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Alpha-synuclein

 G1M951_AILME            Unreviewed;       140 AA.
G1M951;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
13-FEB-2019, entry version 52.
RecName: Full=Alpha-synuclein {ECO:0000256|RuleBase:RU361225};
Name=SNCA {ECO:0000313|Ensembl:ENSAMEP00000015871};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
Ailuropoda.
NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015871, ECO:0000313|Proteomes:UP000008912};
[1] {ECO:0000313|Ensembl:ENSAMEP00000015871}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
Wang J., Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000015871}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the synuclein family.
{ECO:0000256|RuleBase:RU361225}.
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EMBL; ACTA01003888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01011888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01179879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01187877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01195875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_002917752.1; XM_002917706.3.
RefSeq; XP_002917753.1; XM_002917707.3.
RefSeq; XP_011221333.1; XM_011223031.2.
RefSeq; XP_019653586.1; XM_019798027.1.
RefSeq; XP_019653587.1; XM_019798028.1.
RefSeq; XP_019653588.1; XM_019798029.1.
ProteinModelPortal; G1M951; -.
SMR; G1M951; -.
STRING; 9646.ENSAMEP00000015871; -.
Ensembl; ENSAMET00000016531; ENSAMEP00000015871; ENSAMEG00000015065.
GeneID; 100478316; -.
KEGG; aml:100478316; -.
CTD; 6622; -.
eggNOG; ENOG410IWI2; Eukaryota.
eggNOG; ENOG4111TDZ; LUCA.
GeneTree; ENSGT00940000154211; -.
InParanoid; G1M951; -.
KO; K04528; -.
OMA; SEAYEMP; -.
OrthoDB; 1544450at2759; -.
TreeFam; TF332776; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
GO; GO:0005938; C:cell cortex; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0016234; C:inclusion body; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:GOC.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0031092; C:platelet alpha granule membrane; IEA:Ensembl.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0099512; C:supramolecular fiber; IEA:Ensembl.
GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:Ensembl.
GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
GO; GO:0050544; F:arachidonic acid binding; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:1903136; F:cuprous ion binding; IEA:Ensembl.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
GO; GO:0008198; F:ferrous iron binding; IEA:Ensembl.
GO; GO:0042393; F:histone binding; IEA:Ensembl.
GO; GO:0030544; F:Hsp70 protein binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
GO; GO:0016491; F:oxidoreductase activity; IEA:Ensembl.
GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
GO; GO:0051219; F:phosphoprotein binding; IEA:Ensembl.
GO; GO:0000149; F:SNARE binding; IEA:Ensembl.
GO; GO:0048156; F:tau protein binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
GO; GO:0071280; P:cellular response to copper ion; IEA:Ensembl.
GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
GO; GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO; GO:0006631; P:fatty acid metabolic process; IEA:Ensembl.
GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO; GO:0007006; P:mitochondrial membrane organization; IEA:Ensembl.
GO; GO:1904715; P:negative regulation of chaperone-mediated autophagy; IEA:Ensembl.
GO; GO:0051585; P:negative regulation of dopamine uptake involved in synaptic transmission; IEA:Ensembl.
GO; GO:0045920; P:negative regulation of exocytosis; IEA:Ensembl.
GO; GO:0035067; P:negative regulation of histone acetylation; IEA:Ensembl.
GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
GO; GO:0032769; P:negative regulation of monooxygenase activity; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0051622; P:negative regulation of norepinephrine uptake; IEA:Ensembl.
GO; GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0051612; P:negative regulation of serotonin uptake; IEA:Ensembl.
GO; GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IEA:Ensembl.
GO; GO:0032410; P:negative regulation of transporter activity; IEA:Ensembl.
GO; GO:0006638; P:neutral lipid metabolic process; IEA:Ensembl.
GO; GO:0006644; P:phospholipid metabolic process; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:0045921; P:positive regulation of exocytosis; IEA:Ensembl.
GO; GO:1903284; P:positive regulation of glutathione peroxidase activity; IEA:Ensembl.
GO; GO:1903285; P:positive regulation of hydrogen peroxide catabolic process; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0051262; P:protein tetramerization; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0050812; P:regulation of acyl-CoA biosynthetic process; IEA:Ensembl.
GO; GO:0014059; P:regulation of dopamine secretion; IEA:Ensembl.
GO; GO:0014048; P:regulation of glutamate secretion; IEA:Ensembl.
GO; GO:0040012; P:regulation of locomotion; IEA:Ensembl.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
GO; GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
GO; GO:0010517; P:regulation of phospholipase activity; IEA:Ensembl.
GO; GO:1905606; P:regulation of presynapse assembly; IEA:Ensembl.
GO; GO:0022898; P:regulation of transmembrane transporter activity; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0034341; P:response to interferon-gamma; IEA:Ensembl.
GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
GO; GO:0010040; P:response to iron(II) ion; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0032026; P:response to magnesium ion; IEA:Ensembl.
GO; GO:0035493; P:SNARE complex assembly; IEA:Ensembl.
GO; GO:0050808; P:synapse organization; IEA:Ensembl.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:Ensembl.
GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl.
GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl.
InterPro; IPR001058; Synuclein.
InterPro; IPR002460; Synuclein_alpha.
PANTHER; PTHR13820; PTHR13820; 1.
PANTHER; PTHR13820:SF5; PTHR13820:SF5; 1.
Pfam; PF01387; Synuclein; 1.
PRINTS; PR01212; ASYNUCLEIN.
PRINTS; PR01211; SYNUCLEIN.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000008912};
Reference proteome {ECO:0000313|Proteomes:UP000008912}.
SEQUENCE 140 AA; 14479 MW; 8E5BD0391458BD62 CRC64;
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK
EQVTNVGEAV VTGVTAVAQK TVEGAGSIAA ATGFGKKDQL GKSEEGGPQE GILEDMPVDP
DNEAYEMPSE EGYQDYEPEA


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