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Agouti-signaling protein (ASP) (Agouti coat color protein) (Agouti switch protein)

 ASIP_MOUSE              Reviewed;         131 AA.
Q03288; A2ALT3; Q80ST0;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
28-JUN-2011, sequence version 2.
25-OCT-2017, entry version 137.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti coat color protein;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=Asip; Synonyms=a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8449404; DOI=10.1101/gad.7.3.454;
Miller M.W., Duhl D.M., Vrieling H., Cordes S.P., Ollmann M.M.,
Winkes B.M., Barsh G.S.;
"Cloning of the mouse agouti gene predicts a secreted protein
ubiquitously expressed in mice carrying the lethal yellow mutation.";
Genes Dev. 7:454-467(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1473152; DOI=10.1016/S0092-8674(05)80067-4;
Bultman S.J., Michaud E.J., Woychik R.P.;
"Molecular characterization of the mouse agouti locus.";
Cell 71:1195-1204(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-70.
PubMed=8319910; DOI=10.1101/gad.7.7a.1203;
Michaud E.J., Bultman S.J., Stubbs L.J., Woychik R.P.;
"The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is
associated with the disruption of a novel RNA-binding protein.";
Genes Dev. 7:1203-1213(1993).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-16.
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=7987393; DOI=10.1038/ng0994-59;
Duhl D.M., Vrieling H., Miller K.A., Wolff G.L., Barsh G.S.;
"Neomorphic agouti mutations in obese yellow mice.";
Nat. Genet. 8:59-65(1994).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-16.
PubMed=8202545; DOI=10.1073/pnas.91.12.5667;
Vrieling H., Duhl D.M., Millar S.E., Miller K.A., Barsh G.S.;
"Differences in dorsal and ventral pigmentation result from regional
expression of the mouse agouti gene.";
Proc. Natl. Acad. Sci. U.S.A. 91:5667-5671(1994).
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment). Causes hair
follicle melanocytes to synthesize phaeomelanin instead of black
or brown pigment eumelanin and produces hairs with a subapical
yellow band on an otherwise black or brown background when
expressed during the mid-portion of hair growth.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Epithelial cells of the hair follicles and the
epidermis.
-!- DEVELOPMENTAL STAGE: Widely expressed in embryonic and neonatal
skin.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; L06451; AAA37201.1; -; mRNA.
EMBL; L06941; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AL805955; CAM17068.1; -; Genomic_DNA.
EMBL; CH466551; EDL06105.1; -; Genomic_DNA.
EMBL; CH466551; EDL06106.1; -; Genomic_DNA.
EMBL; BC009122; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; S63413; AAA15908.1; -; mRNA.
EMBL; S70320; AAP19635.1; -; mRNA.
EMBL; S70326; AAP19636.1; -; mRNA.
EMBL; S70394; AAP19637.1; -; mRNA.
EMBL; S74479; AAP31517.1; -; mRNA.
EMBL; S74489; AAP31519.1; -; mRNA.
EMBL; S74493; AAP31520.1; -; mRNA.
CCDS; CCDS16941.1; -.
PIR; A46298; A46298.
RefSeq; NP_056585.2; NM_015770.3.
UniGene; Mm.315593; -.
UniGene; Mm.488809; -.
ProteinModelPortal; Q03288; -.
SMR; Q03288; -.
STRING; 10090.ENSMUSP00000029123; -.
iPTMnet; Q03288; -.
PhosphoSitePlus; Q03288; -.
PaxDb; Q03288; -.
PRIDE; Q03288; -.
Ensembl; ENSMUST00000029123; ENSMUSP00000029123; ENSMUSG00000027596.
Ensembl; ENSMUST00000109697; ENSMUSP00000105319; ENSMUSG00000027596.
GeneID; 50518; -.
KEGG; mmu:50518; -.
UCSC; uc008njz.1; mouse.
CTD; 50518; -.
MGI; MGI:87853; a.
eggNOG; ENOG410J1GH; Eukaryota.
eggNOG; ENOG410ZCK9; LUCA.
GeneTree; ENSGT00510000048661; -.
HOGENOM; HOG000111779; -.
HOVERGEN; HBG050593; -.
InParanoid; Q03288; -.
KO; K08725; -.
OMA; CSCRVLN; -.
OrthoDB; EOG091G0ZG5; -.
TreeFam; TF330729; -.
PRO; PR:Q03288; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027596; -.
CleanEx; MM_A; -.
ExpressionAtlas; Q03288; baseline and differential.
Genevisible; Q03288; MM.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0031779; F:melanocortin receptor binding; IPI:MGI.
GO; GO:0031781; F:type 3 melanocortin receptor binding; IPI:MGI.
GO; GO:0031782; F:type 4 melanocortin receptor binding; IPI:MGI.
GO; GO:0008343; P:adult feeding behavior; IMP:MGI.
GO; GO:0006091; P:generation of precursor metabolites and energy; IGI:MGI.
GO; GO:0071514; P:genetic imprinting; IMP:MGI.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0042438; P:melanin biosynthetic process; IMP:MGI.
GO; GO:0032438; P:melanosome organization; IMP:MGI.
GO; GO:0032402; P:melanosome transport; IMP:MGI.
GO; GO:0043473; P:pigmentation; IMP:MGI.
GO; GO:0048023; P:positive regulation of melanin biosynthetic process; IGI:CACAO.
GO; GO:0040030; P:regulation of molecular function, epigenetic; IMP:MGI.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Knottin;
Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 131 Agouti-signaling protein.
/FTId=PRO_0000001029.
DOMAIN 92 131 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 57 85 Arg/Lys-rich (basic).
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 92 107 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 99 113 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 106 124 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 110 131 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 115 122 {ECO:0000255|PROSITE-ProRule:PRU00494}.
CONFLICT 13 13 G -> S (in Ref. 1; AAA37201 and 6;
AAA15908/AAP19635/AAP19636/AAP19637/
AAP31517/AAP31519/AAP31520).
{ECO:0000305}.
SEQUENCE 131 AA; 14313 MW; A7544EEA26734135 CRC64;
MDVTRLLLAT LVGFLCFFTV HSHLALEETL GDDRSLRSNS SMNSLDFSSV SIVALNKKSK
KISRKEAEKR KRSSKKKASM KKVARPPPPS PCVATRDSCK PPAPACCDPC ASCQCRFFGS
ACTCRVLNPN C


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