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Alpha-synuclein

 F6U044_HORSE            Unreviewed;       140 AA.
F6U044;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
30-AUG-2017, entry version 45.
RecName: Full=Alpha-synuclein {ECO:0000256|RuleBase:RU361225};
Name=SNCA {ECO:0000313|Ensembl:ENSECAP00000013335};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013335, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000013335, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013335,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000013335}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013335};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the synuclein family.
{ECO:0000256|RuleBase:RU361225}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSECAP00000013335}.
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RefSeq; XP_005608679.1; XM_005608622.2.
STRING; 9796.ENSECAP00000013335; -.
PaxDb; F6U044; -.
Ensembl; ENSECAT00000016509; ENSECAP00000013335; ENSECAG00000015766.
GeneID; 100053270; -.
CTD; 6622; -.
eggNOG; ENOG410IWI2; Eukaryota.
eggNOG; ENOG4111TDZ; LUCA.
GeneTree; ENSGT00390000016161; -.
InParanoid; F6U044; -.
OMA; SEAYEMP; -.
OrthoDB; EOG091G11PA; -.
TreeFam; TF332776; -.
Proteomes; UP000002281; Chromosome 3.
Bgee; ENSECAG00000015766; -.
GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0016234; C:inclusion body; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:GOC.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0031092; C:platelet alpha granule membrane; IEA:Ensembl.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0099512; C:supramolecular fiber; IEA:Ensembl.
GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
GO; GO:0050544; F:arachidonic acid binding; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:1903136; F:cuprous ion binding; IEA:Ensembl.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
GO; GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO; GO:0042393; F:histone binding; IEA:Ensembl.
GO; GO:0030544; F:Hsp70 protein binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
GO; GO:0016491; F:oxidoreductase activity; IEA:Ensembl.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
GO; GO:0048156; F:tau protein binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO; GO:0071280; P:cellular response to copper ion; IEA:Ensembl.
GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO; GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO; GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO; GO:1904715; P:negative regulation of chaperone-mediated autophagy; IEA:Ensembl.
GO; GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl.
GO; GO:0035067; P:negative regulation of histone acetylation; IEA:Ensembl.
GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
GO; GO:0032769; P:negative regulation of monooxygenase activity; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0051622; P:negative regulation of norepinephrine uptake; IEA:Ensembl.
GO; GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0051612; P:negative regulation of serotonin uptake; IEA:Ensembl.
GO; GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IEA:Ensembl.
GO; GO:0032410; P:negative regulation of transporter activity; IEA:Ensembl.
GO; GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO; GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:1903284; P:positive regulation of glutathione peroxidase activity; IEA:Ensembl.
GO; GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IEA:Ensembl.
GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO; GO:0014059; P:regulation of dopamine secretion; IEA:Ensembl.
GO; GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO; GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO; GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO; GO:0010517; P:regulation of phospholipase activity; IEA:Ensembl.
GO; GO:1905606; P:regulation of presynapse assembly; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0034341; P:response to interferon-gamma; IEA:Ensembl.
GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
GO; GO:0010040; P:response to iron(II) ion; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0032026; P:response to magnesium ion; IEA:Ensembl.
GO; GO:0050808; P:synapse organization; IEA:Ensembl.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl.
InterPro; IPR001058; Synuclein.
InterPro; IPR002460; Synuclein_alpha.
PANTHER; PTHR13820; PTHR13820; 1.
PANTHER; PTHR13820:SF12; PTHR13820:SF12; 1.
Pfam; PF01387; Synuclein; 1.
PRINTS; PR01212; ASYNUCLEIN.
PRINTS; PR01211; SYNUCLEIN.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Reference proteome {ECO:0000313|Proteomes:UP000002281}.
SEQUENCE 140 AA; 14548 MW; 655856EA5958BEEF CRC64;
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK
EQVTNVGEAV VTGVTAVAQK TVEGAESIAA ATGFGKKDHL GKSEEGAAQE GILEDMPVDP
DNEAYEMPSE EGYQDYEPEA


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