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Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein) (Rh family type C glycoprotein) (Rh type C glycoprotein)

 RHCG_CANLF              Reviewed;         460 AA.
Q3BCQ4;
03-APR-2007, integrated into UniProtKB/Swiss-Prot.
22-NOV-2005, sequence version 1.
28-MAR-2018, entry version 74.
RecName: Full=Ammonium transporter Rh type C;
AltName: Full=Rhesus blood group family type C glycoprotein;
Short=Rh family type C glycoprotein;
Short=Rh type C glycoprotein;
Name=RHCG;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=16227429; DOI=10.1073/pnas.0507886102;
Huang C.-H., Peng J.;
"Evolutionary conservation and diversification of Rh family genes and
proteins.";
Proc. Natl. Acad. Sci. U.S.A. 102:15512-15517(2005).
-!- FUNCTION: Functions as an electroneutral and bidirectional
ammonium transporter. May regulate transepithelial ammonia
secretion (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homotrimer.
-!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-
pass membrane protein {ECO:0000250}. Note=Also detected at the
basolateral membrane and in subapical vesicles. {ECO:0000250}.
-!- PTM: N-glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49)
family. Rh subfamily. {ECO:0000305}.
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EMBL; AY831678; AAX39720.1; -; mRNA.
RefSeq; NP_001041487.1; NM_001048022.1.
UniGene; Cfa.6938; -.
ProteinModelPortal; Q3BCQ4; -.
SMR; Q3BCQ4; -.
STRING; 9615.ENSCAFP00000017570; -.
PaxDb; Q3BCQ4; -.
Ensembl; ENSCAFT00000018959; ENSCAFP00000017570; ENSCAFG00000011927.
GeneID; 479040; -.
KEGG; cfa:479040; -.
CTD; 51458; -.
VGNC; VGNC:45550; RHCG.
eggNOG; KOG3796; Eukaryota.
eggNOG; ENOG410XTF8; LUCA.
GeneTree; ENSGT00390000005787; -.
HOGENOM; HOG000007656; -.
HOVERGEN; HBG004374; -.
InParanoid; Q3BCQ4; -.
KO; K06580; -.
OMA; DLENEFY; -.
OrthoDB; EOG091G06KX; -.
TreeFam; TF314450; -.
Reactome; R-CFA-444411; Rhesus glycoproteins mediate ammonium transport.
Proteomes; UP000002254; Chromosome 3.
Bgee; ENSCAFG00000011927; -.
GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0008519; F:ammonium transmembrane transporter activity; IDA:UniProtKB.
GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0015696; P:ammonium transport; IDA:UniProtKB.
GO; GO:0006873; P:cellular ion homeostasis; IEA:Ensembl.
GO; GO:0015695; P:organic cation transport; IBA:GO_Central.
GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
GO; GO:0070634; P:transepithelial ammonium transport; IEA:Ensembl.
Gene3D; 1.10.3430.10; -; 1.
InterPro; IPR029020; Ammonium/urea_transptr.
InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
InterPro; IPR002229; RhesusRHD.
Pfam; PF00909; Ammonium_transp; 1.
PRINTS; PR00342; RHESUSRHD.
2: Evidence at transcript level;
Ammonia transport; Cell membrane; Complete proteome; Glycoprotein;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 460 Ammonium transporter Rh type C.
/FTId=PRO_0000283576.
TOPO_DOM 1 9 Cytoplasmic. {ECO:0000255}.
TRANSMEM 10 30 Helical. {ECO:0000255}.
TOPO_DOM 31 61 Extracellular. {ECO:0000255}.
TRANSMEM 62 82 Helical. {ECO:0000255}.
TOPO_DOM 83 90 Cytoplasmic. {ECO:0000255}.
TRANSMEM 91 111 Helical. {ECO:0000255}.
TOPO_DOM 112 125 Extracellular. {ECO:0000255}.
TRANSMEM 126 145 Helical. {ECO:0000255}.
TOPO_DOM 146 151 Cytoplasmic. {ECO:0000255}.
TRANSMEM 152 174 Helical. {ECO:0000255}.
TOPO_DOM 175 179 Extracellular. {ECO:0000255}.
TRANSMEM 180 200 Helical. {ECO:0000255}.
TOPO_DOM 201 219 Cytoplasmic. {ECO:0000255}.
TRANSMEM 220 240 Helical. {ECO:0000255}.
TOPO_DOM 241 251 Extracellular. {ECO:0000255}.
TRANSMEM 252 272 Helical. {ECO:0000255}.
TOPO_DOM 273 285 Cytoplasmic. {ECO:0000255}.
TRANSMEM 286 306 Helical. {ECO:0000255}.
TOPO_DOM 307 307 Extracellular. {ECO:0000255}.
TRANSMEM 308 328 Helical. {ECO:0000255}.
TOPO_DOM 329 339 Cytoplasmic. {ECO:0000255}.
TRANSMEM 340 360 Helical. {ECO:0000255}.
TOPO_DOM 361 396 Extracellular. {ECO:0000255}.
TRANSMEM 397 417 Helical. {ECO:0000255}.
TOPO_DOM 418 460 Cytoplasmic. {ECO:0000255}.
CARBOHYD 48 48 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 460 AA; 50799 MW; 11D3BB0D9BE68841 CRC64;
MVWNTNLRWR LPVTCLLLQV ALVVLFGVFV RYDMDADPHW IDKKEAENST SDMENEFYYR
YPSFQDVHVM IFVGFGFLMT FLQRYGYSSV GFNFLLAAFG IQWALLLQGW FHSYYRGYIR
VGVENLINAD FCVGSVCVAF GAVLGKVSPV QLLIMTLFQV TLFSVNEFIL LNLLEVKDAG
GSMTIHTFGA YFGLTVTWIL YRPGLHQSKE RQSSVYHSDL FAMIGTLFLW MYWPSFNSAV
SNHGDAQHRA AINTYCSLAA CVLTSVALSS ALHKKGKLDM VHIQNATLAG GVAVGTAAEM
MLMPYGSLIV GFICGIVSTL GFVYLTPFLE SRLRVQDTCG IHNLHGIPGI IGAIVGAVTA
SCANTDVYGV NGLTQAFGFD GFKTNRTPSM QGKFQAAGLF VSLAMALVGG IIVGIILKLP
FWGQPADENC FEDAIYWEMP EEPKSTVLHP EDSTLKPSEP


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