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Agouti-signaling protein (ASP) (Agouti switch protein)

 ASIP_PONPY              Reviewed;         132 AA.
Q1XGV4; A1YL65;
16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
02-MAY-2006, sequence version 1.
23-MAY-2018, entry version 47.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=ASIP;
Pongo pygmaeus (Bornean orangutan).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9600;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=16597585; DOI=10.1101/gr.4763906;
Nakayama K., Ishida T.;
"Alu-mediated 100-kb deletion in the primate genome: the loss of the
agouti signaling protein gene in the lesser apes.";
Genome Res. 16:485-490(2006).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=17143587; DOI=10.1007/s00335-006-0056-0;
Mundy N.I., Kelly J.;
"Investigation of the role of the agouti signaling protein gene (ASIP)
in coat color evolution in primates.";
Mamm. Genome 17:1205-1213(2006).
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment) (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
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EMBL; AB236872; BAE93020.1; -; Genomic_DNA.
EMBL; EF094482; ABL84280.1; -; Genomic_DNA.
SMR; Q1XGV4; -.
HOGENOM; HOG000111779; -.
HOVERGEN; HBG050593; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
3: Inferred from homology;
Disulfide bond; Glycoprotein; Knottin; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 132 Agouti-signaling protein.
/FTId=PRO_0000235192.
DOMAIN 93 132 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 57 86 Arg/Lys-rich (basic).
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 93 108 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 100 114 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 107 125 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 111 132 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 116 123 {ECO:0000255|PROSITE-ProRule:PRU00494}.
SEQUENCE 132 AA; 14597 MW; 99087926CB92E0E9 CRC64;
MDVTRLLLAT LLVFLCFFTA DSHLPPEEKL RDDRSLRSNS SVNLLDFPSV SIVALNKKSK
QISRKEAEKK RSSKKEASMK TVARPRTPLS APCVATRNSC KPPAPACCDP CASCQCRFFR
SACSCRVLSL NC


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