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Agouti-related protein

 AGRP_PIG                Reviewed;         134 AA.
Q9TU18;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 2.
23-MAY-2018, entry version 88.
RecName: Full=Agouti-related protein;
Flags: Precursor;
Name=AGRP;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=12019634; DOI=10.2527/2002.8051388x;
Halverson M.J., Donelan K.J., Granholm N.H., Cheesbrough T.M.,
Westby C.A., Marshall D.M.;
"Sequencing of the porcine agouti-related protein (AGRP) gene.";
J. Anim. Sci. 80:1388-1389(2002).
-!- FUNCTION: Plays a role in weight homeostasis. Involved in the
control of feeding behavior through the central melanocortin
system. Acts as alpha melanocyte-stimulating hormone antagonist by
inhibiting cAMP production mediated by stimulation of melanocortin
receptors within the hypothalamus and adrenal gland. Has very low
activity with MC5R. Is an inverse agonist for MC3R and MC4R being
able to suppress their constitutive activity. It promotes MC3R and
MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250}.
-!- SUBUNIT: Interacts with melanocortin receptors MC3R, MC4R and
MC5R. {ECO:0000250|UniProtKB:O00253}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00253}.
Golgi apparatus lumen {ECO:0000250|UniProtKB:O00253}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin.
{ECO:0000250|UniProtKB:O00253}.
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EMBL; AF177762; AAF13865.2; -; Genomic_DNA.
RefSeq; NP_001011693.1; NM_001011693.1.
RefSeq; XP_013853683.1; XM_013998229.1.
RefSeq; XP_013853684.1; XM_013998230.1.
UniGene; Ssc.483; -.
ProteinModelPortal; Q9TU18; -.
SMR; Q9TU18; -.
STRING; 9823.ENSSSCP00000002994; -.
PaxDb; Q9TU18; -.
PRIDE; Q9TU18; -.
Ensembl; ENSSSCT00000003073; ENSSSCP00000002994; ENSSSCG00000002775.
GeneID; 397275; -.
KEGG; ssc:397275; -.
CTD; 181; -.
eggNOG; ENOG410J14P; Eukaryota.
eggNOG; ENOG410Z66T; LUCA.
GeneTree; ENSGT00510000048590; -.
HOGENOM; HOG000033861; -.
HOVERGEN; HBG050467; -.
InParanoid; Q9TU18; -.
KO; K05231; -.
OMA; GHQVPCC; -.
OrthoDB; EOG091G1506; -.
TreeFam; TF330729; -.
Proteomes; UP000008227; Chromosome 6.
Genevisible; Q9TU18; SS.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
GO; GO:0031781; F:type 3 melanocortin receptor binding; ISS:UniProtKB.
GO; GO:0031782; F:type 4 melanocortin receptor binding; ISS:UniProtKB.
GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
3: Inferred from homology;
Complete proteome; Disulfide bond; Golgi apparatus; Knottin;
Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 84 {ECO:0000250|UniProtKB:O00253}.
/FTId=PRO_0000434046.
CHAIN 85 134 Agouti-related protein.
/FTId=PRO_0000001036.
DOMAIN 89 131 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
REGION 113 115 Interaction with melanocortin receptors.
{ECO:0000250}.
SITE 84 85 Cleavage; by PCSK1.
{ECO:0000250|UniProtKB:O00253}.
DISULFID 89 104 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 96 110 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 103 121 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 107 131 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 112 119 {ECO:0000250|UniProtKB:O00253,
ECO:0000255|PROSITE-ProRule:PRU00494}.
SEQUENCE 134 AA; 14681 MW; DA89AC087567889A CRC64;
MLTTMLLSCA LLLAMPTMLG AQIGLAPLEG IGRLDQALFP ELQDLGLQPP LKRTTAERAE
EALLQQAEAK ALAEVLDPEG RKARSPRRCV RLHESCLGHQ VPCCDPCATC YCRFFNAFCY
CRKLGTATNP CSRT


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