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Agouti-signaling protein (ASP) (Agouti switch protein)

 ASIP_FELCA              Reviewed;         135 AA.
Q865F0;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-NOV-2018, entry version 88.
RecName: Full=Agouti-signaling protein;
Short=ASP;
AltName: Full=Agouti switch protein;
Flags: Precursor;
Name=ASIP;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Isolate Fca273;
PubMed=12620197; DOI=10.1016/S0960-9822(03)00128-3;
Eizirik E., Yuhki N., Johnson W.E., Menotti-Raymond M., Hannah S.S.,
O'Brien S.J.;
"Molecular genetics and evolution of melanism in the cat family.";
Curr. Biol. 13:448-453(2003).
-!- FUNCTION: Involved in the regulation of melanogenesis. The binding
of ASP to MC1R precludes alpha-MSH initiated signaling and thus
blocks production of cAMP, leading to a down-regulation of
eumelanogenesis (brown/black pigment) and thus increasing
synthesis of pheomelanin (yellow/red pigment) (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
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EMBL; AY237394; AAO62411.1; -; Genomic_DNA.
RefSeq; NP_001009190.1; NM_001009190.1.
RefSeq; XP_006929845.1; XM_006929783.2.
RefSeq; XP_019681722.1; XM_019826163.1.
RefSeq; XP_019681723.1; XM_019826164.1.
RefSeq; XP_019681724.1; XM_019826165.1.
RefSeq; XP_019681725.1; XM_019826166.1.
RefSeq; XP_019681726.1; XM_019826167.1.
RefSeq; XP_019681727.1; XM_019826168.1.
RefSeq; XP_019681728.1; XM_019826169.1.
SMR; Q865F0; -.
PRIDE; Q865F0; -.
GeneID; 492297; -.
KEGG; fca:492297; -.
CTD; 434; -.
HOGENOM; HOG000111779; -.
HOVERGEN; HBG050593; -.
InParanoid; Q865F0; -.
KO; K08725; -.
OMA; AFCQCRL; -.
TreeFam; TF330729; -.
Proteomes; UP000011712; Unplaced.
Bgee; ENSFCAG00000011037; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
Gene3D; 4.10.760.10; -; 1.
InterPro; IPR007733; Agouti.
InterPro; IPR027300; Agouti_dom.
InterPro; IPR036836; Agouti_dom_sf.
PANTHER; PTHR16551; PTHR16551; 1.
Pfam; PF05039; Agouti; 1.
SMART; SM00792; Agouti; 1.
SUPFAM; SSF57055; SSF57055; 1.
PROSITE; PS60024; AGOUTI_1; 1.
PROSITE; PS51150; AGOUTI_2; 1.
3: Inferred from homology;
Complete proteome; Disulfide bond; Glycoprotein; Knottin;
Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
CHAIN 23 135 Agouti-signaling protein.
/FTId=PRO_0000001026.
DOMAIN 96 135 Agouti. {ECO:0000255|PROSITE-
ProRule:PRU00494}.
COMPBIAS 57 88 Arg/Lys-rich (basic).
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 96 111 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 103 117 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 110 128 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 114 135 {ECO:0000255|PROSITE-ProRule:PRU00494}.
DISULFID 119 126 {ECO:0000255|PROSITE-ProRule:PRU00494}.
SEQUENCE 135 AA; 14948 MW; FF748AE9C862E489 CRC64;
MNILRLLLAT LLVCLCLLTA YSHLAPEEKP RDDRNLRSNS SMNMLDLSSV SIVALNKKSK
KISRKEAEKK RSSKKKASMK NVAQPRRPRP PPPAPCVATR DSCKPPAPAC CDPCASCQCR
FFRSSCSCRV LNPTC


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