; -.
BioMuta; C1QTNF12; -.
DMDM; 145558864; -.
PaxDb; Q5T7M4; -.
PRIDE; Q5T7M4; -.
ProteomicsDB; 64664; -.
Ensembl; ENST00000330388; ENSP00000329137; ENSG00000184163.
GeneID; 388581; -.
KEGG; hsa:388581; -.
UCSC; uc001adl.3; human.
CTD; 388581; -.
DisGeNET; 388581; -.
EuPathDB; HostDB:ENSG00000184163.3; -.
GeneCards; C1QTNF12; -.
HGNC; HGNC:32308; C1QTNF12.
HPA; HPA024107; -.
MIM; 616593; gene.
neXtProt; NX_Q5T7M4; -.
OpenTargets; ENSG00000184163; -.
PharmGKB; PA162386101; -.
eggNOG; ENOG410IF62; Eukaryota.
eggNOG; ENOG4110RD3; LUCA.
GeneTree; ENSGT00940000160300; -.
HOGENOM; HOG000112436; -.
HOVERGEN; HBG107865; -.
InParanoid; Q5T7M4; -.
KO; K21410; -.
OrthoDB; 1462460at2759; -.
PhylomeDB; Q5T7M4; -.
TreeFam; TF331282; -.
GenomeRNAi; 388581; -.
PRO; PR:Q5T7M4; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000184163; Expressed in 111 organ(s), highest expression level in mucosa of transverse colon.
CleanEx; HS_FAM132A; -.
Genevisible; Q5T7M4; HS.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
GO; GO:0045721; P:negative regulation of gluconeogenesis; IBA:GO_Central.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IBA:GO_Central.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0046324; P:regulation of glucose import; ISS:UniProtKB.
GO; GO:0010906; P:regulation of glucose metabolic process; IBA:GO_Central.
Gene3D;; -; 1.
InterPro; IPR001073; C1q_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS50871; C1Q; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Hormone;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 302 Adipolin fC1QTNF12.
CHAIN 98 302 Adipolin gC1QTNF12.
DOMAIN 147 302 C1q. {ECO:0000255|PROSITE-
SITE 97 98 Cleavage; by FURIN.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
VARIANT 14 14 G -> R (in dbSNP:rs7539412).
SEQUENCE 302 AA; 32416 MW; 7A3AA620CD94B31A CRC64;

Related products :

Catalog number Product name Quantity
EIAAB04774 C1QTNF9,C1QTNF9A,Complement C1q tumor necrosis factor-related protein 9,Complement C1q tumor necrosis factor-related protein 9A,Homo sapiens,Human,UNQ6503_PRO21380
EIAAB04775 C1QTNF9B,Complement C1q tumor necrosis factor-related protein 9B,Complement C1q tumor necrosis factor-related protein 9-like,Homo sapiens,Human
25-972 EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signali 0.05 mg
EIAAB04762 C1q_TNF-related protein 8,C1QTNF8,Complement C1q tumor necrosis factor-related protein 8,CTRP8,Homo sapiens,Human,UNQ5829_PRO19648
18-661-15256 C1q and tumor necrosis factor related protein 2 - C1qTNF2; Novel protein; C1q and tumor necrosis factor related protein 2 Polyclonal 0.1 mg
MEDCLA779 Wilm's Tumor Protein 1 (WT1), full length form, WT1 lacking exon 2 form, Clone 6F_H2, Mab anti_Human; paraffin, IH_WB 1 ml.
C304 Complement C1q Tumor Necrosis Factor-Related Protein 1 C1QTNF1 500
EM523 Complement C1q tumor necrosis factor-related protein 3 Elisa Kit 96T
EH1624 Complement C1q tumor necrosis factor-related protein 1 Elisa Kit 96T
pro-653 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 3 2
EM612 Complement C1q tumor necrosis factor-related protein 1 Elisa Kit 96T
pro-135 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 9 10
pro-654 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 1 1mg
pro-655 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 6 1mg
pro-135 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 9 2
pro-134 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 8 2
pro-514 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 7 2
RPR-655 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 6 2
pro-653 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 3 1mg
EH1261 Complement C1q tumor necrosis factor-related protein 3 Elisa Kit 96T
pro-133 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 2 1mg
RPR-134 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 8 2
RPR-135 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 9 2
RPR-653 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 3 2
RPR-133 Recombinant Human Complement C1q Tumor Necrosis Factor-Related Protein 2 2

https://antibody-antibodies.com/ | https://gentaur.com/ | https://gen-script.com/ | https://diagenox.com/ | https://clonagen.com/ | http://gentaursearch.com/ | http://gentaurpub.com/ | https://gentaur-online.com/ | http://anti-anti-pdf.com/ | http://gentaur-worldwide.com/


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur