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Aminoglycoside 3'-phosphotransferase (EC 2.7.1.95) (APH(3')VIII) (Kanamycin kinase, type VIII) (Neomycin-kanamycin phosphotransferase type VIII)

 KKA8_ECOLX              Reviewed;         271 AA.
P14509;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
23-MAY-2018, entry version 67.
RecName: Full=Aminoglycoside 3'-phosphotransferase;
EC=2.7.1.95;
AltName: Full=APH(3')VIII;
AltName: Full=Kanamycin kinase, type VIII;
AltName: Full=Neomycin-kanamycin phosphotransferase type VIII;
Name=aphA;
Escherichia coli.
Plasmid IncP-alpha RP4.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=562;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2832861; DOI=10.1016/0147-619X(87)90062-X;
Pansegrau W., Miele L., Lurz R., Lanka E.;
"Nucleotide sequence of the kanamycin resistance determinant of
plasmid RP4: homology to other aminoglycoside 3'-
phosphotransferases.";
Plasmid 18:193-204(1987).
-!- FUNCTION: Resistance to kanamycin and structurally-related
aminoglycosides, including amikacin.
-!- CATALYTIC ACTIVITY: ATP + kanamycin = ADP + kanamycin 3'-
phosphate.
-!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase
family. {ECO:0000305}.
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EMBL; M20305; AAA26412.1; -; Genomic_DNA.
PIR; JU0103; JU0103.
ProteinModelPortal; P14509; -.
SMR; P14509; -.
IntAct; P14509; 1.
PRIDE; P14509; -.
KEGG; ag:AAA26412; -.
KO; K19272; -.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008910; F:kanamycin kinase activity; IEA:UniProtKB-EC.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
CDD; cd05150; APH; 1.
InterPro; IPR002575; Aminoglycoside_PTrfase.
InterPro; IPR024165; Kan/Strep_kinase.
InterPro; IPR011009; Kinase-like_dom_sf.
Pfam; PF01636; APH; 1.
PIRSF; PIRSF000706; Kanamycin_kin; 1.
SUPFAM; SSF56112; SSF56112; 1.
3: Inferred from homology;
Antibiotic resistance; ATP-binding; Kinase; Nucleotide-binding;
Plasmid; Transferase.
CHAIN 1 271 Aminoglycoside 3'-phosphotransferase.
/FTId=PRO_0000204811.
ACT_SITE 198 198 Proton acceptor. {ECO:0000250}.
SEQUENCE 271 AA; 30105 MW; A489F64B00E8F313 CRC64;
MNDIDREEPC AAAAVPESMA AHVMGYKWAR DKVGQSGCAV YRLHSKSGGS DLFLKHGKDA
FADDVTDEMV RLRWLAGHIS VPSVVSFVRT PNQAWLLTTA IHGKTAYQVL KSDFGARLVV
VDALAAFMRR LHAIPVSECS VQQWTTHAGL PERGSIEAGV VDVDDFDKER EGWTAEQVWE
AMHRLLPLAP DPVVTHGDFS LDNLLIVEGK VVGCIDVGRA GIADRYQDLA VLWNCLEEFE
PSLQERLVAQ YGIADPDRRK LQFHLLLDEL F


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