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Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)

 ASZ1_CARPS              Reviewed;         475 AA.
Q2QLC6;
07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
24-JAN-2006, sequence version 1.
23-MAY-2018, entry version 52.
RecName: Full=Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1;
AltName: Full=Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein;
Name=ASZ1; Synonyms=GASZ;
Carollia perspicillata (Seba's short-tailed bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
Phyllostomidae; Carolliinae; Carollia.
NCBI_TaxID=40233;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Antonellis A., Ayele K., Benjamin B., Blakesley R.W., Boakye A.,
Bouffard G.G., Brinkley C., Brooks S., Chu G., Coleman H., Engle J.,
Gestole M., Greene A., Guan X., Gupta J., Haghighi P., Han J.,
Hansen N., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Kwong P.,
Laric P., Larson S., Lee-Lin S.-Q., Legaspi R., Madden M.,
Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B.,
McDowell J., Mojidi H.A., Mullikin J.C., Oestreicher J.S., Park M.,
Portnoy M.E., Prasad A., Puri O., Reddix-Dugue N., Schandler K.,
Schueler M.G., Sison C., Stantripop S., Stephen E., Taye A.,
Thomas J.W., Thomas P.J., Tsipouri V., Ung L., Vogt J.L.,
Wetherby K.D., Young A., Green E.D.;
"NISC comparative sequencing initiative.";
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays a central role during spermatogenesis by
repressing transposable elements and preventing their
mobilization, which is essential for the germline integrity. Acts
via the piRNA metabolic process, which mediates the repression of
transposable elements during meiosis by forming complexes composed
of piRNAs and Piwi proteins and governs the methylation and
subsequent repression of transposons. Its association with pi-
bodies suggests a participation in the primary piRNAs metabolic
process. Required prior to the pachytene stage to facilitate the
production of multiple types of piRNAs, including those associated
with repeats involved in the regulation of retrotransposons. May
act by mediating protein-protein interactions during germ cell
maturation (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Component of
the meiotic nuage, also named P granule, a germ-cell-specific
organelle required to repress transposon activity during meiosis.
Specifically localizes to pi-bodies, a subset of the nuage which
contains primary piRNAs (By similarity). {ECO:0000250}.
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EMBL; DP000018; ABB89783.1; -; Genomic_DNA.
ProteinModelPortal; Q2QLC6; -.
SMR; Q2QLC6; -.
PRIDE; Q2QLC6; -.
HOVERGEN; HBG050599; -.
GO; GO:0071546; C:pi-body; ISS:UniProtKB.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
GO; GO:0007140; P:male meiotic nuclear division; ISS:UniProtKB.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0034587; P:piRNA metabolic process; ISS:UniProtKB.
GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
CDD; cd00204; ANK; 2.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR001660; SAM.
InterPro; IPR013761; SAM/pointed_sf.
Pfam; PF12796; Ank_2; 1.
Pfam; PF07647; SAM_2; 1.
PRINTS; PR01415; ANKYRIN.
SMART; SM00248; ANK; 5.
SUPFAM; SSF47769; SSF47769; 1.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 3.
3: Inferred from homology;
ANK repeat; Cytoplasm; Developmental protein; Differentiation;
Meiosis; Phosphoprotein; Repeat; RNA-mediated gene silencing;
Spermatogenesis.
CHAIN 1 475 Ankyrin repeat, SAM and basic leucine
zipper domain-containing protein 1.
/FTId=PRO_0000226355.
REPEAT 45 74 ANK 1.
REPEAT 78 107 ANK 2.
REPEAT 110 144 ANK 3.
REPEAT 148 177 ANK 4.
REPEAT 181 210 ANK 5.
REPEAT 214 243 ANK 6.
DOMAIN 272 334 SAM.
MOD_RES 17 17 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD46}.
MOD_RES 18 18 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD46}.
MOD_RES 20 20 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VD46}.
SEQUENCE 475 AA; 53105 MW; A91A9E3ADA3D5578 CRC64;
MAAGRLRGLA VAGGGESSES DDDGWEIGYL DRASQKLKGV LPTEEKNETF KKALTTGDIS
LVQELLNSGI SVDSSFRYGW TPLMYAASVS NVELVRVLLD RGANANFDKD KQTILITTCS
SRGSEEQIVK CVELLLSRNA DPNVPCRRLM TPIMYAARDG HPQVVALLVA HGAEVNTQDE
SGYTALTWAA RQGHKNVVLK LLELGADKML QTKDGNIPSE IAKRYKHLEI FSLLSLSLNP
LKGKLQQQTK EETICKLLAT DSDKEKDHIF SSYTAFGDLE VFLHGLGLEH MTDLLKERDI
TLRHLLTMRK DEFTKNGITS RDQQKILAAL KELDVEEIKF GELPEVAKLE ISGDEFLNFL
LKLNKQCGHL ITAVENIITE LPVNSHKIVL EWASPQSFTS VCEELVSNVE DLSEEVCKLK
DLIKKLQNER ENDPTHMPLV EEVSTWNSRM LKRTAITVCG FGFLLFICKL TFLRK


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