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Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) (Fragment)

 ALAT1_PIG               Reviewed;          20 AA.
P13191;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
05-DEC-2018, entry version 96.
RecName: Full=Alanine aminotransferase 1;
Short=ALT1;
EC=2.6.1.2;
AltName: Full=Glutamate pyruvate transaminase 1;
Short=GPT 1;
AltName: Full=Glutamic--alanine transaminase 1;
AltName: Full=Glutamic--pyruvic transaminase 1;
Flags: Fragment;
Name=GPT; Synonyms=AAT1, GPT1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
PROTEIN SEQUENCE.
TISSUE=Heart;
PubMed=465450; DOI=10.1021/bi00581a015;
Tanase S., Kojima H., Morino Y.;
"Pyridoxal 5'-phosphate binding site of pig heart alanine
aminotransferase.";
Biochemistry 18:3002-3007(1979).
[2]
GLYCATION AT LYS-11.
PubMed=11330835; DOI=10.1023/A:1007280913732;
Beranek M., Drsata J., Palicka V.;
"Inhibitory effect of glycation on catalytic activity of alanine
aminotransferase.";
Mol. Cell. Biochem. 218:35-39(2001).
-!- FUNCTION: Catalyzes the reversible transamination between alanine
and 2-oxoglutarate to form pyruvate and glutamate. Participates in
cellular nitrogen metabolism and also in liver gluconeogenesis
starting with precursors transported from skeletal muscles (By
similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=2-oxoglutarate + L-alanine = L-glutamate + pyruvate;
Xref=Rhea:RHEA:19453, ChEBI:CHEBI:15361, ChEBI:CHEBI:16810,
ChEBI:CHEBI:29985, ChEBI:CHEBI:57972; EC=2.6.1.2;
-!- COFACTOR:
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
-!- PATHWAY: Amino-acid degradation; L-alanine degradation via
transaminase pathway; pyruvate from L-alanine: step 1/1.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- PTM: Glycation of Lys-11 inactivates the enzyme.
-!- SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent
aminotransferase family. Alanine aminotransferase subfamily.
{ECO:0000305}.
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PIR; A14344; A14344.
UniGene; Ssc.48536; -.
STRING; 9823.ENSSSCP00000006308; -.
PaxDb; P13191; -.
PeptideAtlas; P13191; -.
PRIDE; P13191; -.
eggNOG; KOG0258; Eukaryota.
eggNOG; COG0436; LUCA.
OrthoDB; EOG091G0PY3; -.
SABIO-RK; P13191; -.
UniPathway; UPA00528; UER00586.
Proteomes; UP000008227; Unplaced.
Genevisible; P13191; SS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC.
GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
1: Evidence at protein level;
Aminotransferase; Complete proteome; Cytoplasm;
Direct protein sequencing; Glycation; Glycoprotein;
Pyridoxal phosphate; Reference proteome; Transferase.
CHAIN <1 >20 Alanine aminotransferase 1.
/FTId=PRO_0000123935.
MOD_RES 11 11 N6-(pyridoxal phosphate)lysine.
CARBOHYD 11 11 N-linked (Glc) (glycation) lysine; in
vitro. {ECO:0000269|PubMed:11330835}.
NON_TER 1 1
NON_TER 20 20
SEQUENCE 20 AA; 2218 MW; 1C2243A373EC4801 CRC64;
QELASFHSVS KGFMGECGFR


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Catalog number Product name Quantity
E0207h ELISA kit AAT1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1,Homo sapiens,Human 96T
U0207h CLIA AAT1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1,Homo sapiens,Human 96T
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U0207r CLIA Aat1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,Gpt,GPT 1,Gpt1,Rat,Rattus norvegicus 96T
E0207r ELISA Aat1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,Gpt,GPT 1,Gpt1,Rat,Rattus norvegicus 96T
E0207r ELISA kit Aat1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,Gpt,GPT 1,Gpt1,Rat,Rattus norvegicus 96T
E0207b ELISA kit Alanine aminotransferase 1,ALT1,Bos taurus,Bovine,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1 96T
U0207m CLIA Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,Gpt,GPT 1,Gpt1,Mouse,Mus musculus 96T
E0207m ELISA kit Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,Gpt,GPT 1,Gpt1,Mouse,Mus musculus 96T
U0207b CLIA Alanine aminotransferase 1,ALT1,Bos taurus,Bovine,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1 96T
E0207p ELISA kit AAT1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1,Pig,Sus scrofa 96T
U0207p CLIA AAT1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1,Pig,Sus scrofa 96T
E0207p ELISA AAT1,Alanine aminotransferase 1,ALT1,Glutamate pyruvate transaminase 1,Glutamic--alanine transaminase 1,Glutamic--pyruvic transaminase 1,GPT,GPT 1,GPT1,Pig,Sus scrofa 96T
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10-663-45306 Alanine Aminotransferase (ALT_SGPT) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 3 U
10-663-45306 Alanine Aminotransferase (ALT_SGPT) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 50 Unit
10-663-45306 Alanine Aminotransferase (ALT_SGPT) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 1 Units
10-663-45117 Angiopoietin-like Protein 3 (ANGPTL3) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 0.01 mg
10-663-45117 Angiopoietin-like Protein 3 (ANGPTL3) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 1 mg
10-663-45118 Angiopoietin-like Protein 4 (ANGPTL4) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 1 mg
10-663-45118 Angiopoietin-like Protein 4 (ANGPTL4) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 0.002 mg
10-663-45117 Angiopoietin-like Protein 3 (ANGPTL3) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 0.002 mg
10-663-45118 Angiopoietin-like Protein 4 (ANGPTL4) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 0.01 mg
10-663-45241 Angiopoietin-2 (ANG-2) Human - EC 2.6.1.2; ALT1; Glutamic--pyruvic transaminase 1; GPT 1; Glutamic--alanine transaminase 1 N_A 0.01 mg


 

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