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Ankyrin repeat domain-containing protein 1 (Cardiac adriamycin-responsive protein) (Cardiac ankyrin repeat protein)

 ANKR1_RAT               Reviewed;         319 AA.
Q8R560; Q9Z1F0;
27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
23-MAY-2018, entry version 107.
RecName: Full=Ankyrin repeat domain-containing protein 1;
AltName: Full=Cardiac adriamycin-responsive protein;
AltName: Full=Cardiac ankyrin repeat protein;
Name=Ankrd1; Synonyms=Carp;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH YBX1, SUBCELLULAR
LOCATION, FUNCTION, AND TISSUE SPECIFICITY.
TISSUE=Heart;
PubMed=9043061;
Zou Y., Evans S., Chen J., Kuo H.-C., Harvey R.P., Chien K.R.;
"CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5
homeobox gene pathway.";
Development 124:793-804(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA], INDUCTION BY DOXORUBICIN, SUBCELLULAR
LOCATION, AND FUNCTION.
STRAIN=Sprague-Dawley;
PubMed=9278441; DOI=10.1074/jbc.272.36.22800;
Jeyaseelan R., Poizat C., Baker R.K., Abdishoo S., Isterabadi L.B.,
Lyons G.E., Kedes L.;
"A novel cardiac-restricted target for doxorubicin. CARP, a nuclear
modulator of gene expression in cardiac progenitor cells and
cardiomyocytes.";
J. Biol. Chem. 272:22800-22808(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: May play an important role in endothelial cell
activation. May act as a nuclear transcription factor that
negatively regulates the expression of cardiac genes.
{ECO:0000269|PubMed:9043061, ECO:0000269|PubMed:9278441}.
-!- SUBUNIT: Interacts with TTN/titin (By similarity). Interacts with
YBX1. {ECO:0000250, ECO:0000269|PubMed:9043061}.
-!- INTERACTION:
Q5VU43-11:PDE4DIP (xeno); NbExp=2; IntAct=EBI-10817505, EBI-10769071;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9043061,
ECO:0000269|PubMed:9278441}.
-!- TISSUE SPECIFICITY: Expressed in heart, cardiac muscle.
{ECO:0000269|PubMed:9043061}.
-!- INDUCTION: Down-regulated by doxorubicin (adriamycin), in vitro.
{ECO:0000269|PubMed:9278441}.
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EMBL; L81174; AAL77519.1; -; mRNA.
EMBL; U50736; AAD10401.1; -; mRNA.
EMBL; BC072699; AAH72699.1; -; mRNA.
RefSeq; NP_037352.1; NM_013220.1.
UniGene; Rn.3789; -.
ProteinModelPortal; Q8R560; -.
SMR; Q8R560; -.
IntAct; Q8R560; 1.
STRING; 10116.ENSRNOP00000025258; -.
PaxDb; Q8R560; -.
PRIDE; Q8R560; -.
Ensembl; ENSRNOT00000025258; ENSRNOP00000025258; ENSRNOG00000018598.
GeneID; 27064; -.
KEGG; rno:27064; -.
UCSC; RGD:61989; rat.
CTD; 27063; -.
RGD; 61989; Ankrd1.
eggNOG; KOG0504; Eukaryota.
eggNOG; COG0666; LUCA.
GeneTree; ENSGT00910000144039; -.
HOGENOM; HOG000236321; -.
HOVERGEN; HBG071561; -.
InParanoid; Q8R560; -.
KO; K21433; -.
OMA; KGDPNVC; -.
OrthoDB; EOG091G0DCN; -.
PhylomeDB; Q8R560; -.
TreeFam; TF331650; -.
PRO; PR:Q8R560; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000018598; -.
Genevisible; Q8R560; RN.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
GO; GO:0031674; C:I band; IDA:BHF-UCL.
GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
GO; GO:0061629; F:RNA polymerase II sequence-specific DNA binding transcription factor binding; IBA:GO_Central.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Ensembl.
GO; GO:0031432; F:titin binding; IBA:GO_Central.
GO; GO:0003712; F:transcription cofactor activity; TAS:RGD.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0045445; P:myoblast differentiation; IBA:GO_Central.
GO; GO:2000279; P:negative regulation of DNA biosynthetic process; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; TAS:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
CDD; cd00204; ANK; 2.
Gene3D; 1.25.40.20; -; 2.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
Pfam; PF12796; Ank_2; 2.
PRINTS; PR01415; ANKYRIN.
SMART; SM00248; ANK; 4.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 4.
1: Evidence at protein level;
ANK repeat; Coiled coil; Complete proteome; Nucleus;
Reference proteome; Repeat.
CHAIN 1 319 Ankyrin repeat domain-containing protein
1.
/FTId=PRO_0000240483.
REPEAT 152 181 ANK 1.
REPEAT 185 214 ANK 2.
REPEAT 218 247 ANK 3.
REPEAT 251 280 ANK 4.
REPEAT 284 315 ANK 5.
COILED 55 89 {ECO:0000255}.
CONFLICT 287 287 T -> I (in Ref. 2; AAD10401).
{ECO:0000305}.
SEQUENCE 319 AA; 36064 MW; E760BF7BFD6049E0 CRC64;
MMVFRVEELV TGKKNSNGSS GEFLPGEFRN GEYEAAVALE KQEDLKTLPA NSVNLGEEQR
KSEKVREAEL KKKKLEQRSK LENLEDLEII VQLKKRKKYK KTKVPVVKEP EPEIITEPVD
VPRFLKAALE NKLPVVEKFL SDKNSPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE
FRDMLESTAI HWACRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA
CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LMTFGADLNV KNCAGKTPMD LVLHWQNGTK
AIFDSLKENA YKNSRIATF


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