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Aluminum-activated malate transporter 1 (AtALMT1)

 ALMT1_ARATH             Reviewed;         493 AA.
Q9SJE9; A8VPV4; Q15EV0; Q15EV1; Q15EV2; Q15EV3; Q15EV4;
30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-JUN-2017, entry version 83.
RecName: Full=Aluminum-activated malate transporter 1;
Short=AtALMT1;
Name=ALMT1; OrderedLocusNames=At1g08430; ORFNames=T27G7.11;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY,
INDUCTION BY ALUMINUM, DISRUPTION PHENOTYPE, GENE FAMILY, AND
NOMENCLATURE.
STRAIN=cv. Bay-0, cv. Cvi-0, cv. Landsberg erecta, cv. Nd-0, and
cv. No-0;
PubMed=16740662; DOI=10.1073/pnas.0602868103;
Hoekenga O.A., Maron L.G., Pineros M.A., Cancado G.M., Shaff J.,
Kobayashi Y., Ryan P.R., Dong B., Delhaize E., Sasaki T.,
Matsumoto H., Yamamoto Y., Koyama H., Kochian L.V.;
"AtALMT1, which encodes a malate transporter, is identified as one of
several genes critical for aluminum tolerance in Arabidopsis.";
Proc. Natl. Acad. Sci. U.S.A. 103:9738-9743(2006).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION BY ALUMINUM AND
RHIZOTOXIC TREATMENTS, ENZYME REGULATION, DISRUPTION PHENOTYPE,
PHOSPHORYLATION, AND TISSUE SPECIFICITY.
STRAIN=cv. Col-4, and cv. Wa-1;
PubMed=17885092; DOI=10.1104/pp.107.102335;
Kobayashi Y., Hoekenga O.A., Ito H., Nakashima M., Saito S.,
Shaff J.E., Maron L.G., Pineros M.A., Kochian L.V., Koyama H.;
"Characterization of AtALMT1 expression in aluminum-inducible malate
release and its role for rhizotoxic stress tolerance in Arabidopsis.";
Plant Physiol. 145:843-852(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130712; DOI=10.1038/35048500;
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
"Sequence and analysis of chromosome 1 of the plant Arabidopsis
thaliana.";
Nature 408:816-820(2000).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[5]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=18826429; DOI=10.1111/j.1365-313X.2008.03696.x;
Liu J., Magalhaes J.V., Shaff J., Kochian L.V.;
"Aluminum-activated citrate and malate transporters from the MATE and
ALMT families function independently to confer Arabidopsis aluminum
tolerance.";
Plant J. 57:389-399(2009).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=19321711; DOI=10.1104/pp.108.134700;
Sawaki Y., Iuchi S., Kobayashi Y., Kobayashi Y., Ikka T., Sakurai N.,
Fujita M., Shinozaki K., Shibata D., Kobayashi M., Koyama H.;
"STOP1 regulates multiple genes that protect arabidopsis from proton
and aluminum toxicities.";
Plant Physiol. 150:281-294(2009).
-!- FUNCTION: Malate transporter critical for aluminum tolerance. The
STOP1 transcription factor is required for ALMT1 expression.
{ECO:0000269|PubMed:16740662, ECO:0000269|PubMed:17885092,
ECO:0000269|PubMed:18826429, ECO:0000269|PubMed:19321711}.
-!- ENZYME REGULATION: Activated by external aluminum.
{ECO:0000269|PubMed:17885092}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in roots, but not in shoots.
Detected in the root apex in absence of aluminum stress and in
root apices, the stele and endodermis of the elongating zone of
primary and lateral roots after aluminum stress. Not expressed in
cortical and epidermal cells. {ECO:0000269|PubMed:16740662,
ECO:0000269|PubMed:17885092}.
-!- INDUCTION: Up-regulated by aluminum. Small induction by erbium
(Er) and low pH stress, but no induction by cadmium, copper,
lanthanum or sodium. {ECO:0000269|PubMed:16740662,
ECO:0000269|PubMed:17885092}.
-!- PTM: Phosphorylated. A reversible phosphorylation is required for
activation (By similarity). {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: No visible phenotype when grown under normal
conditions. Lack of aluminum-activated malate release and shorter
roots when submitted to aluminum stress.
{ECO:0000269|PubMed:16740662, ECO:0000269|PubMed:17885092,
ECO:0000269|PubMed:18826429, ECO:0000269|PubMed:19321711}.
-!- MISCELLANEOUS: Essential factor for aluminum (Al) tolerance but
does not represent the major Al tolerance QTL also found on
chromosome 1. Acts in parallel but independently of MATE, an
aluminum-activated root citrate transporter.
-!- MISCELLANEOUS: A reversible phosphorylation acting both at the
transcriptional and post-transcriptional levels is required to
activate malate release in response to aluminum.
-!- SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; DQ465038; ABF22742.1; -; Genomic_DNA.
EMBL; DQ465039; ABF22743.1; -; Genomic_DNA.
EMBL; DQ465040; ABF22744.1; -; Genomic_DNA.
EMBL; DQ465041; ABF22745.1; -; Genomic_DNA.
EMBL; DQ465042; ABF22746.1; -; Genomic_DNA.
EMBL; AC006932; AAF22890.1; -; Genomic_DNA.
EMBL; CP002684; AEE28289.1; -; Genomic_DNA.
EMBL; EU181365; ABW33503.1; -; mRNA.
RefSeq; NP_172319.1; NM_100716.5.
UniGene; At.42261; -.
SMR; Q9SJE9; -.
BioGrid; 22604; 28.
IntAct; Q9SJE9; 1.
STRING; 3702.AT1G08430.1; -.
TCDB; 2.A.85.2.3; the aromatic acid exporter (arae) family.
PaxDb; Q9SJE9; -.
EnsemblPlants; AT1G08430.1; AT1G08430.1; AT1G08430.
GeneID; 837363; -.
Gramene; AT1G08430.1; AT1G08430.1; AT1G08430.
KEGG; ath:AT1G08430; -.
Araport; AT1G08430; -.
TAIR; locus:2201781; AT1G08430.
eggNOG; KOG4711; Eukaryota.
eggNOG; ENOG410XR8V; LUCA.
InParanoid; Q9SJE9; -.
OMA; EYFEART; -.
OrthoDB; EOG09360D95; -.
PhylomeDB; Q9SJE9; -.
PRO; PR:Q9SJE9; -.
Proteomes; UP000006548; Chromosome 1.
Genevisible; Q9SJE9; AT.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0015140; F:malate transmembrane transporter activity; IDA:TAIR.
GO; GO:0071423; P:malate transmembrane transport; IMP:TAIR.
GO; GO:0044148; P:positive regulation of growth of symbiont involved in interaction with host; IMP:TAIR.
GO; GO:0010044; P:response to aluminum ion; IMP:TAIR.
InterPro; IPR020966; ALMT.
Pfam; PF11744; ALMT; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Ion channel; Ion transport;
Membrane; Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 493 Aluminum-activated malate transporter 1.
/FTId=PRO_0000401460.
TRANSMEM 28 48 Helical. {ECO:0000255}.
TRANSMEM 51 71 Helical. {ECO:0000255}.
TRANSMEM 104 124 Helical. {ECO:0000255}.
TRANSMEM 133 153 Helical. {ECO:0000255}.
TRANSMEM 169 189 Helical. {ECO:0000255}.
COMPBIAS 62 65 Poly-Val.
COMPBIAS 314 352 Ser-rich.
MOD_RES 320 320 Phosphoserine. {ECO:0000255}.
MOD_RES 327 327 Phosphoserine. {ECO:0000255}.
MOD_RES 385 385 Phosphothreonine. {ECO:0000255}.
VARIANT 33 36 VLVS -> GLVA (in strain: cv. Nd-0, cv.
No-0).
VARIANT 36 36 S -> A (in strain: cv. Bay-0, cv.
Landsberg erecta).
VARIANT 77 493 Missing (in strain: cv. Wa-1; induces
hypersensitivity to aluminum stress).
VARIANT 194 194 S -> F (in strain: cv. Bay-0).
VARIANT 257 257 P -> S (in strain: cv. Landsberg erecta).
VARIANT 298 298 I -> V (in strain: cv. Bay-0, cv. Cvi-0,
cv. Landsberg erecta, cv. Nd-0, cv. No-
0).
VARIANT 375 375 V -> I (in strain: cv. Cvi-0).
SEQUENCE 493 AA; 55077 MW; CAEBF439C3E5CEC6 CRC64;
MEKVREIVRE GIRVGNEDPR RIIHAFKVGL ALVLVSSFYY YQPFGPFTDY FGINAMWAVM
TVVVVFEFSV GATLGKGLNR GVATLVAGGL GIGAHQLARL SGATVEPILL VMLVFVQAAL
STFVRFFPWV KTKFDYGILI FILTFALISL SGFRDEEIMD LAESRLSTVV IGGVSCILIS
IFVCPVWAGQ DLHSLLASNF DTLSHFLQDF GDEYFEAREK GDYKVVEKRK KNLERYKSVL
DSKSDEEALA NYAEWEPPHG QFRFRHPWKQ YVAVGALLRQ CAYRIDALNS YINSDFQIPV
DIKKKLETPL RRMSSESGNS MKEMSISLKQ MIKSSSSDIH VSNSQAACKS LSTLLKSGIL
NDVEPLQMIS LMTTVSMLID IVNLTEKISE SVHELASAAR FKNKMRPTVL YEKSDSGSIG
RAMPIDSHED HHVVTVLHDV DNDRSNNVDD SRGGSSQDSC HHVAIKIVDD NSNHEKHEDG
EIHVHTLSNG HLQ


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