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Agouti-signaling protein (ASP) (Agouti switch protein)

 ASIP_BOVIN              Reviewed;         133 AA.
Q29414; Q3T0R3; Q53Z62;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 2.
12-SEP-2018, entry version 112.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=ASIP;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Kidney;
PubMed=15649150; DOI=10.1111/j.1600-0749.2004.00195.x;
Girardot M., Martin J., Guibert S., Leveziel H., Julien R.,
Oulmouden A.;
"Widespread expression of the bovine Agouti gene results from at least
three alternative promoters.";
Pigment Cell Res. 18:34-41(2005).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Royo L.J., Alvarez I., Fernandez I., Arranz J.J., Gomez E.,
Goyache F.;
"Agouti variation within wild-type coat color in cattle is not
dependent on changes in the coding sequence of the ASIP gene.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment) (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
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EMBL; X99692; CAA68004.1; -; mRNA.
EMBL; X99691; CAA68003.1; -; Genomic_DNA.
EMBL; AY352659; AAQ56605.2; -; Genomic_DNA.
EMBL; AY348953; AAQ56605.2; JOINED; Genomic_DNA.
EMBL; AY348954; AAQ56605.2; JOINED; Genomic_DNA.
EMBL; BC102291; AAI02292.1; -; mRNA.
RefSeq; NP_996674.1; NM_206843.2.
UniGene; Bt.89130; -.
ProteinModelPortal; Q29414; -.
SMR; Q29414; -.
STRING; 9913.ENSBTAP00000045382; -.
PaxDb; Q29414; -.
PRIDE; Q29414; -.
Ensembl; ENSBTAT00000048322; ENSBTAP00000045382; ENSBTAG00000034077.
GeneID; 404192; -.
KEGG; bta:404192; -.
CTD; 434; -.
VGNC; VGNC:26214; ASIP.
eggNOG; ENOG410J1GH; Eukaryota.
eggNOG; ENOG410ZCK9; LUCA.
GeneTree; ENSGT00510000048661; -.
HOGENOM; HOG000111779; -.
HOVERGEN; HBG050593; -.
InParanoid; Q29414; -.
KO; K08725; -.
OMA; CSCRVLN; -.
OrthoDB; EOG091G0ZG5; -.
TreeFam; TF330729; -.
Proteomes; UP000009136; Chromosome 13.
Bgee; ENSBTAG00000034077; Expressed in 9 organ(s), highest expression level in prefrontal cortex.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0031781; F:type 3 melanocortin receptor binding; IEA:Ensembl.
GO; GO:0031782; F:type 4 melanocortin receptor binding; IEA:Ensembl.
GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
GO; GO:0006091; P:generation of precursor metabolites and energy; IEA:Ensembl.
GO; GO:0071514; P:genetic imprinting; IEA:Ensembl.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
GO; GO:0032438; P:melanosome organization; IEA:Ensembl.
GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
GO; GO:0048023; P:positive regulation of melanin biosynthetic process; IEA:Ensembl.
GO; GO:0040030; P:regulation of molecular function, epigenetic; IEA:Ensembl.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Knottin;
Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 133 Agouti-signaling protein.
/FTId=PRO_0000001024.
DOMAIN 94 133 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 57 86 Arg/Lys-rich (basic).
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 94 109 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 101 115 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 108 126 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 112 133 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 117 124 {ECO:0000255|PROSITE-ProRule:PRU00494}.
SEQUENCE 133 AA; 14841 MW; 241759680412CE07 CRC64;
MDVSRLLLAT LLVCLCFLTA YSHLAPEEKP RDERNLKNNS SMNLLDFPSV SIVALNKKSK
KISRNEAEKK KRPSKRKAPM KNVARTRPPP PTPCVATRDS CKPPAPACCD PCAFCQCRFF
RSACSCRVLN PTC


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