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Aldehyde dehydrogenase, dimeric NADP-preferring (EC 1.2.1.5) (ALDHIII) (Aldehyde dehydrogenase 3) (Aldehyde dehydrogenase family 3 member A1)

 AL3A1_CANLF             Reviewed;         453 AA.
A3RF36;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 1.
10-MAY-2017, entry version 58.
RecName: Full=Aldehyde dehydrogenase, dimeric NADP-preferring;
EC=1.2.1.5;
AltName: Full=ALDHIII;
AltName: Full=Aldehyde dehydrogenase 3;
AltName: Full=Aldehyde dehydrogenase family 3 member A1;
Name=ALDH3A1; Synonyms=ALDH3;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Cornea;
Wistow G.;
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: ALDHs play a major role in the detoxification of
alcohol-derived acetaldehyde (Probable). They are involved in the
metabolism of corticosteroids, biogenic amines, neurotransmitters,
and lipid peroxidation (Probable). Oxidizes medium and long chain
aldehydes into non-toxic fatty acids (By similarity).
Preferentially oxidizes aromatic aldehyde substrates (By
similarity). Comprises about 50 percent of corneal epithelial
soluble proteins (By similarity). May play a role in preventing
corneal damage caused by ultraviolet light (By similarity).
{ECO:0000250|UniProtKB:P30838, ECO:0000250|UniProtKB:P47739,
ECO:0000305}.
-!- CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = a
carboxylate + NAD(P)H.
-!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P30838}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47739}.
-!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
{ECO:0000305}.
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EMBL; EF382362; ABN70935.1; -; mRNA.
RefSeq; NP_001075889.1; NM_001082420.1.
UniGene; Cfa.22321; -.
ProteinModelPortal; A3RF36; -.
SMR; A3RF36; -.
STRING; 9615.ENSCAFP00000026805; -.
PaxDb; A3RF36; -.
PRIDE; A3RF36; -.
GeneID; 489526; -.
KEGG; cfa:489526; -.
CTD; 218; -.
eggNOG; KOG2456; Eukaryota.
eggNOG; COG1012; LUCA.
HOVERGEN; HBG050483; -.
InParanoid; A3RF36; -.
KO; K00129; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:UniProtKB-EC.
GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
Gene3D; 3.40.605.10; -; 1.
InterPro; IPR016161; Ald_DH/histidinol_DH.
InterPro; IPR016160; Ald_DH_CS_CYS.
InterPro; IPR029510; Ald_DH_CS_GLU.
InterPro; IPR016162; Ald_DH_N.
InterPro; IPR015590; Aldehyde_DH_dom.
InterPro; IPR012394; Aldehyde_DH_NAD(P).
Pfam; PF00171; Aldedh; 1.
PIRSF; PIRSF036492; ALDH; 1.
SUPFAM; SSF53720; SSF53720; 1.
PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
2: Evidence at transcript level;
Acetylation; Complete proteome; Cytoplasm; NAD; NADP; Oxidoreductase;
Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P30838}.
CHAIN 2 453 Aldehyde dehydrogenase, dimeric NADP-
preferring.
/FTId=PRO_0000289586.
NP_BIND 188 193 NAD or NADP. {ECO:0000250}.
ACT_SITE 210 210 {ECO:0000250}.
ACT_SITE 244 244 {ECO:0000250}.
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:P30838}.
MOD_RES 178 178 N6-acetyllysine.
{ECO:0000250|UniProtKB:P30838}.
MOD_RES 194 194 N6-acetyllysine.
{ECO:0000250|UniProtKB:P30838}.
SEQUENCE 453 AA; 50713 MW; E986E2EF8D8AE46A CRC64;
MSKISEVVQR ARAAFNSGKT RPLQFRIQQL EALRRMIKEH EKDLAGALTA DLHKNEWNAY
YEEVVYVLEE IEYMIKKLPE WAADEPVEKT PQTQQDECYI HSEPLGVVLI IGTWNYPFTV
TIQPMVGAIA AGNAVVIKPS ELSENMANLL ATIIPQYLDR DLYPVISGGI PETTELLKER
FDHILYTGNT AVGKVIMMAA AKHLTPVTLE LGGKNPCYVD KDCDLDIACR RIAWGKFMNS
GQTCVAPDYI LCDPSIQNQI VEKLKKALKE FYGEDAKKSR DYGRIINSRH FQRVMGLMEG
QKVAYGGTGD AATRYIAPTI LIDVDTQSQV MQEEIFGPVM PIVCVRSLEE AIQFINQREK
PLALYVFSLN DKMIKKMIAE TSSGGVTAND VIVHVSVHSL PYGGVGNSGM GSYHGKKSFE
TFSHCRSCLV RPLLNDESLK TRYPPSLAKM TRH


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