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Aldo-keto reductase family 1 member C21 (EC 1.1.1.-) (17-alpha-hydroxysteroid dehydrogenase) (17-alpha-HSD) (3(or 17)-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.209) (3-alpha-hydroxysteroid dehydrogenase)

 AK1CL_RAT               Reviewed;         318 AA.
Q6AYQ2;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
13-SEP-2004, sequence version 1.
12-SEP-2018, entry version 96.
RecName: Full=Aldo-keto reductase family 1 member C21;
EC=1.1.1.-;
AltName: Full=17-alpha-hydroxysteroid dehydrogenase;
Short=17-alpha-HSD;
AltName: Full=3(or 17)-alpha-hydroxysteroid dehydrogenase;
EC=1.1.1.209;
AltName: Full=3-alpha-hydroxysteroid dehydrogenase;
Name=Akr1c21;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: NADP-dependent 17-alpha-hydroxysteroid dehydrogenase
that converts 5-alpha-androstane-3,17-dione into androsterone. Has
lower 3-alpha-hydroxysteroid dehydrogenase activity. Has broad
substrate specificity and acts on various 17-alpha-
hydroxysteroids, 17-ketosteroids, 3-alpha hydroxysteroids and 3-
ketosteroids. Reduction of keto groups is strictly
stereoselective. Reduction of 17-ketosteroids yields only 17-
alpha-hydroxysteroids. Likewise, reduction of 3-ketosteroids
yields only 3-alpha-hydroxysteroids (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY: Androsterone + NAD(P)(+) = 5-alpha-androstane-
3,17-dione + NAD(P)H.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the aldo/keto reductase family.
{ECO:0000305}.
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EMBL; BC078957; AAH78957.1; -; mRNA.
RefSeq; NP_001013075.1; NM_001013057.1.
UniGene; Rn.139229; -.
ProteinModelPortal; Q6AYQ2; -.
SMR; Q6AYQ2; -.
STRING; 10116.ENSRNOP00000045355; -.
iPTMnet; Q6AYQ2; -.
PhosphoSitePlus; Q6AYQ2; -.
PaxDb; Q6AYQ2; -.
PRIDE; Q6AYQ2; -.
Ensembl; ENSRNOT00000051342; ENSRNOP00000045355; ENSRNOG00000029844.
GeneID; 291283; -.
KEGG; rno:291283; -.
UCSC; RGD:1311841; rat.
CTD; 1646; -.
RGD; 1311841; Akr1c21.
eggNOG; KOG1577; Eukaryota.
eggNOG; COG0656; LUCA.
GeneTree; ENSGT00760000119041; -.
HOGENOM; HOG000250272; -.
HOVERGEN; HBG000020; -.
InParanoid; Q6AYQ2; -.
PhylomeDB; Q6AYQ2; -.
TreeFam; TF106492; -.
Reactome; R-RNO-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
Reactome; R-RNO-193775; Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
Reactome; R-RNO-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
Reactome; R-RNO-2162123; Synthesis of Prostaglandins (PG) and Thromboxanes (TX).
Reactome; R-RNO-5365859; RA biosynthesis pathway.
Reactome; R-RNO-975634; Retinoid metabolism and transport.
PRO; PR:Q6AYQ2; -.
Proteomes; UP000002494; Chromosome 17.
Bgee; ENSRNOG00000029844; Expressed in 3 organ(s), highest expression level in liver.
ExpressionAtlas; Q6AYQ2; baseline.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0047023; F:androsterone dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
CDD; cd06660; Aldo_ket_red; 1.
Gene3D; 3.20.20.100; -; 1.
InterPro; IPR018170; Aldo/ket_reductase_CS.
InterPro; IPR020471; Aldo/keto_reductase.
InterPro; IPR023210; NADP_OxRdtase_dom.
InterPro; IPR036812; NADP_OxRdtase_dom_sf.
PANTHER; PTHR11732; PTHR11732; 1.
Pfam; PF00248; Aldo_ket_red; 1.
PIRSF; PIRSF000097; AKR; 1.
PRINTS; PR00069; ALDKETRDTASE.
SUPFAM; SSF51430; SSF51430; 1.
PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Lipid metabolism; NADP; Oxidoreductase;
Reference proteome; Steroid metabolism.
CHAIN 1 318 Aldo-keto reductase family 1 member C21.
/FTId=PRO_0000326223.
NP_BIND 20 24 NADP. {ECO:0000250}.
NP_BIND 166 167 NADP. {ECO:0000250}.
NP_BIND 216 224 NADP. {ECO:0000250}.
NP_BIND 270 280 NADP. {ECO:0000250}.
ACT_SITE 55 55 Proton donor. {ECO:0000250}.
BINDING 31 31 Substrate. {ECO:0000250}.
BINDING 50 50 NADP. {ECO:0000250}.
BINDING 117 117 Substrate. {ECO:0000250}.
BINDING 190 190 NADP. {ECO:0000250}.
SITE 84 84 Lowers pKa of active site Tyr.
{ECO:0000250}.
SEQUENCE 318 AA; 36135 MW; 53909644919456D1 CRC64;
MNSKCHCVKL NDGHFIPVLG FGTAMPSELP KSKAKEVTKI AIDAGFHHFD SAFVYNTEDH
VGEAIREKIA NGTTRREDIF YTSKLWCTSL HPELVRSSLE CSLKKLQLDY VDLYLIHFPM
ALKPGDENFP VDEHGKLLFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNR RQLEKILNKP
GLKYKPVCNQ VECHLYLNQM KLLDFCKTNG IILVAYGVLG TQRYNGWVDQ NSPVLLNEPV
LSSMAKKYNQ TPALIALRHQ LQRGIVVLNT SLKEERIKEN MKLSPEDMKV LDDLNRNLRY
IAGGIFEGHP NFPFLDEY


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