Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Alpha/kappa-conotoxin pl14a

 CJEA_CONPO              Reviewed;          76 AA.
Q0N4U8;
14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
19-SEP-2006, sequence version 1.
15-MAR-2017, entry version 40.
RecName: Full=Alpha/kappa-conotoxin pl14a;
Flags: Precursor;
Conus planorbis (Planorbis cone).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Conidae;
Conus.
NCBI_TaxID=97183;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-64, SYNTHESIS OF
40-64, MASS SPECTROMETRY, AMIDATION AT ARG-64, DISULFIDE BONDS, AND
STRUCTURE BY NMR OF 40-64.
TISSUE=Venom, and Venom duct;
PubMed=16819832; DOI=10.1021/bi060263r;
Imperial J.S., Bansal P.S., Alewood P.F., Daly N.L., Craik D.J.,
Sporning A., Terlau H., Lopez-Vera E., Bandyopadhyay P.K.,
Olivera B.M.;
"A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes
defines a new superfamily of conotoxins.";
Biochemistry 45:8331-8340(2006).
-!- FUNCTION: Highly inhibits both nicotinic acetylcholine receptors
(neuronal (IC(50)=8.7 uM for alpha-3/beta-4) and neuromuscular
(IC(50)=0.54 uM for alpha-1/beta-1/epsilon/delta) subtypes) and
the voltage-gated potassium channel Kv1.6/KCNA6 subtype
(IC(50)=1.59 uM).
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom duct.
-!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
-!- MASS SPECTROMETRY: Mass=2909.5; Method=Electrospray; Range=40-64;
Evidence={ECO:0000269|PubMed:16819832};
-!- MISCELLANEOUS: No or very small inhibition is observed on
Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5
and Nav1.2/SCN2A. {ECO:0000305|PubMed:16819832}.
-!- SIMILARITY: Belongs to the conotoxin J superfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; DQ447640; ABE27006.1; -; mRNA.
PDB; 2FQC; NMR; -; A=40-64.
PDB; 2NAV; NMR; -; A=53-64.
PDB; 2NAW; NMR; -; A=54-64.
PDBsum; 2FQC; -.
PDBsum; 2NAV; -.
PDBsum; 2NAW; -.
ProteinModelPortal; Q0N4U8; -.
SMR; Q0N4U8; -.
ConoServer; 1183; PlXIVA precursor.
EvolutionaryTrace; Q0N4U8; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0035792; C:other organism postsynaptic membrane; IEA:UniProtKB-KW.
1: Evidence at protein level;
3D-structure; Acetylcholine receptor inhibiting toxin; Amidation;
Direct protein sequencing; Disulfide bond;
Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
Potassium channel impairing toxin; Secreted; Signal; Toxin;
Voltage-gated potassium channel impairing toxin.
SIGNAL 1 24 {ECO:0000255}.
PROPEP 25 39 {ECO:0000269|PubMed:16819832}.
/FTId=PRO_0000260006.
PEPTIDE 40 64 Alpha/kappa-conotoxin pl14a.
/FTId=PRO_0000260007.
PROPEP 65 76
/FTId=PRO_0000260008.
MOD_RES 64 64 Arginine amide.
{ECO:0000269|PubMed:16819832}.
DISULFID 46 61 {ECO:0000269|PubMed:16819832}.
DISULFID 50 63 {ECO:0000269|PubMed:16819832}.
HELIX 44 52 {ECO:0000244|PDB:2FQC}.
HELIX 54 56 {ECO:0000244|PDB:2FQC}.
HELIX 59 61 {ECO:0000244|PDB:2FQC}.
SEQUENCE 76 AA; 8298 MW; 3664513E79382249 CRC64;
MPSVRSVTCC CLLWMMFSVQ LVTPGSPGTA QLSGHRTARF PRPRICNLAC RAGIGHKYPF
CHCRGKRDAV SSSMAV


Related products :

Catalog number Product name Quantity
08CON015-01000 α-conotoxin GI (alpha conotoxin GI), α-conotoxin G blocks nAChR receptors 1000 ug
08CON015-00500 α-conotoxin GI (alpha conotoxin GI), α-conotoxin G blocks nAChR receptors 500 ug
08CON012-01000 α-conotoxin MI (alpha conotoxin MI), α-conotoxin MI blocks nAChR 1000 ug
08CON011-00500 α-conotoxin IMI (alpha conotoxin IMI), α-conotoxin IMI blocks nAChR 500 ug
08CON012-00500 α-conotoxin MI (alpha conotoxin MI), α-conotoxin MI blocks nAChR 500 ug
08CON011-01000 α-conotoxin IMI (alpha conotoxin IMI), α-conotoxin IMI blocks nAChR 1000 ug
orb72044 alpha Conotoxin GI peptide This is alpha Conotoxin GI peptide. For research use only. 0.5 mg
orb71258 alpha Conotoxin GS peptide This is alpha Conotoxin GS peptide. For research use only. 1 mg
orb72045 alpha Conotoxin IMI peptide This is alpha Conotoxin IMI peptide. For research use only. 0.5 mg
orb71260 alpha Conotoxin SIA peptide This is alpha Conotoxin SIA peptide. For research use only. 1 mg
orb71259 alpha Conotoxin MI peptide This is alpha Conotoxin MI peptide. For research use only. 1 mg
orb70283 alpha Conotoxin SI peptide This is alpha Conotoxin SI peptide. For research use only. 1 mg
orb71257 alpha Conotoxin EI peptide This is alpha Conotoxin EI peptide. For research use only. 1 mg
08CON001-00100 ω-Conotoxin MVIIA (omega conotoxin MVIIA), ω-Conotoxin MVIIA is a Cav2.2 channel blocker 100 ug
08CON001-00500 ω-Conotoxin MVIIA (omega conotoxin MVIIA), ω-Conotoxin MVIIA is a Cav2.2 channel blocker 500 ug
18-003-43046 NF-kappa-B inhibitor alpha - Major histocompatibility complex enhancer-binding protein MAD3; I-kappa-B-alpha; IkappaBalpha; IKB-alpha Polyclonal 0.05 mg Aff Pur
E1848r ELISA kit IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,NF-kappa-B inhibitor alpha,Nfkbia,Rat,Rattus norvegicus,RL_IF-1 96T
U1848r CLIA kit IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,NF-kappa-B inhibitor alpha,Nfkbia,Rat,Rattus norvegicus,RL_IF-1 96T
E1848r ELISA IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,NF-kappa-B inhibitor alpha,Nfkbia,Rat,Rattus norvegicus,RL_IF-1 96T
U1848r CLIA IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,NF-kappa-B inhibitor alpha,Nfkbia,Rat,Rattus norvegicus,RL_IF-1 96T
U1848m CLIA IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,Mouse,Mus musculus,NF-kappa-B inhibitor alpha,Nfkbia 96T
E1848m ELISA IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,Mouse,Mus musculus,NF-kappa-B inhibitor alpha,Nfkbia 96T
E1848m ELISA kit IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,Mouse,Mus musculus,NF-kappa-B inhibitor alpha,Nfkbia 96T
U1848m CLIA kit IkappaBalpha,I-kappa-B-alpha,Ikba,IkB-alpha,Mouse,Mus musculus,NF-kappa-B inhibitor alpha,Nfkbia 96T
U1848p CLIA kit ECI-6,IkappaBalpha,I-kappa-B-alpha,IKBA,IkB-alpha,NF-kappa-B inhibitor alpha,NFKBIA,Pig,Sus scrofa 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur