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Angiotensinogen

 H0ZI58_TAEGU            Unreviewed;       462 AA.
H0ZI58;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
28-MAR-2018, entry version 48.
SubName: Full=Angiotensinogen {ECO:0000313|Ensembl:ENSTGUP00000010275};
Name=AGT {ECO:0000313|Ensembl:ENSTGUP00000010275};
Taeniopygia guttata (Zebra finch) (Poephila guttata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
Estrildidae; Estrildinae; Taeniopygia.
NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010275, ECO:0000313|Proteomes:UP000007754};
[1] {ECO:0000313|Ensembl:ENSTGUP00000010275, ECO:0000313|Proteomes:UP000007754}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20360741; DOI=10.1038/nature08819;
Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
"The genome of a songbird.";
Nature 464:757-762(2010).
[2] {ECO:0000313|Ensembl:ENSTGUP00000010275}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the serpin family.
{ECO:0000256|RuleBase:RU000411, ECO:0000256|SAAS:SAAS00596534}.
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EMBL; ABQF01014679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 59729.ENSTGUP00000010275; -.
Ensembl; ENSTGUT00000010384; ENSTGUP00000010275; ENSTGUG00000009957.
eggNOG; KOG2392; Eukaryota.
eggNOG; COG4826; LUCA.
GeneTree; ENSGT00890000139531; -.
InParanoid; H0ZI58; -.
OMA; RFMQAVT; -.
OrthoDB; EOG091G077M; -.
TreeFam; TF343201; -.
Reactome; R-TGU-2022377; Metabolism of Angiotensinogen to Angiotensins.
Reactome; R-TGU-375276; Peptide ligand-binding receptors.
Reactome; R-TGU-416476; G alpha (q) signalling events.
Reactome; R-TGU-418594; G alpha (i) signalling events.
Proteomes; UP000007754; Chromosome 3.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0031702; F:type 1 angiotensin receptor binding; IEA:Ensembl.
GO; GO:0031703; F:type 2 angiotensin receptor binding; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IEA:Ensembl.
GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0010873; P:positive regulation of cholesterol esterification; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:1903779; P:regulation of cardiac conduction; IEA:Ensembl.
GO; GO:1901201; P:regulation of extracellular matrix assembly; IEA:Ensembl.
GO; GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; IEA:InterPro.
GO; GO:0003014; P:renal system process; IEA:Ensembl.
InterPro; IPR000227; Angiotensinogen.
InterPro; IPR023795; Serpin_CS.
InterPro; IPR023796; Serpin_dom.
InterPro; IPR000215; Serpin_fam.
InterPro; IPR036186; Serpin_sf.
PANTHER; PTHR11461; PTHR11461; 1.
PANTHER; PTHR11461:SF13; PTHR11461:SF13; 1.
Pfam; PF00079; Serpin; 1.
PRINTS; PR00654; ANGIOTENSNGN.
SMART; SM00093; SERPIN; 1.
SUPFAM; SSF56574; SSF56574; 2.
PROSITE; PS00284; SERPIN; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000007754};
Reference proteome {ECO:0000313|Proteomes:UP000007754};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 462 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003546672.
DOMAIN 98 459 SERPIN. {ECO:0000259|SMART:SM00093}.
SEQUENCE 462 AA; 50803 MW; 073BC6CE747CCFFB CRC64;
TMNLVADLLY LLACLTMVTC DRVYVHPFTL FCFNESDCDK LEKLVQEGKT IVPVSIESQT
TPEYEAGMNE NKLEAPSLST WGKEERSYLS DLVYVLGMRF YSVLQKAQRG QNVLLSPTSL
YSSLVSFYLG ASNQTALDLQ GLLGFVPPSG NPDCTSTAVG RNFLSSLRTI ERLVKSGDEE
LLFSNTLSLF SAPGVPLFQL FMEHLLPSAD AFYARAVDFA NPGEAAKQIN AFVEAKSEGQ
SKGLLADINP STQLLLAEDV RLAVNVKQAF LLKEPQEFFV DSNTKVLVPM LSIMGTFKYK
TDASGTFSVV EIPISKTALL VLLQPINGSD LESVESKLTW QSSAWLQWLS PREIKLVLPA
LTLEDSSDLQ ELLADMELPE LLGKGADFSK ISNASLTVGK VINKAFFKLA SDGTDQPEDP
AAQKEDGAYL DVTLNKPFLF AVFEKQSRAM LFLGRVVNPL HE


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