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Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Solute carrier family 4 member 9)

 B3A4_RABIT              Reviewed;         955 AA.
Q9GKY1; Q9GKY2;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
28-MAR-2003, sequence version 2.
10-MAY-2017, entry version 95.
RecName: Full=Anion exchange protein 4;
Short=AE 4;
Short=Anion exchanger 4;
AltName: Full=Solute carrier family 4 member 9;
Name=SLC4A9; Synonyms=AE4;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, AND
CHARACTERIZATION.
TISSUE=Kidney;
PubMed=11102437; DOI=10.1074/jbc.M004513200;
Tsuganezawa H., Kobayashi K., Iyori M., Araki T., Koizumi A.,
Watanabe S., Kaneko A., Fukao T., Monkawa T., Yoshida T., Kim D.K.,
Kanai Y., Endou H., Hayashi M., Saruta T.;
"A new member of the HCO3-transporter superfamily is an apical anion
exchanger of beta-intercalated cells in the kidney.";
J. Biol. Chem. 276:8180-8189(2001).
-!- FUNCTION: Probable apical anion exchanger of the beta-intercalated
cells of kidney. May participate in HCO3(-) secretion.
{ECO:0000269|PubMed:11102437}.
-!- SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane
protein. Note=In contrast to the rat ortholog, it is present on
apical membrane of cortical kidney cells.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=AE4a;
IsoId=Q9GKY1-1; Sequence=Displayed;
Name=2; Synonyms=AE4b;
IsoId=Q9GKY1-2; Sequence=VSP_007088;
-!- TISSUE SPECIFICITY: Highly expressed in kidney. Expressed in
certain types of cells in the kidney cortex.
-!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
{ECO:0000305}.
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EMBL; AB038263; BAB18935.1; -; mRNA.
EMBL; AB038264; BAB18936.1; -; mRNA.
RefSeq; NP_001075474.1; NM_001082005.1. [Q9GKY1-1]
UniGene; Ocu.2536; -.
ProteinModelPortal; Q9GKY1; -.
STRING; 9986.ENSOCUP00000013683; -.
TCDB; 2.A.31.2.5; the anion exchanger (ae) family.
GeneID; 100008621; -.
KEGG; ocu:100008621; -.
CTD; 83697; -.
eggNOG; KOG1172; Eukaryota.
eggNOG; ENOG410XPHD; LUCA.
HOGENOM; HOG000280684; -.
HOVERGEN; HBG004326; -.
InParanoid; Q9GKY1; -.
KO; K13860; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015301; F:anion:anion antiporter activity; IEA:UniProtKB-KW.
GO; GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro.
Gene3D; 3.40.930.10; -; 1.
InterPro; IPR013769; Band3_cytoplasmic_dom.
InterPro; IPR011531; HCO3_transpt_C.
InterPro; IPR003020; HCO3_transpt_euk.
InterPro; IPR003024; Na/HCO3_transpt.
InterPro; IPR016152; PTrfase/Anion_transptr.
PANTHER; PTHR11453; PTHR11453; 1.
Pfam; PF07565; Band_3_cyto; 2.
Pfam; PF00955; HCO3_cotransp; 1.
PRINTS; PR01231; HCO3TRNSPORT.
PRINTS; PR01232; NAHCO3TRSPRT.
SUPFAM; SSF55804; SSF55804; 1.
TIGRFAMs; TIGR00834; ae; 1.
1: Evidence at protein level;
Alternative splicing; Anion exchange; Antiport; Cell membrane;
Complete proteome; Disulfide bond; Glycoprotein; Ion transport;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 955 Anion exchange protein 4.
/FTId=PRO_0000079224.
TOPO_DOM 1 386 Cytoplasmic. {ECO:0000255}.
TRANSMEM 387 407 Helical. {ECO:0000255}.
TRANSMEM 415 435 Helical. {ECO:0000255}.
TRANSMEM 438 458 Helical. {ECO:0000255}.
TRANSMEM 472 492 Helical. {ECO:0000255}.
TRANSMEM 503 523 Helical. {ECO:0000255}.
TOPO_DOM 524 595 Extracellular. {ECO:0000255}.
TRANSMEM 596 616 Helical. {ECO:0000255}.
TRANSMEM 637 657 Helical. {ECO:0000255}.
TOPO_DOM 658 683 Cytoplasmic. {ECO:0000255}.
TRANSMEM 684 704 Helical. {ECO:0000255}.
TRANSMEM 730 750 Helical. {ECO:0000255}.
TRANSMEM 785 804 Helical. {ECO:0000255}.
TRANSMEM 847 867 Helical. {ECO:0000255}.
TRANSMEM 871 891 Helical. {ECO:0000255}.
REGION 387 955 Membrane (anion exchange).
CARBOHYD 548 548 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 572 572 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 538 540 {ECO:0000250|UniProtKB:Q9Y6R1}.
DISULFID 581 593 {ECO:0000250|UniProtKB:Q9Y6R1}.
VAR_SEQ 317 332 Missing (in isoform 2).
{ECO:0000303|PubMed:11102437}.
/FTId=VSP_007088.
SEQUENCE 955 AA; 105033 MW; 04E595A2BFC415B7 CRC64;
MKLPGQEELE AACACENVPV GQLDSGPSSG PCPDDPSDTG SRELGPPEDP PLFLQLNELL
GWPQTLEWRE MGRWVLFEEK LEVDAGRWSA PHVPTLALPS LQNLRSLLAE GLVLLDCPAQ
NLLELVEQVT RVESLSPELR GQLQALLLQR PQHHTQTTGS RPCWGPAQSR KAAHNKEAPM
QQQCQSPLRQ KLPPGAEAGA VLAGELGFLA QPLAAFVRLR DPVWLGPLTE VPLPSRFFCL
LLGPPMLGKG YHELGRAAAV LLSDPHFQWS VRRASNLHDL LTALDAFLEE VTVLPPGRWD
PTARIPPPRC LPSRHKRPPL HLQKVKGLSV PHRTQAEDRH RNGPLAPSPE LQRTGRLFGG
LVQDVRRKAS WYPSDFSDAL HPQCVSAVLY IYLATVTNAI TFGGLLGDAT DGAQGVLESL
LGTAVAGAAF CLMAGQPLTV LSSTGPVLVF ERLLFAFCRD YSLDYLPFRL WVGIWVAVFC
LALVATEASV LVRYFTRFTE EGFCALISLI FIYDAVGKML NLAHAYPIQR PGSLAYGCLC
QFPGPGGNES QWTRPRPQSR DDLLSVDLGL VNASLLPPHE CVQQGGYPRG PGCHTVPDIA
FFSLLLFLTS FLFAIALKHM KTSRFFPSVV RKVLSDFSSI LAILLGCGLD ALLGLAMPKL
MVPREFKPTL PGRGWLVPPF GANPWWLSVA AALPALLLSI LIFMDQQITA VILNRVEYRL
RKGAGFHLDL FCVALLMLLT SVLGLPWYVS ATVLSLAHMD SLRRESRACA PGEPHSFLGI
REQRLTGLAV FTLTGVSIFL APVLKFIPMP VLYGIFLYMG VAALSSIQFM KRVQLMLMPA
KHQPDLLLLR HVPLSRVHLF TAIQLACLGL LWIIKSTPAA IIFPLMLLGL VGVRKALEWV
FSPQELLWLD ELMPEEERNV PEKGLEPGHS FSGSDSEDSE LMYQPKAPEI NISVN


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