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Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Solute carrier family 4 member 9)

 B3A4_RAT                Reviewed;         953 AA.
Q8K4V2;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
22-NOV-2017, entry version 102.
RecName: Full=Anion exchange protein 4;
Short=AE 4;
Short=Anion exchanger 4;
AltName: Full=Solute carrier family 4 member 9;
Name=Slc4a9; Synonyms=Ae4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND CHARACTERIZATION.
TISSUE=Kidney;
PubMed=12225984; DOI=10.1152/ajpcell.00512.2001;
Ko S.B.H., Luo X., Hager H., Rojek A., Choi J.Y., Licht C., Suzuki M.,
Muallem S., Nielsen S., Ishibashi K.;
"AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral
membrane of the renal CCD and the SMG duct.";
Am. J. Physiol. 283:C1206-C1218(2002).
-!- FUNCTION: Probable apical anion exchanger of the alpha-
intercalated cells of kidney. May participate in HCO3(-)
absorption. {ECO:0000269|PubMed:12225984}.
-!- SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass
membrane protein. Note=In contrast to the rabbit ortholog, it is
present on basolateral membrane of cortical collecting duct kidney
cells.
-!- TISSUE SPECIFICITY: Expressed in kidney and gastrointestinal
tract. In kidney, it is highly expressed in the cortex, expressed
at intermediate level in the outer medulla and not expressed in
the inner medulla. It is expressed in the cecum, while it is
absent in other segments of gastrointestinal tract.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; AB024339; BAC10662.1; -; mRNA.
RefSeq; NP_690921.1; NM_152938.1.
UniGene; Rn.47849; -.
ProteinModelPortal; Q8K4V2; -.
STRING; 10116.ENSRNOP00000025137; -.
iPTMnet; Q8K4V2; -.
PhosphoSitePlus; Q8K4V2; -.
PaxDb; Q8K4V2; -.
GeneID; 266612; -.
KEGG; rno:266612; -.
UCSC; RGD:628811; rat.
CTD; 83697; -.
RGD; 628811; Slc4a9.
eggNOG; KOG1172; Eukaryota.
eggNOG; ENOG410XPHD; LUCA.
HOGENOM; HOG000280684; -.
HOVERGEN; HBG004326; -.
InParanoid; Q8K4V2; -.
KO; K13860; -.
PhylomeDB; Q8K4V2; -.
PRO; PR:Q8K4V2; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0045177; C:apical part of cell; ISO:RGD.
GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0015301; F:anion:anion antiporter activity; IDA:RGD.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
GO; GO:0008510; F:sodium:bicarbonate symporter activity; IBA:GO_Central.
GO; GO:0006820; P:anion transport; IDA:RGD.
GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR003024; Na/HCO3_transpt.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
Pfam; PF07565; Band_3_cyto; 2.
Pfam; PF00955; HCO3_cotransp; 1.
PRINTS; PR01231; HCO3TRNSPORT.
PRINTS; PR01232; NAHCO3TRSPRT.
SUPFAM; SSF55804; SSF55804; 1.
TIGRFAMs; TIGR00834; ae; 1.
1: Evidence at protein level;
Anion exchange; Antiport; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Ion transport; Membrane;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 953 Anion exchange protein 4.
/FTId=PRO_0000079225.
TOPO_DOM 1 384 Cytoplasmic. {ECO:0000255}.
TRANSMEM 385 405 Helical. {ECO:0000255}.
TRANSMEM 413 433 Helical. {ECO:0000255}.
TRANSMEM 435 455 Helical. {ECO:0000255}.
TRANSMEM 470 490 Helical. {ECO:0000255}.
TRANSMEM 501 521 Helical. {ECO:0000255}.
TOPO_DOM 522 593 Extracellular. {ECO:0000255}.
TRANSMEM 594 614 Helical. {ECO:0000255}.
TRANSMEM 635 655 Helical. {ECO:0000255}.
TOPO_DOM 656 681 Cytoplasmic. {ECO:0000255}.
TRANSMEM 682 702 Helical. {ECO:0000255}.
TRANSMEM 728 748 Helical. {ECO:0000255}.
TRANSMEM 785 805 Helical. {ECO:0000255}.
TRANSMEM 843 863 Helical. {ECO:0000255}.
TRANSMEM 869 889 Helical. {ECO:0000255}.
REGION 385 953 Membrane (anion exchange).
CARBOHYD 546 546 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 570 570 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 536 538 {ECO:0000250|UniProtKB:Q9Y6R1}.
DISULFID 579 591 {ECO:0000250|UniProtKB:Q9Y6R1}.
SEQUENCE 953 AA; 105320 MW; 625A98A969821F85 CRC64;
MKLPGQEDFE GSDAHENVCS EQLDGDLGPG SGLDGPSDID NGKAQGCKDP LLFIQLNELL
GWPQALEWRE TGRWLLFEEK LDIGAGRWSA PHVPTLALPS LQKLRGLLAE GIVLLDCPAR
SLLELVEQVV RVESLSPELR GQLQALLLQR PQHHIQTTGI RPCRRSNAFR KASRDEDTLL
KHQNPLRQKL PPGAEAAAVL AGELGFLEQP LAAFVRLQNP VVLEPLTEVV LPSRFFCLLL
GPSTLGRSYH ETGRAAAVLL SDPQFQWSVR RASNLHDLLA ALDAFLQEVT ALPPGRWDRT
ARIPPPKCLP SQHKRFPSKL QEVTSLSRQS AALAENKHHH GPHTPIPELQ RTGRLFGGLV
QDVRRKACWY PSDFLDALHP QCFSAVLYIY LATVTNAITF GGLLGDATEG AQGVLESFLG
TAVAGATFCL MAGQPLTILS STGPVLVFER LLFSFSRDYS LDYLPFRLWV GIWVATFCLA
LVATEASLLV RYFTRFTEEG FCALISLIFI YDAVGKMLNL IRAYPIQRPG SPAYSCFCQY
PGTGGNASEF DSTMFKDTED VLNVHPGLVN ASFLPPSECI RQGGYPRGPS CHTVPDIAFF
SLLLFFTSFL CAIALKHVKN SRLFPSVVRK VFSDFSSVLA ILLGCGLDAF LGLATPKLLV
PTEFKPTLPG RGWLVSPFGA NPWWLSVAAA LPALLLSILI FMDQQITAVI LNRAEYRLQK
GAGFHLDLFC VAVLMLFTSA LGLPWYVSAT VISLAHMDSL RRESKACVPG EDPNFLGIRE
QRLTGLVVFI LTGVSIFLAP VLKFIPMPVL YGIFLYMGVA ALSSMQFMKR VQLLLMPRKH
QPDVLLLRHV PLIRVHLFTA IQLACLGLLW VIKSTPAAIV FPLMLLGLVA VRKALEWIFS
PQELLWLDEL MPEEEKTIPE NRPEPEHLFS GNDSENSELM YQPKAPEINI SVN


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