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Anion exchange protein 3 (AE 3) (Anion exchanger 3) (Neuronal band 3-like protein) (Solute carrier family 4 member 3)

 B3A3_MOUSE              Reviewed;        1227 AA.
P16283; Q9ERP5;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
25-OCT-2017, entry version 151.
RecName: Full=Anion exchange protein 3;
Short=AE 3;
Short=Anion exchanger 3;
AltName: Full=Neuronal band 3-like protein;
AltName: Full=Solute carrier family 4 member 3;
Name=Slc4a3; Synonyms=Ae3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2686841; DOI=10.1016/0092-8674(89)90615-6;
Kopito R.R., Lee B.S., Simmons D.M., Lindsey A.E., Morgans C.W.,
Schneider K.;
"Regulation of intracellular pH by a neuronal homolog of the
erythrocyte anion exchanger.";
Cell 59:927-937(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
PubMed=8126106;
Morgans C.W., Kopito R.R.;
"Generation of truncated brain AE3 isoforms by alternate mRNA
processing.";
J. Cell Sci. 106:1275-1282(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=12592704; DOI=10.1080/1042517021000011654;
Iwaasa M., Tatewaki H., Ohno T., Okubo K., Hamasaki N., Kang D.;
"Genomic cloning and promoter analysis of a mouse anion exchanger 3
(AE3) gene.";
DNA Seq. 13:251-255(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain cortex;
PubMed=17114649; DOI=10.1074/mcp.M600046-MCP200;
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,
Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in
naive and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-170 AND
SER-198, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Brain, and Heart;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-294, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
-!- FUNCTION: Plasma membrane anion exchange protein.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=FL-AE3;
IsoId=P16283-1; Sequence=Displayed;
Name=311-AE3;
IsoId=P16283-2; Sequence=VSP_000464, VSP_000465;
Name=14-AE3;
IsoId=P16283-3; Sequence=VSP_000466, VSP_000467;
-!- TISSUE SPECIFICITY: Neuronal.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; M28383; AAA37184.1; -; mRNA.
EMBL; S69314; AAB30140.1; -; mRNA.
EMBL; AF294651; AAG25582.1; -; Genomic_DNA.
EMBL; CH466548; EDL00426.1; -; Genomic_DNA.
CCDS; CCDS15080.1; -. [P16283-1]
PIR; A33638; A33638.
RefSeq; NP_033234.2; NM_009208.3. [P16283-1]
RefSeq; XP_006496512.1; XM_006496449.3. [P16283-1]
RefSeq; XP_006496513.1; XM_006496450.3. [P16283-1]
RefSeq; XP_006496514.1; XM_006496451.3. [P16283-1]
RefSeq; XP_006496515.1; XM_006496452.3. [P16283-1]
RefSeq; XP_006496516.1; XM_006496453.2. [P16283-1]
UniGene; Mm.5053; -.
ProteinModelPortal; P16283; -.
SMR; P16283; -.
IntAct; P16283; 1.
MINT; MINT-4996490; -.
STRING; 10090.ENSMUSP00000116747; -.
iPTMnet; P16283; -.
PhosphoSitePlus; P16283; -.
MaxQB; P16283; -.
PaxDb; P16283; -.
PeptideAtlas; P16283; -.
PRIDE; P16283; -.
Ensembl; ENSMUST00000124341; ENSMUSP00000116747; ENSMUSG00000006576. [P16283-1]
GeneID; 20536; -.
KEGG; mmu:20536; -.
UCSC; uc007bpv.2; mouse. [P16283-1]
CTD; 6508; -.
MGI; MGI:109350; Slc4a3.
eggNOG; KOG1172; Eukaryota.
eggNOG; ENOG410XPHD; LUCA.
GeneTree; ENSGT00760000119021; -.
HOGENOM; HOG000280683; -.
HOVERGEN; HBG004326; -.
InParanoid; P16283; -.
KO; K13856; -.
OMA; PAPLWPH; -.
OrthoDB; EOG091G01FT; -.
PhylomeDB; P16283; -.
TreeFam; TF313630; -.
Reactome; R-MMU-425381; Bicarbonate transporters.
ChiTaRS; Slc4a3; mouse.
PRO; PR:P16283; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000006576; -.
ExpressionAtlas; P16283; baseline and differential.
Genevisible; P16283; MM.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0015301; F:anion:anion antiporter activity; IDA:MGI.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
GO; GO:0008510; F:sodium:bicarbonate symporter activity; IBA:GO_Central.
GO; GO:0051453; P:regulation of intracellular pH; IDA:MGI.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR001717; Anion_exchange.
InterPro; IPR002979; Anion_exchange_3.
InterPro; IPR018241; Anion_exchange_CS.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
PANTHER; PTHR11453:SF15; PTHR11453:SF15; 1.
Pfam; PF07565; Band_3_cyto; 1.
Pfam; PF00955; HCO3_cotransp; 2.
PRINTS; PR00165; ANIONEXCHNGR.
PRINTS; PR01189; ANIONEXHNGR3.
PRINTS; PR01231; HCO3TRNSPORT.
SUPFAM; SSF55804; SSF55804; 2.
TIGRFAMs; TIGR00834; ae; 1.
PROSITE; PS00219; ANION_EXCHANGER_1; 1.
PROSITE; PS00220; ANION_EXCHANGER_2; 1.
1: Evidence at protein level;
Alternative splicing; Anion exchange; Antiport; Complete proteome;
Glycoprotein; Ion transport; Lipoprotein; Membrane; Methylation;
Palmitate; Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 1227 Anion exchange protein 3.
/FTId=PRO_0000079220.
TOPO_DOM 1 707 Cytoplasmic.
TRANSMEM 708 730 Helical. {ECO:0000255}.
TRANSMEM 736 773 Helical. {ECO:0000255}.
TRANSMEM 793 815 Helical. {ECO:0000255}.
TRANSMEM 825 846 Helical. {ECO:0000255}.
TRANSMEM 888 905 Helical. {ECO:0000255}.
TOPO_DOM 906 920 Cytoplasmic. {ECO:0000255}.
TRANSMEM 921 941 Helical. {ECO:0000255}.
TRANSMEM 975 997 Helical. {ECO:0000255}.
TRANSMEM 1023 1044 Helical. {ECO:0000255}.
TRANSMEM 1078 1123 Helical. {ECO:0000255}.
TRANSMEM 1150 1186 Helical. {ECO:0000255}.
REGION 708 1227 Membrane (anion exchange).
COMPBIAS 135 145 Poly-Glu.
MOD_RES 167 167 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 170 170 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 175 175 Phosphoserine.
{ECO:0000250|UniProtKB:P23348}.
MOD_RES 198 198 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 294 294 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
LIPID 1160 1160 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 868 868 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 381 391 AALLDLEQTTL -> RAFWAGNESLL (in isoform
311-AE3). {ECO:0000305}.
/FTId=VSP_000464.
VAR_SEQ 392 1227 Missing (in isoform 311-AE3).
{ECO:0000305}.
/FTId=VSP_000465.
VAR_SEQ 487 503 KPLHMPGGDGHRGKSLK -> FCVLRSPSPCLGETVTEGKA
(in isoform 14-AE3). {ECO:0000305}.
/FTId=VSP_000466.
VAR_SEQ 504 1227 Missing (in isoform 14-AE3).
{ECO:0000305}.
/FTId=VSP_000467.
CONFLICT 530 530 A -> G (in Ref. 1; AAA37184).
{ECO:0000305}.
CONFLICT 812 812 S -> T (in Ref. 1; AAA37184).
{ECO:0000305}.
CONFLICT 1150 1151 MH -> ID (in Ref. 1; AAA37184).
{ECO:0000305}.
CONFLICT 1187 1188 RR -> SG (in Ref. 1; AAA37184).
{ECO:0000305}.
SEQUENCE 1227 AA; 135373 MW; 68BC64B72E5FDC55 CRC64;
MANGVIPPPG GASPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL ISKTPAWDPE
KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRPPP TSARHTRRKR KKEKTSAPPS
EGTPPIQEEG GAGAEEEEEE EEEEEGESEA EPVEPLPPGP PQKAKFSIGS DEDDSPGLPV
KAPCAKALPS VGLQSDQSPQ RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA
LGNPGPEQRV PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV EEETERWGKP
HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE TMIVSDQIRP EDRASVLRTL
LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG NHHPTPSHGP DGAVPTMADD QGEPAPLWPH
DPDAKEKPLH MPGGDGHRGK SLKLLEKIPE DAEATVVLVG CVPFLEQPAA AFVRLSEAVL
LESVLEVPVP VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG YAAPGKELSL
EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR DALHSQCVAA VLFIYFAALS
PAITFGGLLG EKTEGLMGVS ELIVSTAVLG VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF
CRAQDLEYLT GRVWVGLWLV VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH
KLYKVFTEHP LLPFYPPDEA LETGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL
IAFFLRKFRN SRFLGGKARR IIGDFGIPIS ILVMVLVDYS ITDTYTQKLT VPTGLSVTSP
HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ ITALIVSQKA RRLLKGSGFH
LDLLLIGSLG GLCGLFGLPW LTAATVRSVT HVNALTVMRT AIAPGDKPQI QEVREQRVTG
VLIASLVGLS IVMGAVLRRI PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP
YVTKVKTWRM HLFTCIQLGC IALLWVVKST AASLAFPFLL LLTVPLRRCL LPRLFQDREL
QALDSEDAEP NFDEDGQDEY NELHMPV


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