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Amiloride-sensitive sodium channel subunit gamma (Epithelial Na( ) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
SCNNG_HUMAN Reviewed; 649 AA.
P51170; P78437; Q6PCC2; Q93023; Q93024; Q93025; Q93026; Q93027;
Q96TD2;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
30-MAY-2006, sequence version 4.
28-MAR-2018, entry version 177.
RecName: Full=Amiloride-sensitive sodium channel subunit gamma;
AltName: Full=Epithelial Na(+) channel subunit gamma;
Short=ENaCG;
Short=Gamma-ENaC;
AltName: Full=Gamma-NaCH;
AltName: Full=Nonvoltage-gated sodium channel 1 subunit gamma;
AltName: Full=SCNEG;
Name=SCNN1G;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, AND SUBCELLULAR
LOCATION.
TISSUE=Lung;
PubMed=7490094; DOI=10.1006/geno.1995.1188;
Voilley N., Bassilana F., Mignon C., Merscher S., Mattei M.-G.,
Carle G.F., Lazdunski M., Barbry P.;
"Cloning, chromosomal localization, and physical linkage of the beta
and gamma subunits (SCNN1B and SCNN1G) of the human epithelial
amiloride-sensitive sodium channel.";
Genomics 28:560-565(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], VARIANTS TRP-178; PRO-502 AND SER-614, AND
SUBUNIT.
TISSUE=Kidney;
PubMed=7762608;
McDonald F.J., Snyder P.M., Price M.P., Welsh M.J.;
"Cloning and expression of the beta- and gamma-subunits of the human
epithelial sodium channel.";
Am. J. Physiol. 268:C1157-C1163(1995).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PRO-502.
PubMed=12107247; DOI=10.1210/jc.87.7.3344;
Saxena A., Hanukoglu I., Saxena D., Thompson R.J., Gardiner R.M.,
Hanukoglu A.;
"Novel mutations responsible for autosomal recessive multisystem
pseudohypoaldosteronism and sequence variants in epithelial sodium
channel alpha-, beta-, and gamma-subunit genes.";
J. Clin. Endocrinol. Metab. 87:3344-3350(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-105; 218-269; 306-392;
433-463 AND 499-515, AND VARIANT PRO-502.
PubMed=8824247; DOI=10.1074/jbc.271.42.26062;
Thomas C.P., Doggett N.A., Fisher R., Stokes J.B.;
"Genomic organization and the 5' flanking region of the gamma subunit
of the human amiloride-sensitive epithelial sodium channel.";
J. Biol. Chem. 271:26062-26066(1996).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 524-649, AND INVOLVEMENT IN
LIDLS.
PubMed=7550319; DOI=10.1038/ng0995-76;
Hansson J.H., Nelson-Williams C., Suzuki H., Schild L., Shimkets R.A.,
Lu Y., Canessa C.M., Iwasaki T., Rossier B.C., Lifton R.P.;
"Hypertension caused by a truncated epithelial sodium channel gamma
subunit: genetic heterogeneity of Liddle syndrome.";
Nat. Genet. 11:76-82(1995).
[7]
INTERACTION WITH WWP1 AND WWP2.
PubMed=9169421; DOI=10.1074/jbc.272.23.14611;
Pirozzi G., McConnell S.J., Uveges A.J., Carter J.M., Sparks A.B.,
Kay B.K., Fowlkes D.M.;
"Identification of novel human WW domain-containing proteins by
cloning of ligand targets.";
J. Biol. Chem. 272:14611-14616(1997).
[8]
INTERACTION WITH NEDD4 AND NEDD4L.
PubMed=11244092; DOI=10.1074/jbc.C000906200;
Harvey K.F., Dinudom A., Cook D.I., Kumar S.;
"The Nedd4-like protein KIAA0439 is a potential regulator of the
epithelial sodium channel.";
J. Biol. Chem. 276:8597-8601(2001).
[9]
INTERACTION WITH NEDD4 AND WWP2.
PubMed=12167593; DOI=10.1152/ajprenal.00080.2002;
McDonald F.J., Western A.H., McNeil J.D., Thomas B.C., Olson D.R.,
Snyder P.M.;
"Ubiquitin-protein ligase WWP2 binds to and downregulates the
epithelial Na(+) channel.";
Am. J. Physiol. 283:F431-F436(2002).
[10]
PROTEOLYTIC PROCESSING.
PubMed=18650438; DOI=10.1074/jbc.M803931200;
Carattino M.D., Hughey R.P., Kleyman T.R.;
"Proteolytic processing of the epithelial sodium channel gamma subunit
has a dominant role in channel activation.";
J. Biol. Chem. 283:25290-25295(2008).
[11]
INVOLVEMENT IN BESC3.
PubMed=19017867; DOI=10.1378/chest.08-2246;
Mutesa L., Azad A.K., Verhaeghe C., Segers K., Vanbellinghen J.F.,
Ngendahayo L., Rusingiza E.K., Mutwa P.R., Rulisa S., Koulischer L.,
Cassiman J.J., Cuppens H., Bours V.;
"Genetic analysis of Rwandan patients with cystic fibrosis-like
symptoms: identification of novel cystic fibrosis transmembrane
conductance regulator and epithelial sodium channel gene variants.";
Chest 135:1233-1242(2009).
[12]
TISSUE SPECIFICITY.
PubMed=22207244; DOI=10.1007/s00418-011-0904-1;
Enuka Y., Hanukoglu I., Edelheit O., Vaknine H., Hanukoglu A.;
"Epithelial sodium channels (ENaC) are uniformly distributed on motile
cilia in the oviduct and the respiratory airways.";
Histochem. Cell Biol. 137:339-353(2012).
[13]
INTERACTION WITH PCSK9.
PubMed=22493497; DOI=10.1074/jbc.M112.363382;
Sharotri V., Collier D.M., Olson D.R., Zhou R., Snyder P.M.;
"Regulation of epithelial sodium channel trafficking by proprotein
convertase subtilisin/kexin type 9 (PCSK9).";
J. Biol. Chem. 287:19266-19274(2012).
[14]
PROTEOLYTIC PROCESSING, FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
PubMed=24124190; DOI=10.1152/ajplung.00103.2013;
Hobbs C.A., Blanchard M.G., Alijevic O., Tan C.D., Kellenberger S.,
Bencharit S., Cao R., Kesimer M., Walton W.G., Henderson A.G.,
Redinbo M.R., Stutts M.J., Tarran R.;
"Identification of the SPLUNC1 ENaC-inhibitory domain yields novel
strategies to treat sodium hyperabsorption in cystic fibrosis airway
epithelial cultures.";
Am. J. Physiol. 305:L990-L1001(2013).
[15]
REVIEW.
PubMed=23547933;
Alvarez de la Rosa D., Navarro-Gonzalez J.F., Giraldez T.;
"ENaC modulators and renal disease.";
Curr. Mol. Pharmacol. 6:35-43(2013).
[16]
PHYLOGENETIC ANALYSIS, AND NOMENCLATURE.
PubMed=26772908; DOI=10.1016/j.gene.2015.12.061;
Hanukoglu I., Hanukoglu A.;
"Epithelial sodium channel (ENaC) family: Phylogeny, structure-
function, tissue distribution, and associated inherited diseases.";
Gene 579:95-132(2016).
[17]
VARIANTS TRP-178; PRO-502 AND SER-614.
PubMed=10404817; DOI=10.1210/jcem.84.7.5857;
Arai K., Zachman K., Shibasaki T., Chrousos G.P.;
"Polymorphisms of amiloride-sensitive sodium channel subunits in five
sporadic cases of pseudohypoaldosteronism: do they have pathologic
potential?";
J. Clin. Endocrinol. Metab. 84:2434-2437(1999).
[18]
VARIANTS CYS-49 AND SER-183.
PubMed=10391210; DOI=10.1038/10297;
Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A.,
Cooper R., Lipshutz R., Chakravarti A.;
"Patterns of single-nucleotide polymorphisms in candidate genes for
blood-pressure homeostasis.";
Nat. Genet. 22:239-247(1999).
[19]
VARIANT [LARGE SCALE ANALYSIS] ARG-58.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
[20]
VARIANTS SER-183 AND LYS-197, AND INVOLVEMENT IN BESC3.
PubMed=18507830; DOI=10.1186/1465-9921-9-46;
Fajac I., Viel M., Sublemontier S., Hubert D., Bienvenu T.;
"Could a defective epithelial sodium channel lead to bronchiectasis.";
Respir. Res. 9:46-46(2008).
-!- FUNCTION: Sodium permeable non-voltage-sensitive ion channel
inhibited by the diuretic amiloride. Mediates the electrodiffusion
of the luminal sodium (and water, which follows osmotically)
through the apical membrane of epithelial cells. Plays an
essential role in electrolyte and blood pressure homeostasis, but
also in airway surface liquid homeostasis, which is important for
proper clearance of mucus. Controls the reabsorption of sodium in
kidney, colon, lung and sweat glands. Also plays a role in taste
perception. {ECO:0000269|PubMed:24124190,
ECO:0000303|PubMed:7490094}.
-!- ENZYME REGULATION: Activated by WNK1, WNK2, WNK3 and WNK4.
{ECO:0000250|UniProtKB:Q9WU39}.
-!- SUBUNIT: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B
and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit
exists only in some organisms and can replace the alpha/SCNN1A
subunit to form an alternative channel with specific properties
(PubMed:7762608). Interacts with NEDD4; via the WW domains
(PubMed:11244092, PubMed:12167593). Interacts with NEDD4L; via the
WW domains (PubMed:11244092). Interacts with WWP1; via the WW
domains (PubMed:9169421). Interacts with WWP2; via the WW domains
(PubMed:9169421, PubMed:12167593). Interacts with the full-length
immature form of PCSK9 (pro-PCSK9) (PubMed:22493497).
{ECO:0000269|PubMed:11244092, ECO:0000269|PubMed:12167593,
ECO:0000269|PubMed:22493497, ECO:0000269|PubMed:24124190,
ECO:0000269|PubMed:7490094, ECO:0000269|PubMed:7762608,
ECO:0000269|PubMed:9169421}.
-!- INTERACTION:
P37088:SCNN1A; NbExp=3; IntAct=EBI-2547354, EBI-7845444;
-!- SUBCELLULAR LOCATION: Apical cell membrane
{ECO:0000269|PubMed:24124190, ECO:0000303|PubMed:7490094}; Multi-
pass membrane protein {ECO:0000250|UniProtKB:P37089}. Note=Apical
membrane of epithelial cells. {ECO:0000303|PubMed:7490094}.
-!- TISSUE SPECIFICITY: Expressed in kidney (at protein level).
{ECO:0000269|PubMed:22207244}.
-!- PTM: Phosphorylated on serine and threonine residues. Aldosterone
and insulin increase the basal level of phosphorylation.
{ECO:0000250|UniProtKB:P37091}.
-!- PTM: Ubiquitinated; this targets individual subunits for
endocytosis and proteasome-mediated degradation.
{ECO:0000250|UniProtKB:P37091}.
-!- PTM: ENaC cleavage by furin, and subsequently by prostasin
(PRSS8), leads to a stepwise increase in the open probability of
the channel as a result of release of the alpha and gamma subunit
inhibitory tracts, respectively. Interaction of ENaC subunit
SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
{ECO:0000269|PubMed:18650438, ECO:0000269|PubMed:24124190}.
-!- DISEASE: Liddle syndrome (LIDLS) [MIM:177200]: An autosomal
dominant disorder characterized by hypertension, hypokalemic
alkalosis, and suppression of plasma renin activity and
aldosterone secretion. {ECO:0000269|PubMed:7550319}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- DISEASE: Bronchiectasis with or without elevated sweat chloride 3
(BESC3) [MIM:613071]: A debilitating respiratory disease
characterized by chronic, abnormal dilatation of the bronchi and
other cystic fibrosis-like symptoms in the absence of known causes
of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary
dyskinesia, common variable immunodeficiency, foreign body
obstruction). Clinical features include sub-normal lung function,
sinopulmonary infections, chronic productive cough, excessive
sputum production, and elevated sweat chloride in some cases.
{ECO:0000269|PubMed:18507830, ECO:0000269|PubMed:19017867}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
1.A.6) family. SCNN1G subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X87160; CAA60633.1; -; mRNA.
EMBL; L36592; AAA75460.1; -; mRNA.
EMBL; AF356502; AAK50910.1; -; Genomic_DNA.
EMBL; AF356493; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356494; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356495; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356496; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356497; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356498; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356499; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356500; AAK50910.1; JOINED; Genomic_DNA.
EMBL; AF356501; AAK50910.1; JOINED; Genomic_DNA.
EMBL; BC059391; AAH59391.1; -; mRNA.
EMBL; BC069652; AAH69652.1; -; mRNA.
EMBL; U48936; AAC50737.1; -; mRNA.
EMBL; U53836; AAC50744.1; -; Genomic_DNA.
EMBL; U53837; AAC50745.1; -; Genomic_DNA.
EMBL; U53841; AAC50749.1; -; Genomic_DNA.
EMBL; U53844; AAC50752.1; -; Genomic_DNA.
EMBL; U53845; AAC50753.1; -; Genomic_DNA.
EMBL; U53846; AAC50754.1; -; Genomic_DNA.
EMBL; U53847; AAC50755.1; -; Genomic_DNA.
EMBL; U53850; AAC50758.1; -; Genomic_DNA.
EMBL; U53852; AAC50760.1; -; Genomic_DNA.
EMBL; U35630; AAC50217.1; -; Genomic_DNA.
CCDS; CCDS10608.1; -.
PIR; I38204; I38204.
PIR; I64847; I64847.
RefSeq; NP_001030.2; NM_001039.3.
UniGene; Hs.371727; -.
ProteinModelPortal; P51170; -.
BioGrid; 112244; 13.
CORUM; P51170; -.
ELM; P51170; -.
IntAct; P51170; 4.
MINT; P51170; -.
STRING; 9606.ENSP00000300061; -.
ChEMBL; CHEMBL2107836; -.
DrugBank; DB00594; Amiloride.
DrugBank; DB00384; Triamterene.
GuidetoPHARMACOLOGY; 741; -.
TCDB; 1.A.6.1.1; the epithelial na(+) channel (enac) family.
iPTMnet; P51170; -.
PhosphoSitePlus; P51170; -.
BioMuta; SCNN1G; -.
DMDM; 108885072; -.
PaxDb; P51170; -.
PeptideAtlas; P51170; -.
PRIDE; P51170; -.
Ensembl; ENST00000300061; ENSP00000300061; ENSG00000166828.
GeneID; 6340; -.
KEGG; hsa:6340; -.
UCSC; uc002dlm.2; human.
CTD; 6340; -.
DisGeNET; 6340; -.
EuPathDB; HostDB:ENSG00000166828.2; -.
GeneCards; SCNN1G; -.
HGNC; HGNC:10602; SCNN1G.
HPA; HPA071194; -.
MalaCards; SCNN1G; -.
MIM; 177200; phenotype.
MIM; 600761; gene.
MIM; 613071; phenotype.
neXtProt; NX_P51170; -.
OpenTargets; ENSG00000166828; -.
Orphanet; 171876; Generalized pseudohypoaldosteronism type 1.
Orphanet; 60033; Idiopathic bronchiectasis.
Orphanet; 526; Liddle syndrome.
PharmGKB; PA307; -.
eggNOG; KOG4294; Eukaryota.
eggNOG; ENOG410ZNFK; LUCA.
GeneTree; ENSGT00760000119120; -.
HOVERGEN; HBG058435; -.
InParanoid; P51170; -.
KO; K04827; -.
OMA; NWMYCYY; -.
OrthoDB; EOG091G0KW6; -.
PhylomeDB; P51170; -.
TreeFam; TF330663; -.
Reactome; R-HSA-2672351; Stimuli-sensing channels.
SIGNOR; P51170; -.
GeneWiki; SCNN1G; -.
GenomeRNAi; 6340; -.
PRO; PR:P51170; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000166828; -.
ExpressionAtlas; P51170; baseline and differential.
Genevisible; P51170; HS.
GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0034706; C:sodium channel complex; IDA:UniProtKB.
GO; GO:0005216; F:ion channel activity; IMP:CACAO.
GO; GO:0015280; F:ligand-gated sodium channel activity; TAS:ProtInc.
GO; GO:0005272; F:sodium channel activity; TAS:ProtInc.
GO; GO:0050699; F:WW domain binding; IPI:BHF-UCL.
GO; GO:0007588; P:excretion; TAS:ProtInc.
GO; GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO; GO:0050891; P:multicellular organismal water homeostasis; IDA:UniProtKB.
GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
GO; GO:0055078; P:sodium ion homeostasis; IDA:UniProtKB.
GO; GO:0035725; P:sodium ion transmembrane transport; IDA:UniProtKB.
GO; GO:0006814; P:sodium ion transport; TAS:ProtInc.
InterPro; IPR001873; ENaC.
InterPro; IPR004724; ENaC_chordates.
InterPro; IPR020903; ENaC_CS.
PANTHER; PTHR11690; PTHR11690; 1.
Pfam; PF00858; ASC; 1.
PRINTS; PR01078; AMINACHANNEL.
TIGRFAMs; TIGR00859; ENaC; 1.
PROSITE; PS01206; ASC; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Membrane; Phosphoprotein; Polymorphism;
Reference proteome; Sensory transduction; Sodium; Sodium channel;
Sodium transport; Taste; Transmembrane; Transmembrane helix;
Transport; Ubl conjugation.
CHAIN 1 649 Amiloride-sensitive sodium channel
subunit gamma.
/FTId=PRO_0000181276.
TOPO_DOM 1 55 Cytoplasmic.
{ECO:0000250|UniProtKB:P37089}.
TRANSMEM 56 76 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 77 541 Extracellular.
{ECO:0000250|UniProtKB:P37089}.
TRANSMEM 542 562 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 563 649 Cytoplasmic.
{ECO:0000250|UniProtKB:P37089}.
CARBOHYD 209 209 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 497 497 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 49 49 G -> C (in dbSNP:rs5733).
{ECO:0000269|PubMed:10391210}.
/FTId=VAR_014893.
VARIANT 58 58 G -> R (in a colorectal cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036483.
VARIANT 178 178 R -> W. {ECO:0000269|PubMed:10404817,
ECO:0000269|PubMed:7762608}.
/FTId=VAR_015842.
VARIANT 183 183 G -> S (in a patient with bronchiectasis;
dbSNP:rs5736).
{ECO:0000269|PubMed:10391210,
ECO:0000269|PubMed:18507830}.
/FTId=VAR_014894.
VARIANT 197 197 E -> K (in a patient with bronchiectasis;
dbSNP:rs5738).
{ECO:0000269|PubMed:18507830}.
/FTId=VAR_034485.
VARIANT 502 502 A -> P. {ECO:0000269|PubMed:10404817,
ECO:0000269|PubMed:12107247,
ECO:0000269|PubMed:7762608,
ECO:0000269|PubMed:8824247}.
/FTId=VAR_015843.
VARIANT 614 614 A -> S. {ECO:0000269|PubMed:10404817,
ECO:0000269|PubMed:7762608}.
/FTId=VAR_015844.
CONFLICT 339 339 F -> S (in Ref. 1; CAA60633).
{ECO:0000305}.
CONFLICT 350 350 A -> T (in Ref. 1; CAA60633).
{ECO:0000305}.
CONFLICT 369 369 Y -> S (in Ref. 1; CAA60633).
{ECO:0000305}.
CONFLICT 375 375 D -> G (in Ref. 1; CAA60633).
{ECO:0000305}.
CONFLICT 458 458 S -> R (in Ref. 1; CAA60633).
{ECO:0000305}.
CONFLICT 461 463 EWT -> DGH (in Ref. 5; AAC50758).
{ECO:0000305}.
SEQUENCE 649 AA; 74270 MW; F67ED45F03A9BF3F CRC64;
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR LRRLLWIGFT
LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC NINPYKYSTV RHLLADLEQE
TREALKSLYG FPESRKRREA ESWNSVSEGK QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR
KVGGSIIHKA SNVMHIESKQ VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ
VPLEKKINMS YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG
GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA MVTSIGMHLT
ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ TKMVEKCGCA QYSQPLPPAA
NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL
LPVLTWDQGR QVNKKLNKTD LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS
CSVVCVIEII EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD
DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL
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ГЕНТАУЪР БЪЛГАРИЯ
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Pathways :
WP2292: Chemokine signaling pathway
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP152: FGF signaling pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP1722: Th1/Th2
WP1836: Interferon gamma signaling
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP1993: angiogenesis overview
WP2006: Squamous cell TarBase
WP2152: BDNF
WP2199: Seed Development
WP262: EBV LMP1 signaling
WP32: Translation Factors
WP537: Translation Factors
WP542: Electron Transport Chain
WP758: EBV LMP1 signaling
WP760: estrogen signalling
WP866: EBV LMP1 signaling
WP868: estrogen signalling
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1644: DNA replication
Related Genes :
[Asic2 Accn1 Bnac1 Mdeg] Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive brain sodium channel 2) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)
[ASIC2 ACCN ACCN1 BNAC1 MDEG] Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Amiloride-sensitive cation channel neuronal 1) (Brain sodium channel 1) (BNC1) (BNaC1) (Mammalian degenerin homolog) (MDEG)
[ASIC3 ACCN3 SLNAC1 TNAC1] Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1)
[Asic2 Accn1 Bnac1] Acid-sensing ion channel 2 (ASIC2) (Amiloride-sensitive brain sodium channel) (Amiloride-sensitive cation channel 1, neuronal) (Brain sodium channel 1) (BNC1) (BNaC1)
[SCNN1A SCNN1] Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
[AOC1 ABP1 DAO1] Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO)
[AOC1 ABP1] Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase)
[Scnn1a Renac] Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
[Aoc1 Abp1] Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase)
[SCNN1B] Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
[Scnn1g] Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
[SCNN1G] Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
[Aoc1 Abp1] Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase)
[SCNN1D DNACH] Amiloride-sensitive sodium channel subunit delta (Delta-NaCH) (Epithelial Na(+) channel subunit delta) (Delta-ENaC) (ENaCD) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED)
[Scnn1b] Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
[Scnn1g] Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
[Scnn1a] Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
[Scnn1b] Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
[Asic1 Accn2 Bnac2] Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)
[Asic3 Accn3 Drasic] Acid-sensing ion channel 3 (ASIC3) (Amiloride-sensitive cation channel 3) (Dorsal root ASIC) (DRASIC)
[ASIC4 ACCN4] Acid-sensing ion channel 4 (ASIC4) (Amiloride-sensitive cation channel 4) (Amiloride-sensitive cation channel 4, pituitary)
[ASIC1 ACCN2 BNAC2] Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)
[ASIC1 ACCN2] Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal)
[Asic1 Accn2 Asic Bnac2] Acid-sensing ion channel 1 (ASIC1) (Acid-sensing ion channel) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)
[Asic3 Accn3 Drasic] Acid-sensing ion channel 3 (ASIC3) (Amiloride-sensitive cation channel 3) (Dorsal root ASIC) (DRASIC)
[asic1a accn2b] Acid-sensing ion channel 1A (ASIC1-A) (Acid-sensing ion channel 1.2-A) (Amiloride-sensitive cation channel 2-B, neuronal-A) (ZASIC1.2)
[Asic5 Accn5 Blinac] Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Brain-liver-intestine amiloride-sensitive Na(+) channel) (BLINaC)
[asic1c accn2c] Acid-sensing ion channel 1C (ASIC1-C) (Acid-sensing ion channel 1.3-C) (Amiloride-sensitive cation channel 2-C, neuronal-C) (ZASIC1.3)
[SCNN1A ENAC] Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
[SLC9A1 APNH1 NHE1] Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)
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