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Agouti related protein homolog (Mouse) (Agouti-related protein)

 C6SUN5_HUMAN            Unreviewed;       132 AA.
C6SUN5;
22-SEP-2009, integrated into UniProtKB/TrEMBL.
22-SEP-2009, sequence version 1.
12-SEP-2018, entry version 83.
SubName: Full=Agouti related protein homolog (Mouse) {ECO:0000313|EMBL:EAW83137.1};
SubName: Full=Agouti-related protein {ECO:0000313|EMBL:DAA06531.1};
Name=AgRP {ECO:0000313|EMBL:DAA06531.1};
Synonyms=AGRP {ECO:0000313|EMBL:EAW83137.1};
ORFNames=hCG_28814 {ECO:0000313|EMBL:EAW83137.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:DAA06531.1};
[1] {ECO:0000313|EMBL:DAA06531.1}
NUCLEOTIDE SEQUENCE.
PubMed=11602360; DOI=10.1016/S0378-1119(01)00705-3;
Brown A.M., Mayfield D.K., Volaufova J., Argyropoulos G.;
"The gene structure and minimal promoter of the human agouti related
protein.";
Gene 277:231-238(2001).
[2] {ECO:0000313|EMBL:EAW83137.1}
NUCLEOTIDE SEQUENCE.
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[3] {ECO:0000313|EMBL:EAW83137.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:DAA06531.1}
NUCLEOTIDE SEQUENCE.
PubMed=19285986; DOI=10.1016/j.jmb.2009.03.017;
Ilnytska O., Sozen M.A., Dauterive R., Argyropoulos G.;
"Control elements in the neighboring ATPase gene influence
spatiotemporal expression of the human agouti-related protein.";
J. Mol. Biol. 388:239-251(2009).
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00494}.
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EMBL; BK006637; DAA06531.1; -; Genomic_DNA.
EMBL; CH471092; EAW83137.1; -; Genomic_DNA.
RefSeq; NP_001129.1; NM_001138.1.
UniGene; Hs.104633; -.
SMR; C6SUN5; -.
PRIDE; C6SUN5; -.
GeneID; 181; -.
KEGG; hsa:181; -.
CTD; 181; -.
EuPathDB; HostDB:ENSG00000159723.4; -.
PharmGKB; PA24627; -.
eggNOG; ENOG410J14P; Eukaryota.
eggNOG; ENOG410Z66T; LUCA.
KO; K05231; -.
OMA; GHQVPCC; -.
OrthoDB; EOG091G1506; -.
GenomeRNAi; 181; -.
Bgee; ENSG00000159723; Expressed in 66 organ(s), highest expression level in left adrenal gland.
ExpressionAtlas; C6SUN5; baseline and differential.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl.
GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0042755; P:eating behavior; IEA:Ensembl.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0048571; P:long-day photoperiodism; IEA:Ensembl.
GO; GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
GO; GO:2000253; P:positive regulation of feeding behavior; IEA:Ensembl.
GO; GO:0032868; P:response to insulin; IEA:Ensembl.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00494};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 132 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014302140.
DOMAIN 87 129 Agouti. {ECO:0000259|PROSITE:PS51150}.
COILED 56 76 {ECO:0000256|SAM:Coils}.
DISULFID 87 102 {ECO:0000256|PROSITE-ProRule:PRU00494}.
DISULFID 94 108 {ECO:0000256|PROSITE-ProRule:PRU00494}.
DISULFID 101 119 {ECO:0000256|PROSITE-ProRule:PRU00494}.
DISULFID 110 117 {ECO:0000256|PROSITE-ProRule:PRU00494}.
SEQUENCE 132 AA; 14440 MW; 1CCBE112C3EB10F5 CRC64;
MLTAAVLSCA LLLALPATRG AQMGLAPMEG IRRPDQALLP ELPGLGLRAP LKKTTAEQAE
EDLLQEAQAL AEVLDLQDRE PRSSRRCVRL HESCLGQQVP CCDPCATCYC RFFNAFCYCR
KLGTAMNPCS RT


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