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Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein) (B3RP) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2)

 B3A2_MOUSE              Reviewed;        1237 AA.
P13808; Q9ES09; Q9ES10; Q9ES11; Q9ES12; Q9ES13;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
30-AUG-2017, entry version 152.
RecName: Full=Anion exchange protein 2;
Short=AE 2;
Short=Anion exchanger 2;
AltName: Full=Band 3-related protein;
Short=B3RP;
AltName: Full=Non-erythroid band 3-like protein;
AltName: Full=Solute carrier family 4 member 2;
Name=Slc4a2; Synonyms=Ae2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
PubMed=3182834;
Alper S.L., Kopito R.R., Libresco S.M., Lodish H.F.;
"Cloning and characterization of a murine band 3-related cDNA from
kidney and from a lymphoid cell line.";
J. Biol. Chem. 263:17092-17099(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND TISSUE
SPECIFICITY.
PubMed=11006093; DOI=10.1006/bbrc.2000.3439;
Lecanda J., Urtasun R., Medina J.F.;
"Molecular cloning and genomic organization of the mouse AE2 anion
exchanger gene.";
Biochem. Biophys. Res. Commun. 276:117-124(2000).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-170; SER-172
AND THR-253, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, Lung, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plasma membrane anion exchange protein of wide
distribution.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=A;
IsoId=P13808-1; Sequence=Displayed;
Name=B1;
IsoId=P13808-2; Sequence=VSP_000458;
Name=B2;
IsoId=P13808-3; Sequence=VSP_000457;
Name=C1;
IsoId=P13808-4; Sequence=VSP_000460;
Name=C2;
IsoId=P13808-5; Sequence=VSP_000459, VSP_000461;
-!- TISSUE SPECIFICITY: Isoform a is widely expressed at similar
levels in all tissues examined. Isoforms B1 and B2 are
predominantly expressed in stomach although they are also detected
at lower levels in other tissues. Isoform C1 is stomach-specific.
Isoform C2 is expressed at slightly higher levels in lung and
stomach than in other tissues. {ECO:0000269|PubMed:11006093}.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; J04036; AAA65505.1; -; mRNA.
EMBL; AF255774; AAG23154.1; -; Genomic_DNA.
EMBL; AF255774; AAG23155.1; -; Genomic_DNA.
EMBL; AF255774; AAG23156.1; -; Genomic_DNA.
EMBL; AF255774; AAG23158.1; -; Genomic_DNA.
EMBL; AF255774; AAG23157.1; -; Genomic_DNA.
CCDS; CCDS19119.1; -. [P13808-1]
PIR; A31789; A31789.
RefSeq; NP_001240821.1; NM_001253892.1.
RefSeq; NP_033233.2; NM_009207.3.
RefSeq; XP_006535713.1; XM_006535650.1.
RefSeq; XP_006535714.1; XM_006535651.3.
RefSeq; XP_006535718.1; XM_006535655.3.
RefSeq; XP_006535719.1; XM_006535656.3.
UniGene; Mm.4580; -.
ProteinModelPortal; P13808; -.
SMR; P13808; -.
IntAct; P13808; 1.
MINT; MINT-4088942; -.
STRING; 10090.ENSMUSP00000078972; -.
iPTMnet; P13808; -.
PhosphoSitePlus; P13808; -.
MaxQB; P13808; -.
PaxDb; P13808; -.
PeptideAtlas; P13808; -.
PRIDE; P13808; -.
GeneID; 20535; -.
KEGG; mmu:20535; -.
UCSC; uc008wrm.2; mouse. [P13808-1]
CTD; 6522; -.
MGI; MGI:109351; Slc4a2.
eggNOG; KOG1172; Eukaryota.
eggNOG; ENOG410XPHD; LUCA.
HOGENOM; HOG000280683; -.
HOVERGEN; HBG004326; -.
InParanoid; P13808; -.
KO; K13855; -.
PhylomeDB; P13808; -.
TreeFam; TF313630; -.
ChiTaRS; Slc4a2; mouse.
PRO; PR:P13808; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI.
GO; GO:0005925; C:focal adhesion; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
GO; GO:0015108; F:chloride transmembrane transporter activity; IDA:UniProtKB.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
GO; GO:0008510; F:sodium:bicarbonate symporter activity; IBA:GO_Central.
GO; GO:0006821; P:chloride transport; IDA:UniProtKB.
GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR001717; Anion_exchange.
InterPro; IPR002978; Anion_exchange_2.
InterPro; IPR018241; Anion_exchange_CS.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
PANTHER; PTHR11453:SF67; PTHR11453:SF67; 1.
Pfam; PF07565; Band_3_cyto; 1.
Pfam; PF00955; HCO3_cotransp; 1.
PRINTS; PR00165; ANIONEXCHNGR.
PRINTS; PR01188; ANIONEXHNGR2.
PRINTS; PR01231; HCO3TRNSPORT.
SUPFAM; SSF55804; SSF55804; 2.
TIGRFAMs; TIGR00834; ae; 1.
PROSITE; PS00219; ANION_EXCHANGER_1; 1.
PROSITE; PS00220; ANION_EXCHANGER_2; 1.
1: Evidence at protein level;
Alternative splicing; Anion exchange; Antiport; Complete proteome;
Glycoprotein; Ion transport; Lipoprotein; Membrane; Methylation;
Palmitate; Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 1237 Anion exchange protein 2.
/FTId=PRO_0000079216.
TOPO_DOM 1 703 Cytoplasmic. {ECO:0000255}.
TRANSMEM 704 727 Helical. {ECO:0000255}.
TRANSMEM 733 770 Helical. {ECO:0000255}.
TRANSMEM 790 812 Helical. {ECO:0000255}.
TRANSMEM 822 843 Helical. {ECO:0000255}.
TOPO_DOM 844 896 Extracellular. {ECO:0000255}.
TRANSMEM 897 914 Helical. {ECO:0000255}.
TOPO_DOM 915 929 Cytoplasmic. {ECO:0000255}.
TRANSMEM 930 950 Helical. {ECO:0000255}.
TRANSMEM 984 1006 Helical. {ECO:0000255}.
TRANSMEM 1032 1053 Helical. {ECO:0000255}.
TRANSMEM 1087 1132 Helical. {ECO:0000255}.
TRANSMEM 1159 1195 Helical. {ECO:0000255}.
REGION 704 1237 Membrane (anion exchange).
COMPBIAS 5 316 Pro-rich.
COMPBIAS 73 87 His-rich.
COMPBIAS 861 865 Poly-Ser.
MOD_RES 112 112 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 131 131 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 144 144 Phosphoserine.
{ECO:0000244|PubMed:19144319}.
MOD_RES 170 170 Phosphoserine.
{ECO:0000244|PubMed:19144319}.
MOD_RES 172 172 Phosphoserine.
{ECO:0000244|PubMed:19144319}.
MOD_RES 239 239 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 253 253 Phosphothreonine.
{ECO:0000244|PubMed:19144319}.
MOD_RES 270 270 N6-methyllysine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 297 297 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:P16283}.
MOD_RES 439 439 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
LIPID 1169 1169 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 855 855 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 866 866 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 878 878 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 1 198 Missing (in isoform C1). {ECO:0000305}.
/FTId=VSP_000460.
VAR_SEQ 1 166 Missing (in isoform C2). {ECO:0000305}.
/FTId=VSP_000459.
VAR_SEQ 1 17 MSSAPRRPASGADSLHT -> MTQ (in isoform B1).
{ECO:0000305}.
/FTId=VSP_000458.
VAR_SEQ 1 17 MSSAPRRPASGADSLHT -> MDFLLRPQ (in isoform
B2). {ECO:0000305}.
/FTId=VSP_000457.
VAR_SEQ 167 193 ERTSPSPPTQTPHQEAAPRASKGAQTG -> MPAFQEWKSG
GLREEAVFGAHGCSVCR (in isoform C2).
{ECO:0000305}.
/FTId=VSP_000461.
CONFLICT 205 205 A -> G (in Ref. 2; AAG23154/AAG23155/
AAG23156/AAG23158/AAG23157).
{ECO:0000305}.
SEQUENCE 1237 AA; 136814 MW; 1A0782C0071782EE CRC64;
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEDELRT LGVERFEEIL QEAGSRGGEE
PGRSYGEEDF EYHRQSSHHI HHPLSTHLPP DARRRKTPQG PGRKPRRRPG ASPTGETPTI
EEGEEDEEEA SEAEGFRAPP QQPSPATTPS AVQFFLQEDE GAERKPERTS PSPPTQTPHQ
EAAPRASKGA QTGTLVEEMV AVASATAGGD DGGAAGRPLT KAQPGHRSYN LQERRRIGSM
TGVEQALLPR VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQAAREGR
EPGPTPRARP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH
VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL
LKHSHPSDEK EFSFPRNISA GSLGSLLGHH HAQGTESDPH VTEPLIGGVP ETRLEVDRER
ELPPPAPPAG ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD
AVLEVPVPVR FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE RDDLLTAINA
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGAGLEPKS AQDKALLQMV
EVAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL DPQCLAAVIF IYFAALSPAI
TFGGLLGEKT KDLIGVSELI MSTALQGVVF CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS
NELEYLVGRV WIGFWLVFLA LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI
KIFQEHPLHG CSGSNDSEAG SSSSSNMTWA TTILVPDNSS ASGQSGQEKP RGQPNTALLS
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI EDTYTQKLSV
PSGFSVTAPD KRGWVINPLG EKTPFPVWMM VASLLPAVLV FILIFMETQI TTLIISKKER
MLQKGSGFHL DLLLIVAMGG ICALFGLPWL AAATVRSVTH ANALTVMSKA VAPGDKPKIQ
EVKEQRVTGL LVALLVGLSM VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM
PPKHHPDVTY VKKVRTMRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
TRIFTEREMK CLDANEAEPV FDECEGVDEY NEMPMPV


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