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Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein) (B3RP) (Solute carrier family 4 member 2)

 B3A2_RABIT              Reviewed;        1237 AA.
P48746;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
25-OCT-2017, entry version 104.
RecName: Full=Anion exchange protein 2;
Short=AE 2;
Short=Anion exchanger 2;
AltName: Full=Band 3-related protein;
Short=B3RP;
AltName: Full=Solute carrier family 4 member 2;
Name=SLC4A2; Synonyms=AE2;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white;
PubMed=1415547;
Chow A., Dobbins J.W., Aronson P.S., Igarashi P.;
"cDNA cloning and localization of a band 3-related protein from
ileum.";
Am. J. Physiol. 263:G345-G352(1992).
-!- FUNCTION: Plasma membrane anion exchange protein of wide
distribution.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; S45791; AAB23488.1; -; mRNA.
PIR; A56764; A56764.
RefSeq; NP_001075788.1; NM_001082319.1.
UniGene; Ocu.3310; -.
ProteinModelPortal; P48746; -.
SMR; P48746; -.
PRIDE; P48746; -.
GeneID; 100009159; -.
KEGG; ocu:100009159; -.
CTD; 6522; -.
HOVERGEN; HBG004326; -.
InParanoid; P48746; -.
KO; K13855; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR001717; Anion_exchange.
InterPro; IPR002978; Anion_exchange_2.
InterPro; IPR018241; Anion_exchange_CS.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
PANTHER; PTHR11453:SF14; PTHR11453:SF14; 1.
Pfam; PF07565; Band_3_cyto; 1.
Pfam; PF00955; HCO3_cotransp; 1.
PRINTS; PR00165; ANIONEXCHNGR.
PRINTS; PR01188; ANIONEXHNGR2.
PRINTS; PR01231; HCO3TRNSPORT.
SUPFAM; SSF55804; SSF55804; 2.
TIGRFAMs; TIGR00834; ae; 1.
PROSITE; PS00219; ANION_EXCHANGER_1; 1.
PROSITE; PS00220; ANION_EXCHANGER_2; 1.
2: Evidence at transcript level;
Anion exchange; Antiport; Complete proteome; Glycoprotein;
Ion transport; Lipoprotein; Membrane; Methylation; Palmitate;
Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 1237 Anion exchange protein 2.
/FTId=PRO_0000079217.
TOPO_DOM 1 703 Cytoplasmic. {ECO:0000255}.
TRANSMEM 704 727 Helical. {ECO:0000255}.
TRANSMEM 733 770 Helical. {ECO:0000255}.
TRANSMEM 790 812 Helical. {ECO:0000255}.
TRANSMEM 822 843 Helical. {ECO:0000255}.
TOPO_DOM 844 896 Extracellular. {ECO:0000255}.
TRANSMEM 897 914 Helical. {ECO:0000255}.
TOPO_DOM 915 929 Cytoplasmic. {ECO:0000255}.
TRANSMEM 930 950 Helical. {ECO:0000255}.
TRANSMEM 984 1006 Helical. {ECO:0000255}.
TRANSMEM 1032 1053 Helical. {ECO:0000255}.
TRANSMEM 1087 1132 Helical. {ECO:0000255}.
TRANSMEM 1159 1195 Helical. {ECO:0000255}.
REGION 704 1237 Membrane (anion exchange).
COMPBIAS 5 316 Pro-rich.
COMPBIAS 74 88 His-rich.
MOD_RES 113 113 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 144 144 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 170 170 Phosphoserine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 172 172 Phosphoserine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 239 239 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 253 253 Phosphothreonine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 270 270 N6-methyllysine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 297 297 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:P16283}.
MOD_RES 439 439 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
LIPID 1169 1169 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 855 855 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 864 864 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 878 878 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 1237 AA; 136536 MW; 2811D11051552BB2 CRC64;
MSSAPRRPAS GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI LQEAGSRGGE
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGATPT
IEEGEEDEEE ANEAEGARAP TEPSPASTPS SVQFFLQEDE GAERKAERTS PSPPTLLPHQ
EAAPWATEGA QTGVPVEEVA VVASGTAGGD NGGASGRPLT KAQPGHRSYN LQERRRIGSM
TGAEQALLPR VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSAQSSREGR
EPGPTPRSRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH
VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL
LKHSHPSDEK DFSFPRNISA GSLGSLLGHH HGQGAESDPH VTEPLIGGIP ETRLDVERER
DVPPSAPPAG ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD
AVLEVPVPVR FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGLGLEPKS AQDKALLQMV
EAAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL DPQCVAAVIF IYFAALSPAI
TFGGLLGEKT QDLIGVSELI MSTALQGVIF CLLGAQPLLV IGFSGPLLVF EEAFFTFCSS
NQLEYLVGRV WIGFWLVLLA LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI
KIFQEHPLHG CSVSNSSETD SSENATWAGA GSTLGPANRS SAGQAGQGRP RGQPNTALLS
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI EDTYTQKLSV
PSGFSVTAPD KRGWVINPLG EKSPFPVWMM VASLLPAILV FILIFMETQI TTLIISKKER
MLQKGSGFHL DLLLIVAMGG ICALFGLPWL AAATVRSVTH ANALTVMSKA VAPGDKPKIQ
EVKEQRVTGL LVALLVGLSI VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM
PPKHHPDVTY VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
TRIFTEREMK CLDANEAEPV FDEREGVDEY NEMPMPV


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