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Alpha-2 macroglobulin-like protein

 B8QSI4_DANRE            Unreviewed;      1442 AA.
B8QSI4;
03-MAR-2009, integrated into UniProtKB/TrEMBL.
03-MAR-2009, sequence version 1.
23-MAY-2018, entry version 68.
SubName: Full=Alpha-2 macroglobulin-like protein {ECO:0000313|EMBL:ACG70183.1};
Name=a2ml {ECO:0000313|ZFIN:ZDB-GENE-090212-1};
Synonyms=A2ML {ECO:0000313|EMBL:ACG70183.1};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:ACG70183.1};
[1] {ECO:0000313|EMBL:ACG70183.1}
NUCLEOTIDE SEQUENCE.
Hong S.-K., Dawid I.B.;
"Zebrafish alpha-2 macroglobulin-like (A2ML) is required for early
liver development.";
PLoS ONE 3:E3736-E3736(2008).
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EMBL; EU689051; ACG70183.1; -; mRNA.
RefSeq; NP_001132951.1; NM_001139479.1.
UniGene; Dr.75455; -.
PeptideAtlas; B8QSI4; -.
PRIDE; B8QSI4; -.
GeneID; 100006972; -.
KEGG; dre:100006972; -.
CTD; 100006972; -.
ZFIN; ZDB-GENE-090212-1; a2ml.
eggNOG; ENOG410KCRJ; Eukaryota.
eggNOG; COG2373; LUCA.
HOGENOM; HOG000220939; -.
HOVERGEN; HBG000039; -.
InParanoid; B8QSI4; -.
KO; K03910; -.
TreeFam; TF313285; -.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
GO; GO:0001889; P:liver development; IMP:ZFIN.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 2.60.40.690; -; 1.
InterPro; IPR009048; A-macroglobulin_rcpt-bd.
InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
InterPro; IPR011626; A2M_comp.
InterPro; IPR002890; A2M_N.
InterPro; IPR011625; A2M_N_2.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR001599; Macroglobln_a2.
InterPro; IPR019742; MacrogloblnA2_CS.
InterPro; IPR019565; MacrogloblnA2_thiol-ester-bond.
InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
Pfam; PF00207; A2M; 1.
Pfam; PF07678; A2M_comp; 1.
Pfam; PF01835; A2M_N; 1.
Pfam; PF07703; A2M_N_2; 1.
Pfam; PF07677; A2M_recep; 1.
Pfam; PF10569; Thiol-ester_cl; 1.
SMART; SM01360; A2M; 1.
SMART; SM01359; A2M_N_2; 1.
SMART; SM01361; A2M_recep; 1.
SUPFAM; SSF48239; SSF48239; 1.
SUPFAM; SSF49410; SSF49410; 1.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
2: Evidence at transcript level;
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 1442 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5002877793.
DOMAIN 459 609 A2M_N_2. {ECO:0000259|SMART:SM01359}.
DOMAIN 729 818 A2M. {ECO:0000259|SMART:SM01360}.
DOMAIN 1341 1431 A2M_recep. {ECO:0000259|SMART:SM01361}.
SEQUENCE 1442 AA; 159809 MW; 3B7E41BED8D09434 CRC64;
MALNVSCCWK GLLLNFFLFV CVNGQAAEPS FMVTFPAVIE SGSEAKLCAS LLKPNESLVM
NIYLVHGNQS TLLLQENAEQ EFHRCFNFKA PLAEAESVQK IKVELQGESF KMTEERKVMF
KSYDPLTFIQ TDKPIYMPGQ IVNFRVVTMD TNFAPVDQQY SIIVLEDSQD NRIGQWTNVS
STRWILQRSY ELNPECREGA YKLKAFIGER MSSHYFQVKK YVLPKFEVTV KKPKTVSVVE
EELLIEVCAK YTYGQPVPGK SWVKVCRNPL PYIIFFPLCL EETLEITKTG CAIHNFGLSM
ILNSTLKDNL KDSLHVEAVV TEEGTEITMT KSESVHLTYE IGKITLIDLP KTYEPGSVIE
GKIKLSDFKD APIPNKEVYL LEGENWSSKL LLNLTTDSDG LASFSLNTSS LSKKDISLIA
NVYPDTRYYG YKTPYFSTDK KTVQLFRIAT VYSPTLSELI IEDIEQPLKC GTEITATVKY
YFVGETVEDF STDIVYMVLS RGVIVHHGFE KVEVKSSSNG LASGTMSFKL SVGADVAPVV
QILAYCVLPS ENVIAANKRL DTEKCFGNKV SLQFSPAKAV PGEKNTLQLS AQPGSLCGLS
AVDQSVLILE SGKRLDADKI FNLLPVQSVS YYPYSVEDEQ ACLYVRPRRS VLTDNTYETL
KSVGLKMATN LAVRVPDCLS YRGLTYHKNL VMYPDHRPVP VMFALGMAGV DGPVGNSPSV
TIRTVFPETW IWELAEVGDS GSAEVPVTVP DTITTWETEA FCLSSTGLGL APPAQLTVFQ
PFFLELSLPY SIIRGEIFEL KATVFNYLSK CIMVKVSPAP SSDYTLKASS DDQYSSCLCA
NGRKTFKWIL TPSVLGVVNV TVSAEAEASQ TVCDNEIVSV PERGRIDIVT RSLLVQAEGI
EKTETNSWLL CPKGDSLSEK VDLTLPKDVI EGSAKSSVSV IGDILGRALQ NLHGLLRMPY
GCGEQNMAVL SPNIYILQYL ENTKQLTSAI REKASSFLKS GYQRQLNYKH FDGAYSTFGY
GDGNTWLTAF VLRSFGKAQK YTFIDPQIIQ SAKDWLISRR DSDGCFIQQG RLFNNRMKGG
VNDNVTMTAY ITASLLELET PVTDPVITKG LSCLRSVIEE VKNTYTTALL AYTFSLARDT
NTRQQLFNKL EDLAISDGPL VHWSRSASAD DSASLDVEIS SYVLLAVLTA DSLTTADLGF
ANRIVSWLVK QQNAYGGFSS TQDTVVALQA LSLYATKVFS SDGSSTVTVQ SAGDSHHFDV
NQDNKLLYQE KQLANVPGKY SIEVKGSACV SVQIAQFYNI PTPTEAKTLS IDAKIEGDCE
ALGQNFIFDF TVKYDGPEEK TNMAIVDIKL LSGFTADTSA LGTSSGTYVS LVERVDSKDD
HVIVYLKEIS KNVAMNYQIQ MKQVLQVKNL KPAVVKVYDY YQTSDQSEIE YSFHCEALKN
IN


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