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Agouti-signaling protein (ASP) (Agouti switch protein)

 ASIP_PIG                Reviewed;         131 AA.
Q6ZYM3; Q4R1H8; Q5QJU6;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
05-DEC-2018, entry version 90.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=ASIP;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11105218; DOI=10.1046/j.1365-2052.2000.00656.x;
Leeb T., Deppe A., Kriegesmann B., Brenig B.;
"Genomic structure and nucleotide polymorphisms of the porcine agouti
signalling protein gene (ASIP).";
Anim. Genet. 31:335-336(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=16416091; DOI=10.1007/s00335-005-0104-1;
Droegemueller C., Giese A., Martins-Wess F., Wiedemann S.,
Andersson L., Brenig B., Fries R., Leeb T.;
"The mutation causing the black-and-tan pigmentation phenotype of
Mangalitza pigs maps to the porcine ASIP locus but does not affect its
coding sequence.";
Mamm. Genome 17:58-66(2006).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT LYS-68.
Shi K., Deng X., Wang A., Li N.;
"Single nucleotide polymorphism analysis on the exons of porcine
Agouti signaling protein.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Shi K., Wang A., Li N.;
"Single nucleotide polymorphisms (SNPs) analysis on the extension
(MC1R), the white (KIT) and the agouti (ASIP) loci and their
association with coat color phenotypes of pigs.";
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Okumura N., Nii M., Hamasima N.;
"Expression of agouti signaling protein gene (ASIP) in pig.";
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment) (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
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EMBL; AJ634673; CAG25494.1; -; mRNA.
EMBL; AJ634674; CAG25495.1; -; mRNA.
EMBL; AJ634675; CAG25496.1; -; mRNA.
EMBL; AJ634676; CAG25497.1; -; mRNA.
EMBL; AJ634677; CAG25498.1; -; mRNA.
EMBL; AJ427478; CAD20602.1; -; Genomic_DNA.
EMBL; AY308996; AAQ84057.1; -; mRNA.
EMBL; AY308997; AAQ84058.1; -; mRNA.
EMBL; AY308998; AAQ84059.1; -; mRNA.
EMBL; AY916525; AAX18261.1; -; Genomic_DNA.
EMBL; AB206998; BAD99575.1; -; Genomic_DNA.
RefSeq; NP_001001648.1; NM_001001648.4.
RefSeq; NP_001011646.1; NM_001011646.1.
RefSeq; NP_001011647.1; NM_001011647.1.
RefSeq; NP_001011648.1; NM_001011648.1.
RefSeq; XP_005672916.1; XM_005672859.2.
RefSeq; XP_005672917.1; XM_005672860.2.
RefSeq; XP_013840735.1; XM_013985281.1.
RefSeq; XP_013840736.1; XM_013985282.1.
UniGene; Ssc.42704; -.
SMR; Q6ZYM3; -.
STRING; 9823.ENSSSCP00000007749; -.
PaxDb; Q6ZYM3; -.
PRIDE; Q6ZYM3; -.
Ensembl; ENSSSCT00000007962; ENSSSCP00000007749; ENSSSCG00000007277.
Ensembl; ENSSSCT00000037943; ENSSSCP00000045187; ENSSSCG00000007277.
Ensembl; ENSSSCT00000040677; ENSSSCP00000031257; ENSSSCG00000007277.
GeneID; 414439; -.
KEGG; ssc:414439; -.
CTD; 434; -.
eggNOG; ENOG410J1GH; Eukaryota.
eggNOG; ENOG410ZCK9; LUCA.
GeneTree; ENSGT00940000154258; -.
HOGENOM; HOG000111779; -.
HOVERGEN; HBG050593; -.
InParanoid; Q6ZYM3; -.
KO; K08725; -.
OrthoDB; EOG091G0ZG5; -.
TreeFam; TF330729; -.
ChiTaRS; ASIP; pig.
Proteomes; UP000008227; Chromosome 17.
ExpressionAtlas; Q6ZYM3; baseline and differential.
Genevisible; Q6ZYM3; SS.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0031781; F:type 3 melanocortin receptor binding; IEA:Ensembl.
GO; GO:0031782; F:type 4 melanocortin receptor binding; IEA:Ensembl.
GO; GO:0008343; P:adult feeding behavior; IEA:Ensembl.
GO; GO:0006091; P:generation of precursor metabolites and energy; IEA:Ensembl.
GO; GO:0071514; P:genetic imprinting; IEA:Ensembl.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
GO; GO:0032438; P:melanosome organization; IEA:Ensembl.
GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
GO; GO:0048023; P:positive regulation of melanin biosynthetic process; IEA:Ensembl.
GO; GO:0040030; P:regulation of molecular function, epigenetic; IEA:Ensembl.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Knottin;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 131 Agouti-signaling protein.
/FTId=PRO_0000001030.
DOMAIN 92 131 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 57 84 Arg/Lys-rich (basic).
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 92 107 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 99 113 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 106 124 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 110 131 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 115 122 {ECO:0000255|PROSITE-ProRule:PRU00494}.
VARIANT 68 68 E -> K. {ECO:0000269|Ref.3}.
SEQUENCE 131 AA; 14498 MW; 05BBBAB9E765B68D CRC64;
MDVTRLLLAT LLVCLCFFTA SSHLAPEEKS KDERSLRSNS SMNLLDFPSV SIVALNKKSK
KISRKEAEKR SSKKKASMKK VAQPRPPRPA PCVANRDSCK PPALACCDPC AFCQCRFFRS
ACSCRVLNPT C


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