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Ammonium transporter 1

 AMT1_DICDI              Reviewed;         463 AA.
Q9BLG4; Q54ZJ7;
03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
23-MAY-2018, entry version 101.
RecName: Full=Ammonium transporter 1;
Name=amtA; ORFNames=DDB_G0277503;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
Dictyosteliaceae; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=AX2;
Chen Y., Huang C.-H.;
"Cloning and characterization of three ammonium transporter genes in
AX2 strain of Dictyostelium discoideum.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=AX4;
PubMed=17951519; DOI=10.1128/EC.00204-07;
Yoshino R., Morio T., Yamada Y., Kuwayama H., Sameshima M., Tanaka Y.,
Sesaki H., Iijima M.;
"Regulation of ammonia homeostasis by the ammonium transporter AmtA in
Dictyostelium discoideum.";
Eukaryot. Cell 6:2419-2428(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=12097910; DOI=10.1038/nature00847;
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A.,
Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G.,
Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A.,
Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[5]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=14686953; DOI=10.1111/j.1432-0436.2003.07109002.x;
Follstaedt S.C., Kirsten J.H., Singleton C.K.;
"Temporal and spatial expression of ammonium transporter genes during
growth and development of Dictyostelium discoideum.";
Differentiation 71:557-566(2003).
[6]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=16835443; DOI=10.1128/EC.00058-06;
Singleton C.K., Kirsten J.H., Dinsmore C.J.;
"Function of ammonium transporter A in the initiation of culmination
of development in Dictyostelium discoideum.";
Eukaryot. Cell 5:991-996(2006).
[7]
SUBCELLULAR LOCATION, AND TOPOLOGY.
PubMed=19108721; DOI=10.1186/1471-2121-9-71;
Kirsten J.H., Xiong Y., Davis C.T., Singleton C.K.;
"Subcellular localization of ammonium transporters in Dictyostelium
discoideum.";
BMC Cell Biol. 9:71-71(2008).
-!- FUNCTION: Ammonium transporter that mediates the excretion of
ammonium. Controls ammonium homeostasis during growth and
development. Ammonium has been shown to function as a morphogen at
multiple steps during the development.
{ECO:0000269|PubMed:14686953, ECO:0000269|PubMed:16835443,
ECO:0000269|PubMed:17951519}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19108721};
Multi-pass membrane protein {ECO:0000269|PubMed:19108721}.
Endosome membrane {ECO:0000269|PubMed:19108721}; Multi-pass
membrane protein {ECO:0000269|PubMed:19108721}. Lysosome membrane
{ECO:0000269|PubMed:19108721}; Multi-pass membrane protein
{ECO:0000269|PubMed:19108721}. Cytoplasmic vesicle, phagosome
membrane {ECO:0000269|PubMed:19108721}; Multi-pass membrane
protein {ECO:0000269|PubMed:19108721}.
-!- DEVELOPMENTAL STAGE: Predominantly found in the prestalk of the
slug. {ECO:0000269|PubMed:14686953}.
-!- DISRUPTION PHENOTYPE: Shortens transitional period (when fingers
and migrating slugs assess their environment to determine the
appropriateness of that environment for culmination and fruiting
body formation) of 1 to 2 hours and rarely forms slugs under
standard conditions of development. Gives a slightly enhanced
growth rate in axenic cultures. {ECO:0000269|PubMed:16835443}.
-!- SIMILARITY: Belongs to the ammonia transporter channel (TC
1.A.11.2) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF510716; AAP47145.1; -; mRNA.
EMBL; AB049067; BAB39709.1; -; Genomic_DNA.
EMBL; AAFI02000020; EAL68714.1; -; Genomic_DNA.
RefSeq; XP_642645.1; XM_637553.1.
ProteinModelPortal; Q9BLG4; -.
STRING; 44689.DDB0185017; -.
TCDB; 1.A.11.1.7; the ammonium transporter channel (amt) family.
PaxDb; Q9BLG4; -.
PRIDE; Q9BLG4; -.
EnsemblProtists; EAL68714; EAL68714; DDB_G0277503.
GeneID; 8621061; -.
KEGG; ddi:DDB_G0277503; -.
dictyBase; DDB_G0277503; amtA.
eggNOG; KOG0682; Eukaryota.
eggNOG; COG0004; LUCA.
InParanoid; Q9BLG4; -.
KO; K03320; -.
OMA; FLYAGMH; -.
PhylomeDB; Q9BLG4; -.
PRO; PR:Q9BLG4; -.
Proteomes; UP000002195; Chromosome 2.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0000421; C:autophagosome membrane; IDA:dictyBase.
GO; GO:0036020; C:endolysosome membrane; IDA:dictyBase.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030670; C:phagocytic vesicle membrane; IDA:dictyBase.
GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
GO; GO:0005774; C:vacuolar membrane; IDA:dictyBase.
GO; GO:0008519; F:ammonium transmembrane transporter activity; ISS:dictyBase.
GO; GO:0015696; P:ammonium transport; IMP:dictyBase.
GO; GO:0019954; P:asexual reproduction; IMP:dictyBase.
GO; GO:0007588; P:excretion; IMP:dictyBase.
GO; GO:0031159; P:positive regulation of aggregate size involved in sorocarp development; IMP:dictyBase.
GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
Gene3D; 1.10.3430.10; -; 1.
InterPro; IPR029020; Ammonium/urea_transptr.
InterPro; IPR001905; Ammonium_transpt.
InterPro; IPR018047; Ammonium_transpt_CS.
InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
Pfam; PF00909; Ammonium_transp; 1.
TIGRFAMs; TIGR00836; amt; 1.
PROSITE; PS01219; AMMONIUM_TRANSP; 1.
1: Evidence at protein level;
Ammonia transport; Cell membrane; Complete proteome;
Cytoplasmic vesicle; Endosome; Lysosome; Membrane; Reference proteome;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 463 Ammonium transporter 1.
/FTId=PRO_0000365573.
TOPO_DOM 1 39 Extracellular.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 40 60 Helical. {ECO:0000255}.
TOPO_DOM 61 76 Cytoplasmic.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 77 97 Helical. {ECO:0000255}.
TOPO_DOM 98 127 Extracellular.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 128 148 Helical. {ECO:0000255}.
TOPO_DOM 149 160 Cytoplasmic.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 161 181 Helical. {ECO:0000255}.
TOPO_DOM 182 194 Extracellular.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 195 215 Helical. {ECO:0000255}.
TOPO_DOM 216 233 Cytoplasmic.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 234 254 Helical. {ECO:0000255}.
TOPO_DOM 255 265 Extracellular.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 266 286 Helical. {ECO:0000255}.
TOPO_DOM 287 293 Cytoplasmic.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 294 314 Helical. {ECO:0000255}.
TOPO_DOM 315 316 Extracellular.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 317 337 Helical. {ECO:0000255}.
TOPO_DOM 338 351 Cytoplasmic.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 352 372 Helical. {ECO:0000255}.
TOPO_DOM 373 392 Extracellular.
{ECO:0000269|PubMed:19108721}.
TRANSMEM 393 413 Helical. {ECO:0000255}.
TOPO_DOM 414 463 Cytoplasmic.
{ECO:0000269|PubMed:19108721}.
SEQUENCE 463 AA; 49051 MW; 5EAF9DD8A69EAD80 CRC64;
MVAGEIIKGV AAEITNGSSS SVVQKYLDCA NQVAPDPGNT TWVLLSTILV LGMMPALAFF
EAGLLRSKNT LSIITQIMSG IVVLTVMWQA FGYSLTFGPD QKGIIGNLDH AFLINVSYDD
CSPNAPNIPA AAYAFFMMMF ANITPLLMTG AFAERVKFKA FIALTVAWEI IVFYPVAHWI
WGGGWLHKYF GVLDFAGGIV IHTSAGVSAL VIALYVGRRK DFEKYGGEFP PSNLPLATIG
AALLWMGWFG FNAGSALAAG NIATSAVAST QIGGSFSAIV WIILSAAKGK PNTVSVINGV
IAGLAGITPA SGYINSQYSI GLGICLGLAS YYSVVLLKHK LHIDDALDVS SVHGLTGIIG
SLAIGFCAEL SVNPNGANGA FYGNPKLIGT QLLGVVSVAV WAAAWTWVLL KIIDATIGVK
IDESEEELGL DLVEHGEFAY HNISLQGNEN HYSSVINSHD FFK


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