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Annexin A2 (Annexin-2)

 ANXA2_PONAB             Reviewed;         339 AA.
Q5R5A0;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
25-OCT-2017, entry version 95.
RecName: Full=Annexin A2;
AltName: Full=Annexin-2;
Name=ANXA2; Synonyms=ANX2;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Calcium-regulated membrane-binding protein whose
affinity for calcium is greatly enhanced by anionic phospholipids.
It binds two calcium ions with high affinity. May be involved in
heat-stress response. Inhibits PCSK9-enhanced LDLR degradation,
probably reduces PCSK9 protein levels via a translational
mechanism but also competes with LDLR for binding with PCSK9.
{ECO:0000250|UniProtKB:P07355}.
-!- SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11
and 2 heavy chains of ANXA2/p36 (By similarity). Interacts with
ATP1B1 (By similarity). Interacts with DYSF (By similarity).
Interacts with COCH. Interacts (via repeat Annexin 1) with PCSK9
(via the C-terminal domain); the interaction inhibits the
degradation of LDLR. Interacts with CEACAM1 (via the cytoplasmic
domain); this interaction is regulated by phosphorylation of
CEACAM1 (By similarity). {ECO:0000250|UniProtKB:A2SW69,
ECO:0000250|UniProtKB:P07355, ECO:0000250|UniProtKB:P07356,
ECO:0000250|UniProtKB:Q6TEQ7}.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix, basement membrane. Note=In the lamina beneath the plasma
membrane. {ECO:0000250}.
-!- DOMAIN: A pair of annexin repeats may form one binding site for
calcium and phospholipid.
-!- PTM: ISGylated. {ECO:0000250}.
-!- MISCELLANEOUS: It may cross-link plasma membrane phospholipids
with actin and the cytoskeleton and be involved with exocytosis.
-!- SIMILARITY: Belongs to the annexin family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Red velvet - Issue 86
of September 2007;
URL="http://web.expasy.org/spotlight/back_issues/086";
-----------------------------------------------------------------------
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EMBL; CR860964; CAH93066.1; -; mRNA.
RefSeq; NP_001126816.1; NM_001133344.1.
UniGene; Pab.8142; -.
ProteinModelPortal; Q5R5A0; -.
SMR; Q5R5A0; -.
STRING; 9601.ENSPPYP00000007399; -.
PRIDE; Q5R5A0; -.
Ensembl; ENSPPYT00000007703; ENSPPYP00000007399; ENSPPYG00000006526.
GeneID; 100173821; -.
KEGG; pon:100173821; -.
CTD; 302; -.
eggNOG; KOG0819; Eukaryota.
eggNOG; ENOG410XPUN; LUCA.
GeneTree; ENSGT00760000118972; -.
HOVERGEN; HBG061815; -.
InParanoid; Q5R5A0; -.
KO; K17092; -.
OMA; FIQQDTK; -.
OrthoDB; EOG091G0H6H; -.
TreeFam; TF105452; -.
Proteomes; UP000001595; Chromosome 15.
GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005913; C:cell-cell adherens junction; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005769; C:early endosome; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl.
GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0030496; C:midbody; IEA:Ensembl.
GO; GO:0035749; C:myelin sheath adaxonal region; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:1990667; C:PCSK9-AnxA2 complex; IEA:Ensembl.
GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
GO; GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl.
GO; GO:0098641; F:cadherin binding involved in cell-cell adhesion; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0030546; F:receptor activator activity; IEA:Ensembl.
GO; GO:0003723; F:RNA binding; IEA:Ensembl.
GO; GO:0044548; F:S100 protein binding; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0052362; P:catabolism by host of symbiont protein; IEA:Ensembl.
GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
GO; GO:0042730; P:fibrinolysis; IEA:Ensembl.
GO; GO:0001765; P:membrane raft assembly; IEA:Ensembl.
GO; GO:0052405; P:negative regulation by host of symbiont molecular function; IEA:Ensembl.
GO; GO:0044147; P:negative regulation of development of symbiont involved in interaction with host; IEA:Ensembl.
GO; GO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IEA:Ensembl.
GO; GO:0036035; P:osteoclast development; IEA:Ensembl.
GO; GO:1905581; P:positive regulation of low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:1905597; P:positive regulation of low-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:1905599; P:positive regulation of low-density lipoprotein receptor activity; IEA:Ensembl.
GO; GO:0001921; P:positive regulation of receptor recycling; IEA:Ensembl.
GO; GO:1905602; P:positive regulation of receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
GO; GO:0044090; P:positive regulation of vacuole organization; IEA:Ensembl.
GO; GO:0031340; P:positive regulation of vesicle fusion; IEA:Ensembl.
GO; GO:0051290; P:protein heterotetramerization; IEA:Ensembl.
GO; GO:0006900; P:vesicle budding from membrane; IEA:Ensembl.
Gene3D; 1.10.220.10; -; 4.
InterPro; IPR001464; Annexin.
InterPro; IPR018502; Annexin_repeat.
InterPro; IPR018252; Annexin_repeat_CS.
InterPro; IPR037104; Annexin_sf.
InterPro; IPR002389; ANX2.
PANTHER; PTHR10502:SF18; PTHR10502:SF18; 1.
Pfam; PF00191; Annexin; 4.
PRINTS; PR00196; ANNEXIN.
PRINTS; PR00198; ANNEXINII.
SMART; SM00335; ANX; 4.
PROSITE; PS00223; ANNEXIN; 4.
2: Evidence at transcript level;
Acetylation; Annexin; Basement membrane; Calcium;
Calcium/phospholipid-binding; Complete proteome; Extracellular matrix;
Isopeptide bond; Phosphoprotein; Reference proteome; Repeat; Secreted;
Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P04272}.
CHAIN 2 339 Annexin A2.
/FTId=PRO_0000288686.
REPEAT 42 102 Annexin 1.
REPEAT 114 174 Annexin 2.
REPEAT 199 259 Annexin 3.
REPEAT 274 334 Annexin 4.
REGION 2 24 S100A10-binding site. {ECO:0000255}.
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:P04272}.
MOD_RES 24 24 Phosphotyrosine; by SRC.
{ECO:0000250|UniProtKB:P07355}.
MOD_RES 26 26 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P07355}.
MOD_RES 49 49 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P07356}.
MOD_RES 152 152 N6-acetyllysine.
{ECO:0000250|UniProtKB:P07356}.
MOD_RES 184 184 Phosphoserine.
{ECO:0000250|UniProtKB:P07355}.
MOD_RES 199 199 Phosphotyrosine.
{ECO:0000250|UniProtKB:P07356}.
MOD_RES 227 227 N6-acetyllysine.
{ECO:0000250|UniProtKB:P07356}.
CROSSLNK 49 49 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1);
alternate.
{ECO:0000250|UniProtKB:P07355}.
CROSSLNK 49 49 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:P07355}.
SEQUENCE 339 AA; 38604 MW; 5126E1337A0CBEA1 CRC64;
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL
TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA
EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM
LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD


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