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Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein 2) (B3RP-2) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2)

 B3A2_RAT                Reviewed;        1234 AA.
P23347;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 1.
25-OCT-2017, entry version 134.
RecName: Full=Anion exchange protein 2;
Short=AE 2;
Short=Anion exchanger 2;
AltName: Full=Band 3-related protein 2;
Short=B3RP-2;
AltName: Full=Non-erythroid band 3-like protein;
AltName: Full=Solute carrier family 4 member 2;
Name=Slc4a2; Synonyms=Ae2, B3rp2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Stomach;
PubMed=2294114;
Kudrycki K.E., Newman P.R., Shull G.E.;
"cDNA cloning and tissue distribution of mRNAs for two proteins that
are related to the band 3 Cl-/HCO3-exchanger.";
J. Biol. Chem. 265:462-471(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=2371270; DOI=10.1073/pnas.87.14.5278;
Lindsey A.E., Schneider K., Simmons D.M., Baron R., Lee B.S.,
Kopito R.R.;
"Functional expression and subcellular localization of an anion
exchanger cloned from choroid plexus.";
Proc. Natl. Acad. Sci. U.S.A. 87:5278-5282(1990).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145 AND THR-254, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Plasma membrane anion exchange protein of wide
distribution.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; J05166; AAA40799.1; -; mRNA.
PIR; A34911; A34911.
RefSeq; NP_058744.1; NM_017048.2.
RefSeq; XP_006235936.1; XM_006235874.3.
RefSeq; XP_006235937.1; XM_006235875.3.
UniGene; Rn.9860; -.
ProteinModelPortal; P23347; -.
SMR; P23347; -.
BioGrid; 246904; 1.
STRING; 10116.ENSRNOP00000019666; -.
iPTMnet; P23347; -.
PhosphoSitePlus; P23347; -.
PaxDb; P23347; -.
PRIDE; P23347; -.
Ensembl; ENSRNOT00000019666; ENSRNOP00000019666; ENSRNOG00000014347.
GeneID; 24780; -.
KEGG; rno:24780; -.
CTD; 6522; -.
RGD; 3711; Slc4a2.
eggNOG; KOG1172; Eukaryota.
eggNOG; ENOG410XPHD; LUCA.
GeneTree; ENSGT00760000119021; -.
HOGENOM; HOG000280683; -.
HOVERGEN; HBG004326; -.
InParanoid; P23347; -.
KO; K13855; -.
OMA; PHKPHEV; -.
OrthoDB; EOG091G01FT; -.
PhylomeDB; P23347; -.
TreeFam; TF313630; -.
Reactome; R-RNO-425381; Bicarbonate transporters.
PRO; PR:P23347; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000014347; -.
Genevisible; P23347; RN.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
GO; GO:0019899; F:enzyme binding; IPI:RGD.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
GO; GO:0008510; F:sodium:bicarbonate symporter activity; IBA:GO_Central.
GO; GO:0048565; P:digestive tract development; IEP:RGD.
GO; GO:0051453; P:regulation of intracellular pH; IMP:RGD.
GO; GO:0007283; P:spermatogenesis; IEP:RGD.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR001717; Anion_exchange.
InterPro; IPR002978; Anion_exchange_2.
InterPro; IPR018241; Anion_exchange_CS.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
PANTHER; PTHR11453:SF14; PTHR11453:SF14; 1.
Pfam; PF07565; Band_3_cyto; 1.
Pfam; PF00955; HCO3_cotransp; 1.
PRINTS; PR00165; ANIONEXCHNGR.
PRINTS; PR01188; ANIONEXHNGR2.
PRINTS; PR01231; HCO3TRNSPORT.
SUPFAM; SSF55804; SSF55804; 2.
TIGRFAMs; TIGR00834; ae; 1.
PROSITE; PS00219; ANION_EXCHANGER_1; 1.
PROSITE; PS00220; ANION_EXCHANGER_2; 1.
1: Evidence at protein level;
Anion exchange; Antiport; Complete proteome; Glycoprotein;
Ion transport; Lipoprotein; Membrane; Methylation; Palmitate;
Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 1234 Anion exchange protein 2.
/FTId=PRO_0000079218.
TOPO_DOM 1 704 Cytoplasmic. {ECO:0000255}.
TRANSMEM 705 728 Helical. {ECO:0000255}.
TRANSMEM 734 771 Helical. {ECO:0000255}.
TRANSMEM 791 813 Helical. {ECO:0000255}.
TRANSMEM 823 843 Helical. {ECO:0000255}.
TOPO_DOM 844 893 Extracellular. {ECO:0000255}.
TRANSMEM 894 911 Helical. {ECO:0000255}.
TOPO_DOM 912 926 Cytoplasmic. {ECO:0000255}.
TRANSMEM 927 947 Helical. {ECO:0000255}.
TRANSMEM 981 1003 Helical. {ECO:0000255}.
TRANSMEM 1029 1050 Helical. {ECO:0000255}.
TRANSMEM 1084 1129 Helical. {ECO:0000255}.
TRANSMEM 1156 1192 Helical. {ECO:0000255}.
REGION 705 1234 Membrane (anion exchange).
COMPBIAS 5 317 Pro-rich.
COMPBIAS 74 88 His-rich.
MOD_RES 113 113 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 145 145 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 171 171 Phosphoserine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 173 173 Phosphoserine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 240 240 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 254 254 Phosphothreonine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 271 271 N6-methyllysine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 298 298 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:P16283}.
MOD_RES 440 440 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
LIPID 1166 1166 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 856 856 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 866 866 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 878 878 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 206 206 G -> A (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
CONFLICT 925 926 RR -> PG (in Ref. 2; no nucleotide
entry). {ECO:0000305}.
CONFLICT 1018 1019 ML -> IV (in Ref. 2; no nucleotide
entry). {ECO:0000305}.
CONFLICT 1156 1157 MH -> ID (in Ref. 2; no nucleotide
entry). {ECO:0000305}.
SEQUENCE 1234 AA; 136636 MW; FAB4ED12BB916216 CRC64;
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEEDELR TLGVERFEEI LQEAGSRGGE
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT
IEEGEEDEDE VGEAEGFRAP PQQPSPASSP SAVQFFLQED EGTDRKAERT SPSPPTQTPH
QEAAPRASKG AQTGTLVEEM VAVASGTAGG DDGGAAGRPL TKAQPGHRSY NLQERRRIGS
MTGVEQALLP RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG
REPGPTPRAR PRAPHKPHEV FVELNELQLD KNQEPQWRET ARWIKFEEDV EEETERWGKP
HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE QMVISDQIKA EDRANVLRAL
LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH HHAQGTESDP HVTEPLIGGV PETRLEVDRE
RELPPPAPPA GITRSKSKHE LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL
DAVLEVPVPV RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN
AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK SAQDKALLQM
VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA LDPQCLAAVI FIYFAALSPA
ITFGGLLGEK TQDLIGVSEL IMSTALQGVI FCLLGAQPLL VIGFSGPLLV FEEAFFSFCK
SNQLEYLVGR VWIGFWLVLL ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL
IKIFQEHPLH GCSVSNDSEA DSSSNNMTWA ATTLAPDNSS ASGQERPRGQ PNTALLSLVL
MAGTFFIAFF LRKFKNSRFF PGRIRRVIGD FGVPIAILIM VLVDYSIEDT YTQKLSVPSG
FSVTAPDKRG WVINPLGEKT PFPVWMMVAS LLPAVLVFIL IFMETQITTL IISKKERMLQ
KGSGFHLDLL LIVAMGGICA LFGLPWLAAA TVRSVTHANA LTVMSKAVAP GDKPKIQEVK
EQRVTGLLVA LLVGLSMVIG DLLRQIPLAV LFGIFLYMGV TSLNGIQFYE RLHLLLMPPK
HHPDVTYVKK VRTMRMHLFT ALQLLCLALL WAVMSTAASL AFPFILILTV PLRMVVLTRI
FTEREMKCLD ANEAEPVFDE CEGVDEYNEM PMPV


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