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Angio-associated migratory cell protein

 AAMP_PONAB              Reviewed;         434 AA.
Q5RCG7; Q5RA18;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
26-APR-2005, sequence version 2.
25-OCT-2017, entry version 78.
RecName: Full=Angio-associated migratory cell protein;
Name=AAMP;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex, and Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays a role in angiogenesis and cell migration. In
smooth muscle cell migration, may act through the RhoA pathway (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
{ECO:0000250}.
-!- SEQUENCE CAUTION:
Sequence=CAH91392.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; CR858303; CAH90540.1; -; mRNA.
EMBL; CR859206; CAH91392.1; ALT_INIT; mRNA.
RefSeq; NP_001125288.1; NM_001131816.1.
ProteinModelPortal; Q5RCG7; -.
SMR; Q5RCG7; -.
STRING; 9601.ENSPPYP00000014710; -.
Ensembl; ENSPPYT00000015307; ENSPPYP00000014710; ENSPPYG00000013166.
GeneID; 100172186; -.
KEGG; pon:100172186; -.
CTD; 14; -.
eggNOG; KOG0296; Eukaryota.
eggNOG; ENOG410XR6A; LUCA.
GeneTree; ENSGT00870000136531; -.
HOVERGEN; HBG061307; -.
InParanoid; Q5RCG7; -.
OMA; CTNNGPV; -.
OrthoDB; EOG091G093C; -.
TreeFam; TF314543; -.
Proteomes; UP000001595; Chromosome 2b.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
GO; GO:0014909; P:smooth muscle cell migration; ISS:UniProtKB.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF00400; WD40; 5.
SMART; SM00320; WD40; 8.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 1.
PROSITE; PS50082; WD_REPEATS_2; 6.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
2: Evidence at transcript level;
Angiogenesis; Cell membrane; Complete proteome; Cytoplasm;
Developmental protein; Differentiation; Membrane; Phosphoprotein;
Reference proteome; Repeat; WD repeat.
CHAIN 1 434 Angio-associated migratory cell protein.
/FTId=PRO_0000050833.
REPEAT 89 129 WD 1.
REPEAT 132 171 WD 2.
REPEAT 173 212 WD 3.
REPEAT 214 254 WD 4.
REPEAT 258 299 WD 5.
REPEAT 315 354 WD 6.
REPEAT 356 395 WD 7.
REPEAT 398 433 WD 8.
COMPBIAS 53 59 Poly-Glu.
MOD_RES 20 20 Phosphoserine.
{ECO:0000250|UniProtKB:Q13685}.
CONFLICT 86 86 T -> I (in Ref. 1; CAH90540).
{ECO:0000305}.
CONFLICT 125 125 E -> G (in Ref. 1; CAH90540).
{ECO:0000305}.
CONFLICT 193 194 TA -> H (in Ref. 1; CAH90540).
{ECO:0000305}.
SEQUENCE 434 AA; 46781 MW; 16B3815553EBA3B2 CRC64;
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG
NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR
LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM
EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR
IWDLKQGSPI HVLKGTEGHQ GPLTCVATNQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG
IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG
DHKAKVFCVQ RPDR


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