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Agouti-signaling protein (ASP) (Agouti switch protein)

 ASIP_CANLF              Reviewed;         131 AA.
Q5UK76;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
07-DEC-2004, sequence version 1.
23-MAY-2018, entry version 60.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=ASIP;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-96.
PubMed=15520882; DOI=10.1007/s00335-004-2377-1;
Kerns J.A., Newton J., Berryere T.G., Rubin E.M., Cheng J.F.,
Schmutz S.M., Barsh G.S.;
"Characterization of the dog Agouti gene and a nonagoutimutation in
German Shepherd dogs.";
Mamm. Genome 15:798-808(2004).
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
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EMBL; AY714374; AAV48541.1; -; mRNA.
RefSeq; NP_001007264.1; NM_001007263.1.
UniGene; Cfa.16237; -.
ProteinModelPortal; Q5UK76; -.
SMR; Q5UK76; -.
STRING; 9615.ENSCAFP00000034367; -.
PaxDb; Q5UK76; -.
PRIDE; Q5UK76; -.
GeneID; 492296; -.
KEGG; cfa:492296; -.
CTD; 434; -.
eggNOG; ENOG410J1GH; Eukaryota.
eggNOG; ENOG410ZCK9; LUCA.
HOVERGEN; HBG050593; -.
InParanoid; Q5UK76; -.
KO; K08725; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Knottin;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 131 Agouti-signaling protein.
/FTId=PRO_0000001025.
DOMAIN 92 131 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 56 84 Arg/Lys-rich (basic).
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 92 107 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 99 113 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 106 124 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 110 131 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 115 122 {ECO:0000255|PROSITE-ProRule:PRU00494}.
VARIANT 96 96 R -> C (in strain: Black German
Shepherd). {ECO:0000269|PubMed:15520882}.
SEQUENCE 131 AA; 14505 MW; 4204DDB437B49954 CRC64;
MNIFRLLLAT LLVSLCFLTA YSHLAEEKPK DDRSLRSNSS VNLLDFPSVS IVALNKKSKK
ISRKEAEKKR SSKKKASMKN VARPRPPPPT PCVATRNSCK SPAPACCDPC ASCQCRFFRS
ACTCRVLSPR C


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