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Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9)

 A2ML1_HUMAN             Reviewed;        1454 AA.
A8K2U0; B5MDD1; B7Z7V4; D3DUV3; F5H2Z2; Q2M224; Q6ZW52; Q6ZW53;
Q8N1M4; Q96LQ8;
05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 3.
18-JUL-2018, entry version 94.
RecName: Full=Alpha-2-macroglobulin-like protein 1;
AltName: Full=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9;
Flags: Precursor;
Name=A2ML1 {ECO:0000312|EMBL:AAI12132.1};
Synonyms=CPAMD9 {ECO:0000312|HGNC:HGNC:23336};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1] {ECO:0000312|EMBL:BAF83044.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
VARIANTS GLU-850; TRP-1122; ARG-1229; VAL-1257 AND MET-1312.
TISSUE=Brain {ECO:0000312|EMBL:BAB71612.1}, Testis, and
Tongue {ECO:0000312|EMBL:BAF83044.1};
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
GLU-850; TRP-1122; ARG-1229 AND VAL-1257.
TISSUE=Cervix;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS GLU-850;
TRP-1122; ARG-1229 AND VAL-1257.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-1454.
TISSUE=Brain {ECO:0000312|EMBL:AAI12132.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
PubMed=16298998; DOI=10.1074/jbc.M508017200;
Galliano M.-F., Toulza E., Gallinaro H., Jonca N., Ishida-Yamamoto A.,
Serre G., Guerrin M.;
"A novel protease inhibitor of the alpha2-macroglobulin family
expressed in the human epidermis.";
J. Biol. Chem. 281:5780-5789(2006).
-!- FUNCTION: Is able to inhibit all four classes of proteinases by a
unique 'trapping' mechanism. This protein has a peptide stretch,
called the 'bait region' which contains specific cleavage sites
for different proteinases. When a proteinase cleaves the bait
region, a conformational change is induced in the protein which
traps the proteinase. The entrapped enzyme remains active against
low molecular weight substrates (activity against high molecular
weight substrates is greatly reduced). Following cleavage in the
bait region a thioester bond is hydrolyzed and mediates the
covalent binding of the protein to the proteinase (By similarity).
Displays inhibitory activity against chymotrypsin, papain,
thermolysin, subtilisin A and, to a lesser extent, elastase but
not trypsin. May play an important role during desquamation by
inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023,
ECO:0000269|PubMed:16298998}.
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16298998}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16298998}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=A8K2U0-1; Sequence=Displayed;
Name=2;
IsoId=A8K2U0-2; Sequence=VSP_057135;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: In the epidermis, expressed predominantly in
the granular layer at the apical edge of keratinocytes (at protein
level). Also detected in placenta, testis and thymus but not in
epithelia of kidney, lung, small intestine or colon.
{ECO:0000269|PubMed:16298998}.
-!- DEVELOPMENTAL STAGE: Up-regulated during keratinocyte
differentiation. {ECO:0000269|PubMed:16298998}.
-!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
macroglobulin) family. {ECO:0000255}.
-!- SEQUENCE CAUTION:
Sequence=BAB71612.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAC04793.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAC85653.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAC85654.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AK057908; BAB71612.1; ALT_INIT; mRNA.
EMBL; AK096448; BAC04793.1; ALT_INIT; mRNA.
EMBL; AK123591; BAC85653.1; ALT_INIT; mRNA.
EMBL; AK123592; BAC85654.1; ALT_INIT; mRNA.
EMBL; AK290355; BAF83044.1; -; mRNA.
EMBL; AK302555; BAH13740.1; -; mRNA.
EMBL; AL832139; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AC006513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC006581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471116; EAW88603.1; -; Genomic_DNA.
EMBL; CH471116; EAW88606.1; -; Genomic_DNA.
EMBL; BC093840; AAH93840.2; -; mRNA.
EMBL; BC112131; AAI12132.1; -; mRNA.
CCDS; CCDS73439.1; -. [A8K2U0-2]
CCDS; CCDS8596.2; -. [A8K2U0-1]
RefSeq; NP_001269353.1; NM_001282424.2.
RefSeq; XP_016874359.1; XM_017018870.1. [A8K2U0-1]
UniGene; Hs.620532; -.
ProteinModelPortal; A8K2U0; -.
SMR; A8K2U0; -.
IntAct; A8K2U0; 5.
MINT; A8K2U0; -.
STRING; 9606.ENSP00000299698; -.
MEROPS; I39.007; -.
iPTMnet; A8K2U0; -.
PhosphoSitePlus; A8K2U0; -.
EPD; A8K2U0; -.
MaxQB; A8K2U0; -.
PaxDb; A8K2U0; -.
PRIDE; A8K2U0; -.
ProteomicsDB; 1852; -.
Ensembl; ENST00000299698; ENSP00000299698; ENSG00000166535. [A8K2U0-1]
Ensembl; ENST00000539547; ENSP00000438292; ENSG00000166535. [A8K2U0-2]
GeneID; 144568; -.
KEGG; hsa:144568; -.
UCSC; uc001quz.6; human. [A8K2U0-1]
CTD; 144568; -.
DisGeNET; 144568; -.
EuPathDB; HostDB:ENSG00000166535.19; -.
GeneCards; A2ML1; -.
HGNC; HGNC:23336; A2ML1.
HPA; HPA038847; -.
HPA; HPA038848; -.
MalaCards; A2ML1; -.
MIM; 610627; gene.
neXtProt; NX_A8K2U0; -.
OpenTargets; ENSG00000166535; -.
Orphanet; 648; Noonan syndrome.
eggNOG; KOG1366; Eukaryota.
eggNOG; ENOG410XRED; LUCA.
GeneTree; ENSGT00760000118982; -.
HOVERGEN; HBG000039; -.
InParanoid; A8K2U0; -.
OMA; VSVCQKA; -.
OrthoDB; EOG091G00HD; -.
PhylomeDB; A8K2U0; -.
TreeFam; TF313285; -.
ChiTaRS; A2ML1; human.
PRO; PR:A8K2U0; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000166535; -.
CleanEx; HS_A2ML1; -.
ExpressionAtlas; A8K2U0; baseline and differential.
Genevisible; A8K2U0; HS.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0030414; F:peptidase inhibitor activity; IDA:UniProtKB.
GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
GO; GO:0052548; P:regulation of endopeptidase activity; IDA:UniProtKB.
Gene3D; 2.60.40.10; -; 2.
Gene3D; 2.60.40.690; -; 1.
InterPro; IPR009048; A-macroglobulin_rcpt-bd.
InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
InterPro; IPR011626; A2M_comp.
InterPro; IPR002890; A2M_N.
InterPro; IPR011625; A2M_N_2.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR001599; Macroglobln_a2.
InterPro; IPR019742; MacrogloblnA2_CS.
InterPro; IPR019565; MacrogloblnA2_thiol-ester-bond.
InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
Pfam; PF00207; A2M; 1.
Pfam; PF07678; A2M_comp; 1.
Pfam; PF01835; A2M_N; 1.
Pfam; PF07703; A2M_N_2; 1.
Pfam; PF07677; A2M_recep; 1.
Pfam; PF10569; Thiol-ester_cl; 1.
SMART; SM01360; A2M; 1.
SMART; SM01359; A2M_N_2; 1.
SMART; SM01361; A2M_recep; 1.
SUPFAM; SSF48239; SSF48239; 1.
SUPFAM; SSF49410; SSF49410; 1.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
1: Evidence at protein level;
Alternative splicing; Bait region; Complete proteome; Disulfide bond;
Glycoprotein; Polymorphism; Protease inhibitor; Reference proteome;
Secreted; Serine protease inhibitor; Signal; Thioester bond.
SIGNAL 1 17 {ECO:0000255}.
CHAIN 18 1454 Alpha-2-macroglobulin-like protein 1.
{ECO:0000255}.
/FTId=PRO_0000318074.
REGION 695 726 Bait region. {ECO:0000255}.
CARBOHYD 120 120 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 281 281 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 409 409 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 857 857 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1020 1020 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 40 78 {ECO:0000250|UniProtKB:P01023}.
DISULFID 241 291 {ECO:0000250|UniProtKB:P01023}.
DISULFID 259 279 {ECO:0000250|UniProtKB:P01023}.
DISULFID 464 557 {ECO:0000250|UniProtKB:P01023}.
DISULFID 589 769 {ECO:0000250|UniProtKB:P01023}.
DISULFID 819 847 {ECO:0000250|UniProtKB:P01023}.
DISULFID 845 881 {ECO:0000250|UniProtKB:P01023}.
DISULFID 919 1307 {ECO:0000250|UniProtKB:P01023}.
DISULFID 1075 1123 {ECO:0000250|UniProtKB:P01023}.
DISULFID 1338 1453 {ECO:0000250|UniProtKB:P01023}.
CROSSLNK 970 973 Isoglutamyl cysteine thioester (Cys-Gln).
{ECO:0000250|UniProtKB:P01023}.
VAR_SEQ 2 492 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_057135.
VARIANT 207 207 G -> R (in dbSNP:rs11047499).
/FTId=VAR_055463.
VARIANT 850 850 D -> E (in dbSNP:rs1860926).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:17974005,
ECO:0000269|Ref.4}.
/FTId=VAR_059083.
VARIANT 970 970 C -> Y (in dbSNP:rs1558526).
/FTId=VAR_055464.
VARIANT 1122 1122 R -> W (in dbSNP:rs1860967).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:17974005,
ECO:0000269|Ref.4}.
/FTId=VAR_071854.
VARIANT 1131 1131 T -> M (in dbSNP:rs7959680).
/FTId=VAR_055465.
VARIANT 1229 1229 H -> R (in dbSNP:rs10219561).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:17974005,
ECO:0000269|Ref.4}.
/FTId=VAR_059084.
VARIANT 1257 1257 M -> V (in dbSNP:rs7308811).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:17974005,
ECO:0000269|Ref.4}.
/FTId=VAR_071855.
VARIANT 1312 1312 T -> M (in dbSNP:rs201083574).
{ECO:0000269|PubMed:14702039}.
/FTId=VAR_071856.
VARIANT 1412 1412 T -> A (in dbSNP:rs7315591).
/FTId=VAR_055466.
CONFLICT 733 733 F -> L (in Ref. 1; BAC85654/BAF83044).
{ECO:0000305}.
CONFLICT 748 748 G -> E (in Ref. 2; AL832139).
{ECO:0000305}.
CONFLICT 1150 1150 M -> I (in Ref. 1; BAF83044).
{ECO:0000305}.
CONFLICT 1248 1248 L -> P (in Ref. 1; BAC85654).
{ECO:0000305}.
CONFLICT 1452 1452 P -> L (in Ref. 2; AL832139).
{ECO:0000305}.
SEQUENCE 1454 AA; 161107 MW; 15ED65D000834E33 CRC64;
MWAQLLLGML ALSPAIAEEL PNYLVTLPAR LNFPSVQKVC LDLSPGYSDV KFTVTLETKD
KTQKLLEYSG LKKRHLHCIS FLVPPPAGGT EEVATIRVSG VGNNISFEEK KKVLIQRQGN
GTFVQTDKPL YTPGQQVYFR IVTMDSNFVP VNDKYSMVEL QDPNSNRIAQ WLEVVPEQGI
VDLSFQLAPE AMLGTYTVAV AEGKTFGTFS VEEYVLPKFK VEVVEPKELS TVQESFLVKI
CCRYTYGKPM LGAVQVSVCQ KANTYWYREV EREQLPDKCR NLSGQTDKTG CFSAPVDMAT
FDLIGYAYSH QINIVATVVE EGTGVEANAT QNIYISPQMG SMTFEDTSNF YHPNFPFSGK
IRVRGHDDSF LKNHLVFLVI YGTNGTFNQT LVTDNNGLAP FTLETSGWNG TDVSLEGKFQ
MEDLVYNPEQ VPRYYQNAYL HLRPFYSTTR SFLGIHRLNG PLKCGQPQEV LVDYYIDPAD
ASPDQEISFS YYLIGKGSLV MEGQKHLNSK KKGLKASFSL SLTFTSRLAP DPSLVIYAIF
PSGGVVADKI QFSVEMCFDN QVSLGFSPSQ QLPGAEVELQ LQAAPGSLCA LRAVDESVLL
LRPDRELSNR SVYGMFPFWY GHYPYQVAEY DQCPVSGPWD FPQPLIDPMP QGHSSQRSII
WRPSFSEGTD LFSFFRDVGL KILSNAKIKK PVDCSHRSPE YSTAMGAGGG HPEAFESSTP
LHQAEDSQVR QYFPETWLWD LFPIGNSGKE AVHVTVPDAI TEWKAMSFCT SQSRGFGLSP
TVGLTAFKPF FVDLTLPYSV VRGESFRLTA TIFNYLKDCI RVQTDLAKSH EYQLESWADS
QTSSCLCADD AKTHHWNITA VKLGHINFTI STKILDSNEP CGGQKGFVPQ KGRSDTLIKP
VLVKPEGVLV EKTHSSLLCP KGKVASESVS LELPVDIVPD STKAYVTVLG DIMGTALQNL
DGLVQMPSGC GEQNMVLFAP IIYVLQYLEK AGLLTEEIRS RAVGFLEIGY QKELMYKHSN
GSYSAFGERD GNGNTWLTAF VTKCFGQAQK FIFIDPKNIQ DALKWMAGNQ LPSGCYANVG
NLLHTAMKGG VDDEVSLTAY VTAALLEMGK DVDDPMVSQG LRCLKNSATS TTNLYTQALL
AYIFSLAGEM DIRNILLKQL DQQAIISGES IYWSQKPTPS SNASPWSEPA AVDVELTAYA
LLAQLTKPSL TQKEIAKATS IVAWLAKQHN AYGGFSSTQD TVVALQALAK YATTAYMPSE
EINLVVKSTE NFQRTFNIQS VNRLVFQQDT LPNVPGMYTL EASGQGCVYV QTVLRYNILP
PTNMKTFSLS VEIGKARCEQ PTSPRSLTLT IHTSYVGSRS SSNMAIVEVK MLSGFSPMEG
TNQLLLQQPL VKKVEFGTDT LNIYLDELIK NTQTYTFTIS QSVLVTNLKP ATIKVYDYYL
PDEQATIQYS DPCE


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Catalog number Product name Quantity
E1017h ELISA A2M,Alpha-2-M,Alpha-2-macroglobulin,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5,CPAMD5,FWP007,Homo sapiens,Human 96T
U1017h CLIA A2M,Alpha-2-M,Alpha-2-macroglobulin,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5,CPAMD5,FWP007,Homo sapiens,Human 96T
E1017h ELISA kit A2M,Alpha-2-M,Alpha-2-macroglobulin,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5,CPAMD5,FWP007,Homo sapiens,Human 96T
orb22184 Goat Serum Against Rat Alpha-2 Macroglobulin Polyclonal Precipitating polyclonal goat antiserum to rat alpha-2 macroglobulin. Alpha-2 macroglobulin(clotting factor I) is the major protein in the alpha 1 ml
orb21961 Rabbit Serum Against Mouse Alpha-2 Macroglobulin Polyclonal Precipitating polyclonal rabbit antiserum to mouse alpha-2 macroglobulin. Alpha-2 macroglobulin ids the major protein in the alpha-2 region 1 ml
orb21931 Goat Serum Against Human Alpha-2 Macroglobulin Polyclonal Precipitating polyclonal goat antiserum to human alpha-2 macroglobulin. Alpha-2 macroglobulin(clotting factor I) is the major protein in the a 1 ml
orb82119 Human Alpha 2 Macroglobulin protein Alpha 2 Macroglobulin is a purified protein_bioactive peptide. For research use only. 1 mg
orb80896 Human Alpha-2 Macroglobulin protein Human Alpha-2 Macroglobulin is tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa. For research use only. 200
SCH-5850-2004 NATIVE HUMAN ALPHA 2 MACROGLOBULIN, Product Type Purified Protein, Specificity ALPHA 2 MACROGLOBULIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone 1 mg
5850-2004 NATIVE HUMAN ALPHA 2 MACROGLOBULIN, Product Type Purified Protein, Specificity ALPHA 2 MACROGLOBULIN, Target Species Human, Host N_A, Format Purified, Isotypes , Applications E, Clone 1 mg
EIAAB33288 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6,CPAMD6,Homo sapiens,Human,Pregnancy zone protein,PZP
gen12640 CO3_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 ELISA tesk kit 1
gen6268 CO5_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 ELISA tesk kit 1
gen13980 A2MG_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 ELISA tesk kit 1
gen6292 CO4B_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 ELISA tesk kit 1
gen6286 CO4A_HUMAN C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 ELISA tesk kit 1
CSB-EL005881HU Human C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8(CPAMD8) ELISA kit 96T
CSB-EL005881HU Human C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8(CPAMD8) ELISA kit SpeciesHuman 96T
EIAAB09068 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8,CPAMD8,Homo sapiens,Human,KIAA1283
CPMD8_HUMAN ELISA Kit FOR C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; organism: Human; gene name: CPAMD8 96T
E0861h ELISA C3,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1,Complement C3,CPAMD1,Homo sapiens,Human 96T
U1969h CLIA kit C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4,C5,Complement C5,CPAMD4,Homo sapiens,Human 96T
E1969h ELISA kit C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4,C5,Complement C5,CPAMD4,Homo sapiens,Human 96T
U0861h CLIA C3,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1,Complement C3,CPAMD1,Homo sapiens,Human 96T
E1969h ELISA C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4,C5,Complement C5,CPAMD4,Homo sapiens,Human 96T


 

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