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Adipolin (Adipose-derived insulin-sensitizing factor) (C1q and TNF related protein 12) (Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12 (Adipolin fCTRP12) (Adipolin full-length form); Adipolin gC1QTNF12 (Adipolin cleaved form) (Adipolin gCTRP12)]

 ADIPL_HUMAN             Reviewed;         302 AA.
Q5T7M4; Q5EBL5;
17-APR-2007, integrated into UniProtKB/Swiss-Prot.
20-FEB-2007, sequence version 2.
12-SEP-2018, entry version 91.
RecName: Full=Adipolin;
AltName: Full=Adipose-derived insulin-sensitizing factor;
AltName: Full=C1q and TNF related protein 12 {ECO:0000303|PubMed:22275362};
AltName: Full=Complement C1q tumor necrosis factor-related protein 12;
Contains:
RecName: Full=Adipolin fC1QTNF12;
AltName: Full=Adipolin fCTRP12;
AltName: Full=Adipolin full-length form;
Contains:
RecName: Full=Adipolin gC1QTNF12;
AltName: Full=Adipolin cleaved form;
AltName: Full=Adipolin gCTRP12;
Flags: Precursor;
Name=C1QTNF12 {ECO:0000312|HGNC:HGNC:32308};
Synonyms=C1QDC2, CTRP12, FAM132A {ECO:0000312|HGNC:HGNC:32308};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed=22275362; DOI=10.1074/jbc.M111.303651;
Wei Z., Peterson J.M., Lei X., Cebotaru L., Wolfgang M.J.,
Baldeviano G.C., Wong G.W.;
"C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves
insulin sensitivity and glycemic control in mouse models of obesity
and diabetes.";
J. Biol. Chem. 287:10301-10315(2012).
[4]
SUBCELLULAR LOCATION, AND INDUCTION.
PubMed=24492466; DOI=10.1530/JOE-13-0537;
Tan B.K., Lewandowski K.C., O'Hare J.P., Randeva H.S.;
"Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex
vivo effects.";
J. Endocrinol. 221:111-119(2014).
-!- FUNCTION: Insulin-sensitizing adipocyte-secreted protein
(adipokine) that regulates glucose metabolism in liver and adipose
tissue. Promotes glucose uptake in adipocytes and suppresses de
novo glucose production in hepatocytes via the PI3K-Akt signaling
pathway. Administration lead to reduction of blood glucose. Able
to attenuate inflammation in fat tissue.
{ECO:0000250|UniProtKB:Q8R2Z0}.
-!- SUBUNIT: Homomultimer; disulfide-linked. May interact with ERFE
(By similarity). {ECO:0000250|UniProtKB:Q8R2Z0}.
-!- SUBCELLULAR LOCATION: Adipolin fC1QTNF12: Secreted
{ECO:0000269|PubMed:22275362}.
-!- SUBCELLULAR LOCATION: Adipolin gC1QTNF12: Secreted
{ECO:0000269|PubMed:22275362}. Note=In sera is the predominant
form. {ECO:0000269|PubMed:22275362}.
-!- TISSUE SPECIFICITY: Predominantly expressed by adipose tissues.
{ECO:0000269|PubMed:22275362}.
-!- INDUCTION: By insulin in subcutaneous adipose tissue.
{ECO:0000269|PubMed:24492466}.
-!- PTM: Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by
FURIN. Insulin enhances endogenous C1QTNF12 cleavage.
{ECO:0000250|UniProtKB:Q8R2Z0}.
-!- SIMILARITY: Belongs to the adipolin/erythroferrone family.
{ECO:0000305}.
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EMBL; AL162741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC089443; AAH89443.1; -; mRNA.
CCDS; CCDS30554.1; -.
RefSeq; NP_001014980.1; NM_001014980.2.
UniGene; Hs.197613; -.
ProteinModelPortal; Q5T7M4; -.
STRING; 9606.ENSP00000329137; -.
BioMuta; FAM132A; -.
DMDM; 145558864; -.
PaxDb; Q5T7M4; -.
PRIDE; Q5T7M4; -.
ProteomicsDB; 64664; -.
Ensembl; ENST00000330388; ENSP00000329137; ENSG00000184163.
GeneID; 388581; -.
KEGG; hsa:388581; -.
UCSC; uc001adl.3; human.
CTD; 388581; -.
DisGeNET; 388581; -.
EuPathDB; HostDB:ENSG00000184163.3; -.
GeneCards; C1QTNF12; -.
HGNC; HGNC:32308; C1QTNF12.
HPA; HPA024107; -.
MIM; 616593; gene.
neXtProt; NX_Q5T7M4; -.
OpenTargets; ENSG00000184163; -.
PharmGKB; PA162386101; -.
eggNOG; ENOG410IF62; Eukaryota.
eggNOG; ENOG4110RD3; LUCA.
GeneTree; ENSGT00390000007846; -.
HOGENOM; HOG000112436; -.
HOVERGEN; HBG107865; -.
InParanoid; Q5T7M4; -.
KO; K21410; -.
OMA; RCRGRDK; -.
OrthoDB; EOG091G0HNK; -.
PhylomeDB; Q5T7M4; -.
TreeFam; TF331282; -.
GenomeRNAi; 388581; -.
PRO; PR:Q5T7M4; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000184163; Expressed in 111 organ(s), highest expression level in mucosa of transverse colon.
CleanEx; HS_FAM132A; -.
Genevisible; Q5T7M4; HS.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0046324; P:regulation of glucose import; ISS:UniProtKB.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR001073; C1q_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS50871; C1Q; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Hormone;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 302 Adipolin fC1QTNF12.
{ECO:0000250|UniProtKB:Q8R2Z0}.
/FTId=PRO_0000284354.
CHAIN 98 302 Adipolin gC1QTNF12.
{ECO:0000250|UniProtKB:Q8R2Z0}.
/FTId=PRO_0000430248.
DOMAIN 147 302 C1q. {ECO:0000255|PROSITE-
ProRule:PRU00368}.
SITE 97 98 Cleavage; by FURIN.
{ECO:0000250|UniProtKB:Q8R2Z0}.
CARBOHYD 43 43 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 14 14 G -> R (in dbSNP:rs7539412).
/FTId=VAR_054065.
SEQUENCE 302 AA; 32416 MW; 7A3AA620CD94B31A CRC64;
MRRWAWAAVV VLLGPQLVLL GGVGARREAQ RTQQPGQRAD PPNATASASS REGLPEAPKP
SQASGPEFSD AHMTWLNFVR RPDDGALRKR CGSRDKKPRD LFGPPGPPGA EVTAETLLHE
FQELLKEATE RRFSGLLDPL LPQGAGLRLV GEAFHCRLQG PRRVDKRTLV ELHGFQAPAA
QGAFLRGSGL SLASGRFTAP VSGIFQFSAS LHVDHSELQG KARLRARDVV CVLICIESLC
QRHTCLEAVS GLESNSRVFT LQVQGLLQLQ AGQYASVFVD NGSGAVLTIQ AGSSFSGLLL
GT


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