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Agouti-related protein

 AGRP_MOUSE              Reviewed;         131 AA.
P56473; O35967;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 1.
12-SEP-2018, entry version 133.
RecName: Full=Agouti-related protein;
Flags: Precursor;
Name=Agrp; Synonyms=Agrt, Art;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE.
STRAIN=129;
PubMed=9311920; DOI=10.1126/science.278.5335.135;
Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I.,
Barsh G.S.;
"Antagonism of central melanocortin receptors in vitro and in vivo by
agouti-related protein.";
Science 278:135-138(1997).
[2]
NUCLEOTIDE SEQUENCE.
PubMed=9119224; DOI=10.1101/gad.11.5.593;
Shutter J.R., Graham M., Kinsey A.C., Scully S., Luethy R.,
Stark K.L.;
"Hypothalamic expression of ART, a novel gene related to agouti, is
up-regulated in obese and diabetic mutant mice.";
Genes Dev. 11:593-602(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND INTERACTION WITH MELANOCORTIN RECEPTORS MC3R; MC4R AND
MC5R.
PubMed=9892020; DOI=10.1210/mend.13.1.0223;
Yang Y.K., Thompson D.A., Dickinson C.J., Wilken J., Barsh G.S.,
Kent S.B., Gantz I.;
"Characterization of Agouti-related protein binding to melanocortin
receptors.";
Mol. Endocrinol. 13:148-155(1999).
-!- FUNCTION: Plays a role in weight homeostasis. Involved in the
control of feeding behavior through the central melanocortin
system. Acts as alpha melanocyte-stimulating hormone antagonist by
inhibiting cAMP production mediated by stimulation of melanocortin
receptors within the hypothalamus and adrenal gland. Has very low
activity with MC5R. Is an inverse agonist for MC3R and MC4R being
able to suppress their constitutive activity (By similarity). It
promotes MC3R and MC4R endocytosis in an arrestin-dependent manner
(By similarity). {ECO:0000250, ECO:0000269|PubMed:9892020}.
-!- SUBUNIT: Interacts with melanocortin receptors MC3R, MC4R and
MC5R. {ECO:0000269|PubMed:9892020}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00253}.
Golgi apparatus lumen {ECO:0000250|UniProtKB:O00253}.
-!- TISSUE SPECIFICITY: Expressed in arcuate nucleus and median
eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
-!- INDUCTION: Hypothalamic expression is elevated circa 10-fold in
ob/ob and db/db mice.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin.
{ECO:0000250|UniProtKB:O00253}.
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EMBL; U89484; AAB68620.1; -; mRNA.
EMBL; U89486; AAB68622.1; -; Genomic_DNA.
EMBL; BC079902; AAH79902.1; -; mRNA.
CCDS; CCDS22605.1; -.
RefSeq; NP_001258735.1; NM_001271806.1.
RefSeq; NP_031453.1; NM_007427.3.
UniGene; Mm.441696; -.
UniGene; Mm.491630; -.
ProteinModelPortal; P56473; -.
SMR; P56473; -.
STRING; 10090.ENSMUSP00000005849; -.
PaxDb; P56473; -.
PRIDE; P56473; -.
Ensembl; ENSMUST00000005849; ENSMUSP00000005849; ENSMUSG00000005705.
Ensembl; ENSMUST00000194091; ENSMUSP00000142044; ENSMUSG00000005705.
GeneID; 11604; -.
KEGG; mmu:11604; -.
UCSC; uc009ndh.2; mouse.
CTD; 181; -.
MGI; MGI:892013; Agrp.
eggNOG; ENOG410J14P; Eukaryota.
eggNOG; ENOG410Z66T; LUCA.
GeneTree; ENSGT00510000048590; -.
HOGENOM; HOG000033861; -.
HOVERGEN; HBG050467; -.
InParanoid; P56473; -.
KO; K05231; -.
OMA; GHQVPCC; -.
OrthoDB; EOG091G1506; -.
PhylomeDB; P56473; -.
TreeFam; TF330729; -.
PRO; PR:P56473; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000005705; Expressed in 58 organ(s), highest expression level in median eminence of neurohypophysis.
CleanEx; MM_AGRP; -.
ExpressionAtlas; P56473; baseline and differential.
Genevisible; P56473; MM.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
GO; GO:0043025; C:neuronal cell body; ISO:MGI.
GO; GO:0005184; F:neuropeptide hormone activity; IDA:MGI.
GO; GO:0031781; F:type 3 melanocortin receptor binding; ISS:UniProtKB.
GO; GO:0031782; F:type 4 melanocortin receptor binding; ISS:UniProtKB.
GO; GO:0008343; P:adult feeding behavior; IDA:MGI.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0042755; P:eating behavior; ISO:MGI.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0048571; P:long-day photoperiodism; IEA:Ensembl.
GO; GO:0060135; P:maternal process involved in female pregnancy; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
GO; GO:2000253; P:positive regulation of feeding behavior; ISO:MGI.
GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
GO; GO:0032868; P:response to insulin; IEA:Ensembl.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Golgi apparatus; Knottin;
Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 81 {ECO:0000250|UniProtKB:O00253}.
/FTId=PRO_0000434045.
CHAIN 82 131 Agouti-related protein.
/FTId=PRO_0000001035.
DOMAIN 86 128 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
REGION 110 112 Interaction with melanocortin receptors.
{ECO:0000250}.
SITE 81 82 Cleavage; by PCSK1.
{ECO:0000250|UniProtKB:O00253}.
DISULFID 86 101 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 93 107 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 100 118 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 104 128 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 109 116 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
SEQUENCE 131 AA; 14432 MW; 25D9766D074C6834 CRC64;
MLTAMLLSCV LLLALPPTLG VQMGVAPLKG IRRPDQALFP EFPGLSLNGL KKTTADRAEE
VLLQKAEALA EVLDPQNRES RSPRRCVRLH ESCLGQQVPC CDPCATCYCR FFNAFCYCRK
LGTATNLCSR T


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