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Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2)

 B3A2_CAVPO              Reviewed;        1238 AA.
Q9Z0S8;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
10-MAY-2017, entry version 101.
RecName: Full=Anion exchange protein 2;
Short=AE 2;
Short=Anion exchanger 2;
AltName: Full=Non-erythroid band 3-like protein;
AltName: Full=Solute carrier family 4 member 2;
Name=SLC4A2; Synonyms=AE2;
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=NIH 2; TISSUE=Organ of Corti;
PubMed=9804866; DOI=10.1016/S0005-2736(98)00110-2;
Mhatre A.N., Charachon G., Alper A.L., Lalwani A.K.;
"The guinea pig cochlear AE2 anion exchanger: cDNA cloning and in situ
localization within the cochlea.";
Biochim. Biophys. Acta 1414:1-15(1998).
-!- FUNCTION: Plasma membrane anion exchange protein of wide
distribution.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; AF121253; AAD19700.1; -; mRNA.
RefSeq; NP_001166488.1; NM_001173017.1.
ProteinModelPortal; Q9Z0S8; -.
SMR; Q9Z0S8; -.
STRING; 10141.ENSCPOP00000011907; -.
GeneID; 100135618; -.
CTD; 6522; -.
eggNOG; KOG1172; Eukaryota.
eggNOG; ENOG410XPHD; LUCA.
HOGENOM; HOG000280683; -.
HOVERGEN; HBG004326; -.
InParanoid; Q9Z0S8; -.
Proteomes; UP000005447; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR001717; Anion_exchange.
InterPro; IPR002978; Anion_exchange_2.
InterPro; IPR018241; Anion_exchange_CS.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
PANTHER; PTHR11453:SF67; PTHR11453:SF67; 1.
Pfam; PF07565; Band_3_cyto; 1.
Pfam; PF00955; HCO3_cotransp; 1.
PRINTS; PR00165; ANIONEXCHNGR.
PRINTS; PR01188; ANIONEXHNGR2.
PRINTS; PR01231; HCO3TRNSPORT.
SUPFAM; SSF55804; SSF55804; 2.
TIGRFAMs; TIGR00834; ae; 1.
PROSITE; PS00219; ANION_EXCHANGER_1; 1.
PROSITE; PS00220; ANION_EXCHANGER_2; 1.
2: Evidence at transcript level;
Anion exchange; Antiport; Complete proteome; Glycoprotein;
Ion transport; Lipoprotein; Membrane; Methylation; Palmitate;
Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 1238 Anion exchange protein 2.
/FTId=PRO_0000079214.
TOPO_DOM 1 704 Cytoplasmic. {ECO:0000255}.
TRANSMEM 705 728 Helical. {ECO:0000255}.
TRANSMEM 734 771 Helical. {ECO:0000255}.
TRANSMEM 791 813 Helical. {ECO:0000255}.
TRANSMEM 823 844 Helical. {ECO:0000255}.
TOPO_DOM 845 897 Extracellular. {ECO:0000255}.
TRANSMEM 898 915 Helical. {ECO:0000255}.
TOPO_DOM 916 930 Cytoplasmic. {ECO:0000255}.
TRANSMEM 931 951 Helical. {ECO:0000255}.
TRANSMEM 985 1007 Helical. {ECO:0000255}.
TRANSMEM 1033 1054 Helical. {ECO:0000255}.
TRANSMEM 1088 1133 Helical. {ECO:0000255}.
TRANSMEM 1160 1196 Helical. {ECO:0000255}.
REGION 705 1238 Membrane (anion exchange).
COMPBIAS 5 316 Pro-rich.
COMPBIAS 74 88 His-rich.
MOD_RES 132 132 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 144 144 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 170 170 Phosphoserine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 172 172 Phosphoserine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 239 239 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 253 253 Phosphothreonine.
{ECO:0000250|UniProtKB:P13808}.
MOD_RES 270 270 N6-methyllysine.
{ECO:0000250|UniProtKB:P04920}.
MOD_RES 297 297 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:P16283}.
MOD_RES 439 439 Phosphoserine.
{ECO:0000250|UniProtKB:P04920}.
LIPID 1170 1170 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 856 856 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 865 865 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 879 879 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 1238 AA; 137360 MW; FA1739862ED5ADBF CRC64;
MSGTPRRPAS GADSFHKPEP EIVGPGTPGF PEQEEDDLHR TLGVERFEEI LQEAGSRGGE
ELGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GQVRKPRRRP GATPAGETPT
IEEGEEDEDE TSEAEGPVSH TDPSPASTPT SVQFFLQEDE GTDRKAERTS PSPPAQLPHQ
EAAPQATKKA QPDALVEEAI MVSGGTAGGD DGGASGRPLS KAQPGHRSYN LQERRRIGSM
TGVEQALLPR VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSSQSSREGR
EPGPTPRTRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH
VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL
LKHSHPSDEK EFSFPRNISA GSLGSLLGHH HTQGAESDPH VTEPLIGGVP ETRLEVERER
ELPPPAPPAG ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD
AVLEVPVPVR FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGVGLEPKS AQEKAFLQMV
EAVGAVEDDD PLRRTGRPFG GLIRDVKRRY PHYLSDFRDA LDPQCLAAVI FIYFAALSPA
ITFGGLLGEK THDLIGVSEL IMSTALQGVT FCLLGAQPLL VIGFSGPLLV FEEAFYSFCR
SNELEYLVGR VWIGFWLVLS ALLMVALEGS FLVRFGSRFT QEIFAFLISL IFIYETFYKL
VKIFQEHPLH GCLASNSSEA DGGKNTTWTE AAPTPGHGNT SSAEQAGVER PQGQPNTALL
SLVLMAGTFF IAFFLRKFKN SRFFPGRIRR VIGDFGVPIA ILIMVLVDYS IQDTYTQKLS
VPSGFSVTAP EKRGWIINPL GEEEPFPVWM MVASLLPAIL VFILIFMETQ ITTLIISKKE
RMLQKGSGFH LDLLLIVAMG GICALFGLLW LAAATVRSVT HANALTVMSK AVAPGDKPKI
QEVKEQRVTG LLVALLVGLS LVIGDLLRQI PLAVLFGIFL YMGVTSLNGI QFYERLHLLL
MPPKHHPDVM YVKKVRTMRM HLFKALQLLC LALLWAVMST AASLAFPFIL ILTVPLRMVV
LTRIFTEREM KCLDANEAEP VFDEREGVDE YNEMPMPV


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