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Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]

 ANGT_GORGO              Reviewed;         485 AA.
Q9GLP6;
29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
22-NOV-2017, entry version 67.
RecName: Full=Angiotensinogen;
AltName: Full=Serpin A8;
Contains:
RecName: Full=Angiotensin-1;
AltName: Full=Angiotensin 1-10;
AltName: Full=Angiotensin I;
Short=Ang I;
Contains:
RecName: Full=Angiotensin-2;
AltName: Full=Angiotensin 1-8;
AltName: Full=Angiotensin II;
Short=Ang II;
Contains:
RecName: Full=Angiotensin-3;
AltName: Full=Angiotensin 2-8;
AltName: Full=Angiotensin III;
Short=Ang III;
AltName: Full=Des-Asp[1]-angiotensin II;
Contains:
RecName: Full=Angiotensin-4;
AltName: Full=Angiotensin 3-8;
AltName: Full=Angiotensin IV;
Short=Ang IV;
Contains:
RecName: Full=Angiotensin 1-9;
Contains:
RecName: Full=Angiotensin 1-7;
Contains:
RecName: Full=Angiotensin 1-5;
Contains:
RecName: Full=Angiotensin 1-4;
Flags: Precursor;
Name=AGT; Synonyms=SERPINA8;
Gorilla gorilla gorilla (Western lowland gorilla).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Gorilla.
NCBI_TaxID=9595;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Shattuck-Eidens D., McGrail M., Stone S.;
"Germline mutations in the angiotensinogen gene cause predisposition
to type 1 diabetes mellitus.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Essential component of the renin-angiotensin system
(RAS), a potent regulator of blood pressure, body fluid and
electrolyte homeostasis. {ECO:0000250}.
-!- FUNCTION: Angiotensin-2: acts directly on vascular smooth muscle
as a potent vasoconstrictor, affects cardiac contractility and
heart rate through its action on the sympathetic nervous system,
and alters renal sodium and water absorption through its ability
to stimulate the zona glomerulosa cells of the adrenal cortex to
synthesize and secrete aldosterone. {ECO:0000250}.
-!- FUNCTION: Angiotensin-3: stimulates aldosterone release.
{ECO:0000250}.
-!- FUNCTION: Angiotensin 1-7: is a ligand for the G-protein coupled
receptor MAS1. Has vasodilator and antidiuretic effects. Has an
antithrombotic effect that involves MAS1-mediated release of
nitric oxide from platelets. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- PTM: In response to low blood pressure, the enzyme renin/REN
cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is
a substrate of ACE (angiotensin converting enzyme) that removes a
dipeptide to yield the physiologically active peptide angiotensin-
2. Angiotensin-1 and angiotensin-2 can be further processed to
generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved
from angiotensin-1 by ACE2 and can be further processed by ACE to
produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4.
Angiotensin 1-7 has also been proposed to be cleaved from
angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin)
(By similarity). {ECO:0000250}.
-!- PTM: The disulfide bond is labile. Angiotensinogen is present in
the circulation in a near 40:60 ratio with the oxidized disulfide-
bonded form, which preferentially interacts with receptor-bound
renin (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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EMBL; AF188488; AAG29057.1; -; mRNA.
RefSeq; NP_001266554.1; NM_001279625.1.
ProteinModelPortal; Q9GLP6; -.
STRING; 9593.ENSGGOP00000000194; -.
MEROPS; I04.953; -.
PRIDE; Q9GLP6; -.
GeneID; 101141078; -.
CTD; 183; -.
HOVERGEN; HBG004233; -.
InParanoid; Q9GLP6; -.
Proteomes; UP000001519; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; IEA:InterPro.
GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
CDD; cd02054; angiotensinogen; 1.
InterPro; IPR000227; Angiotensinogen.
InterPro; IPR033834; Angiotensinogen_serpin.
InterPro; IPR023795; Serpin_CS.
InterPro; IPR023796; Serpin_dom.
InterPro; IPR000215; Serpin_fam.
InterPro; IPR036186; Serpin_sf.
PANTHER; PTHR11461; PTHR11461; 1.
PANTHER; PTHR11461:SF13; PTHR11461:SF13; 1.
Pfam; PF00079; Serpin; 1.
PRINTS; PR00654; ANGIOTENSNGN.
SMART; SM00093; SERPIN; 1.
SUPFAM; SSF56574; SSF56574; 1.
PROSITE; PS00284; SERPIN; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
Secreted; Signal; Vasoactive; Vasoconstrictor.
SIGNAL 1 33 {ECO:0000255}.
CHAIN 34 485 Angiotensinogen.
/FTId=PRO_0000032449.
PEPTIDE 34 43 Angiotensin-1.
/FTId=PRO_0000032450.
PEPTIDE 34 42 Angiotensin 1-9.
/FTId=PRO_0000420649.
PEPTIDE 34 41 Angiotensin-2.
/FTId=PRO_0000032451.
PEPTIDE 34 40 Angiotensin 1-7.
/FTId=PRO_0000420650.
PEPTIDE 34 38 Angiotensin 1-5.
/FTId=PRO_0000420651.
PEPTIDE 34 37 Angiotensin 1-4.
/FTId=PRO_0000420652.
PEPTIDE 35 41 Angiotensin-3.
/FTId=PRO_0000032452.
PEPTIDE 36 41 Angiotensin-4.
/FTId=PRO_0000420653.
CARBOHYD 47 47 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 170 170 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 304 304 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 328 328 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 51 171 {ECO:0000250}.
SEQUENCE 485 AA; 53186 MW; 53BC9235271C8255 CRC64;
MRKRAPQSEM APAGMSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG
KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM
HSELWGVVHG ATVLSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDKN CTSRLDAHKV
LSALQAVQGL LVAQGRADSQ AQLLLSTVVG VFTAPSLHLK QPFVQGLALY TPVVLPRSLD
FTELDVAAEK IDRFMQAVTG WKTGCSLTGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT
FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE LPAILHTELN LQKLSNDRIR
VGEVLNSIFF ELEADEREPT ESTQQLNKPE VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN
PLSTA


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