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Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start

 C4R3H4_KOMPG            Unreviewed;       303 AA.
C4R3H4;
07-JUL-2009, integrated into UniProtKB/TrEMBL.
07-JUL-2009, sequence version 1.
28-FEB-2018, entry version 58.
SubName: Full=Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start {ECO:0000313|EMBL:CAY70009.1};
OrderedLocusNames=PAS_chr3_0077 {ECO:0000313|EMBL:CAY70009.1};
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia
pastoris).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Komagataella.
NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70009.1, ECO:0000313|Proteomes:UP000000314};
[1] {ECO:0000313|EMBL:CAY70009.1, ECO:0000313|Proteomes:UP000000314}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
PubMed=19465926; DOI=10.1038/nbt.1544;
De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
"Genome sequence of the recombinant protein production host Pichia
pastoris.";
Nat. Biotechnol. 27:561-566(2009).
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EMBL; FN392321; CAY70009.1; -; Genomic_DNA.
RefSeq; XP_002492289.1; XM_002492244.1.
ProteinModelPortal; C4R3H4; -.
DIP; DIP-61964N; -.
IntAct; C4R3H4; 1.
STRING; 644223.XP_002492289.1; -.
EnsemblFungi; CAY70009; CAY70009; PAS_chr3_0077.
GeneID; 8199362; -.
KEGG; ppa:PAS_chr3_0077; -.
eggNOG; KOG2916; Eukaryota.
eggNOG; COG1093; LUCA.
HOGENOM; HOG000199476; -.
InParanoid; C4R3H4; -.
KO; K03237; -.
OMA; KDVNEHQ; -.
OrthoDB; EOG092C3ENF; -.
Proteomes; UP000000314; Chromosome 3.
GO; GO:0010494; C:cytoplasmic stress granule; IEA:EnsemblFungi.
GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:EnsemblFungi.
GO; GO:0005850; C:eukaryotic translation initiation factor 2 complex; IEA:EnsemblFungi.
GO; GO:0043614; C:multi-eIF complex; IEA:EnsemblFungi.
GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO; GO:0001731; P:formation of translation preinitiation complex; IEA:EnsemblFungi.
GO; GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:EnsemblFungi.
Gene3D; 1.10.150.190; -; 1.
Gene3D; 3.30.70.1130; -; 1.
InterPro; IPR012340; NA-bd_OB-fold.
InterPro; IPR022967; S1_dom.
InterPro; IPR003029; S1_domain.
InterPro; IPR024055; TIF2_asu_C.
InterPro; IPR024054; TIF2_asu_middle_sf.
InterPro; IPR011488; TIF_2_asu.
PANTHER; PTHR10602; PTHR10602; 1.
Pfam; PF07541; EIF_2_alpha; 1.
Pfam; PF00575; S1; 1.
SMART; SM00316; S1; 1.
SUPFAM; SSF110993; SSF110993; 1.
SUPFAM; SSF116742; SSF116742; 1.
SUPFAM; SSF50249; SSF50249; 1.
PROSITE; PS50126; S1; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000000314};
Initiation factor {ECO:0000313|EMBL:CAY70009.1};
Protein biosynthesis {ECO:0000313|EMBL:CAY70009.1};
Reference proteome {ECO:0000313|Proteomes:UP000000314}.
DOMAIN 17 88 S1 motif. {ECO:0000259|PROSITE:PS50126}.
SEQUENCE 303 AA; 34363 MW; 628180135C134A38 CRC64;
MSTSTCRFYE NKYPEVDDVV MVNVQQIAEM GAYVKLLEYD NIEGMVLLSE LSRRRIRSIQ
KLIRVGKNEV VVVLRVDKEK GYIDLSKRRV SSEDIAKCEE RYTKSKSVHS ILRHCAEKFN
MPLEELYRTI GWPLSKEFGH AYDAFKISIT DSTVFDKVQP PSQEVLEELK VYISRRLTPQ
AIKCRADVEV SCFSYEGIEA IKSSLKAAED ISTEANQVKV KLVAAPLYVI TTQSLDKTQG
IEILERAIKI IEDSITKQGG SCNVTMAPKA VTATEDAELQ ALMERKENED KVSDEDSDLD
EED


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