Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)

 ANXA4_BOVIN             Reviewed;         319 AA.
P13214; Q3SYU5;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
25-OCT-2017, entry version 148.
RecName: Full=Annexin A4;
AltName: Full=35-beta calcimedin;
AltName: Full=Annexin IV;
AltName: Full=Annexin-4;
AltName: Full=Carbohydrate-binding protein p33/p41;
AltName: Full=Chromobindin-4;
AltName: Full=Endonexin I;
AltName: Full=Lipocortin IV;
AltName: Full=P32.5;
AltName: Full=PP4-X;
AltName: Full=Placental anticoagulant protein II;
Short=PAP-II;
AltName: Full=Protein II;
Name=ANXA4; Synonyms=ANX4;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=2847715; DOI=10.1016/S0006-291X(88)80893-3;
Hamman H.C., Gaffey L.C., Lynch K.R., Creutz C.E.;
"Cloning and characterization of a cDNA encoding bovine endonexin
(chromobindin 4).";
Biochem. Biophys. Res. Commun. 156:660-667(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=8631806; DOI=10.1074/jbc.271.13.7679;
Kojima K., Yamamoto K., Irimura T., Osawa T., Ogawa H., Matsumoto I.;
"Characterization of carbohydrate-binding protein p33/41: relation
with annexin IV, molecular basis of the doublet forms (p33 and p41),
and modulation of the carbohydrate binding activity by
phospholipids.";
J. Biol. Chem. 271:7679-7685(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[4]
PROTEIN SEQUENCE OF 10-24; 28-48; 101-118; 194-212 AND 260-288.
TISSUE=Kidney;
PubMed=1400371;
Kojima K., Ogawa H.K., Seno N., Yamamoto K., Irimura T., Osawa T.,
Matsumoto I.;
"Carbohydrate-binding proteins in bovine kidney have consensus amino
acid sequences of annexin family proteins.";
J. Biol. Chem. 267:20536-20539(1992).
[5]
PROTEIN SEQUENCE OF 29-44; 111-118; 162-190 AND 226-235, AND
INTERACTION WITH SFTPA1.
PubMed=7492310; DOI=10.1042/bj3120175;
Sohma H., Matsushima N., Watanabe T., Hattori A., Kuroki Y., Akino T.;
"Ca(2+)-dependent binding of annexin IV to surfactant protein A and
lamellar bodies in alveolar type II cells.";
Biochem. J. 312:175-181(1995).
[6]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
Sutton R.B., Sprang S.R.;
Submitted (SEP-1995) to the PDB data bank.
[7]
X-RAY CRYSTALLOGRAPHY (3 ANGSTROMS).
PubMed=9405281; DOI=10.1042/bj3290101;
Zanotti G., Malpeli G., Gliubich F., Folli C., Stoppini M., Olivi L.,
Savoia A., Berni R.;
"Structure of the trigonal crystal form of bovine annexin IV.";
Biochem. J. 329:101-106(1998).
-!- FUNCTION: May play a role in alveolar type II cells through
interaction with the surfactant protein SFTPA1 (SP-A).
-!- SUBUNIT: Monomer. Binds to SFTPA1 in a Ca(2+)-dependent manner.
-!- DOMAIN: A pair of annexin repeats may form one binding site for
calcium and phospholipid.
-!- MISCELLANEOUS: Seems to bind one calcium ion with high affinity.
-!- SIMILARITY: Belongs to the annexin family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M22248; AAA30507.1; -; mRNA.
EMBL; X13627; CAA31954.1; -; mRNA.
EMBL; D78178; BAA11243.1; -; mRNA.
EMBL; BC103381; AAI03382.1; -; mRNA.
PIR; A31578; LUBO4.
RefSeq; NP_001001440.2; NM_001001440.2.
UniGene; Bt.38197; -.
PDB; 1ANN; X-ray; 2.30 A; A=2-319.
PDB; 1AOW; X-ray; 3.00 A; A=11-319.
PDB; 1I4A; X-ray; 2.00 A; A=2-319.
PDBsum; 1ANN; -.
PDBsum; 1AOW; -.
PDBsum; 1I4A; -.
ProteinModelPortal; P13214; -.
SMR; P13214; -.
STRING; 9913.ENSBTAP00000001463; -.
PaxDb; P13214; -.
PeptideAtlas; P13214; -.
PRIDE; P13214; -.
Ensembl; ENSBTAT00000001463; ENSBTAP00000001463; ENSBTAG00000001105.
GeneID; 281625; -.
KEGG; bta:281625; -.
CTD; 307; -.
eggNOG; KOG0819; Eukaryota.
eggNOG; ENOG410XPUN; LUCA.
GeneTree; ENSGT00760000118972; -.
HOGENOM; HOG000158803; -.
HOVERGEN; HBG061815; -.
InParanoid; P13214; -.
KO; K17093; -.
OMA; ILCGGDD; -.
OrthoDB; EOG091G0H6H; -.
TreeFam; TF105452; -.
EvolutionaryTrace; P13214; -.
Proteomes; UP000009136; Chromosome 11.
Bgee; ENSBTAG00000001105; -.
GO; GO:0016324; C:apical plasma membrane; TAS:AgBase.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0042584; C:chromaffin granule membrane; IDA:AgBase.
GO; GO:0005829; C:cytosol; IDA:AgBase.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0016020; C:membrane; IDA:AgBase.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
GO; GO:0048306; F:calcium-dependent protein binding; IPI:AgBase.
GO; GO:0030246; F:carbohydrate binding; TAS:AgBase.
GO; GO:0035374; F:chondroitin sulfate binding; IDA:AgBase.
GO; GO:0008201; F:heparin binding; IDA:AgBase.
GO; GO:0042802; F:identical protein binding; IMP:AgBase.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
GO; GO:2000483; P:negative regulation of interleukin-8 secretion; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
Gene3D; 1.10.220.10; -; 4.
InterPro; IPR001464; Annexin.
InterPro; IPR018502; Annexin_repeat.
InterPro; IPR018252; Annexin_repeat_CS.
InterPro; IPR037104; Annexin_sf.
InterPro; IPR002391; ANX4.
PANTHER; PTHR10502:SF28; PTHR10502:SF28; 1.
Pfam; PF00191; Annexin; 4.
PRINTS; PR00196; ANNEXIN.
SMART; SM00335; ANX; 4.
PROSITE; PS00223; ANNEXIN; 4.
1: Evidence at protein level;
3D-structure; Acetylation; Annexin; Calcium;
Calcium/phospholipid-binding; Complete proteome;
Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P09525}.
CHAIN 2 319 Annexin A4.
/FTId=PRO_0000067480.
REPEAT 23 83 Annexin 1.
REPEAT 95 155 Annexin 2.
REPEAT 179 239 Annexin 3.
REPEAT 254 314 Annexin 4.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P09525}.
MOD_RES 7 7 Phosphothreonine.
{ECO:0000250|UniProtKB:P08132}.
MOD_RES 12 12 Phosphoserine.
{ECO:0000250|UniProtKB:P09525}.
MOD_RES 213 213 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09525}.
MOD_RES 293 293 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09525}.
MOD_RES 300 300 N6-acetyllysine.
{ECO:0000250|UniProtKB:P09525}.
CONFLICT 95 95 L -> V (in Ref. 2; BAA11243).
{ECO:0000305}.
CONFLICT 198 198 C -> Y (in Ref. 4; AA sequence).
{ECO:0000305}.
CONFLICT 211 211 E -> K (in Ref. 2; BAA11243).
{ECO:0000305}.
HELIX 16 27 {ECO:0000244|PDB:1I4A}.
STRAND 28 31 {ECO:0000244|PDB:1I4A}.
HELIX 34 41 {ECO:0000244|PDB:1I4A}.
HELIX 46 60 {ECO:0000244|PDB:1I4A}.
HELIX 64 71 {ECO:0000244|PDB:1I4A}.
HELIX 74 84 {ECO:0000244|PDB:1I4A}.
HELIX 87 99 {ECO:0000244|PDB:1I4A}.
STRAND 100 103 {ECO:0000244|PDB:1I4A}.
HELIX 106 115 {ECO:0000244|PDB:1I4A}.
HELIX 118 132 {ECO:0000244|PDB:1I4A}.
HELIX 136 143 {ECO:0000244|PDB:1I4A}.
HELIX 146 156 {ECO:0000244|PDB:1I4A}.
HELIX 168 181 {ECO:0000244|PDB:1I4A}.
TURN 184 186 {ECO:0000244|PDB:1ANN}.
HELIX 190 199 {ECO:0000244|PDB:1I4A}.
HELIX 202 216 {ECO:0000244|PDB:1I4A}.
HELIX 220 227 {ECO:0000244|PDB:1I4A}.
HELIX 230 258 {ECO:0000244|PDB:1I4A}.
STRAND 259 262 {ECO:0000244|PDB:1I4A}.
HELIX 265 275 {ECO:0000244|PDB:1I4A}.
TURN 276 278 {ECO:0000244|PDB:1I4A}.
HELIX 280 291 {ECO:0000244|PDB:1I4A}.
HELIX 295 302 {ECO:0000244|PDB:1I4A}.
HELIX 305 315 {ECO:0000244|PDB:1I4A}.
SEQUENCE 319 AA; 35889 MW; A795DD72B0EE961F CRC64;
MAAKGGTVKA ASGFNAAEDA QTLRKAMKGL GTDEDAIINV LAYRSTAQRQ EIRTAYKTTI
GRDLMDDLKS ELSGNFEQVI LGMMTPTVLY DVQELRKAMK GAGTDEGCLI EILASRTPEE
IRRINQTYQL QYGRSLEDDI RSDTSFMFQR VLVSLSAGGR DESNYLDDAL MRQDAQDLYE
AGEKKWGTDE VKFLTVLCSR NRNHLLHVFD EYKRIAQKDI EQSIKSETSG SFEDALLAIV
KCMRNKSAYF AERLYKSMKG LGTDDDTLIR VMVSRAEIDM LDIRANFKRL YGKSLYSFIK
GDTSGDYRKV LLILCGGDD


Related products :

Catalog number Product name Quantity
U1731b CLIA 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Bos taurus,Bovine,Carbohydrate-binding protein p33_p41,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Placental anticoagulant 96T
E1731b ELISA 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Bos taurus,Bovine,Carbohydrate-binding protein p33_p41,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Placental anticoagulant 96T
U1731h CLIA 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Carbohydrate-binding protein p33_p41,Chromobindin-4,Endonexin I,Homo sapiens,Human,Lipocortin IV,P32.5,PAP-II,Placental anticoagulant 96T
10-664-50003 Annexin A4 - Annexin IV; Lipocortin IV; Endonexin I; Chromobindin-4; Protein II; P32.5; Placental anticoagulant protein II; PAP-II; PP4-X; 35-beta calcimedin; Carbohydrate-binding protein P33_P41; P33 0.025 mg
18-003-42822 Annexin A4 - Annexin IV; Lipocortin IV; Endonexin I; Chromobindin-4; Protein II; P32.5; Placental anticoagulant protein II; PAP-II; PP4-X; 35-beta calcimedin; Carbohydrate-binding protein P33_P41; P33 0.1 mg Protein A
E1731b ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Bos taurus,Bovine,Carbohydrate-binding protein p33_p41,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Placental anticoag 96T
U1731p CLIA 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Pig,Placental anticoagulant protein II,PP4-X,Protein II,Sus scrofa 96T
E1731p ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Pig,Placental anticoagulant protein II,PP4-X,Protein II,Sus scrofa 96T
E1731p ELISA 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Pig,Placental anticoagulant protein II,PP4-X,Protein II,Sus scrofa 96T
E1731h ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Carbohydrate-binding protein p33_p41,Chromobindin-4,Endonexin I,Homo sapiens,Human,Lipocortin IV,P32.5,PAP-II,Placental anticoa 96T
E1731h ELISA 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Carbohydrate-binding protein p33_p41,Chromobindin-4,Endonexin I,Homo sapiens,Human,Lipocortin IV,P32.5,PAP-II,Placental anticoagulan 96T
U0259m CLIA Anchorin CII,Annexin A5,Annexin V,Annexin-5,Anx5,Anxa5,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,Mouse,Mus musculus,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I, 96T
U0259r CLIA Anchorin CII,Annexin A5,Annexin V,Annexin-5,Anx5,Anxa5,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I,PP4,Rat,Rattus norv 96T
U0259b CLIA Anchorin CII,Annexin A5,Annexin V,Annexin-5,ANX5,ANXA5,Bos taurus,Bovine,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I,T 96T
E0259m ELISA Anchorin CII,Annexin A5,Annexin V,Annexin-5,Anx5,Anxa5,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,Mouse,Mus musculus,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I 96T
E0259b ELISA Anchorin CII,Annexin A5,Annexin V,Annexin-5,ANX5,ANXA5,Bos taurus,Bovine,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I, 96T
E0259r ELISA kit Anchorin CII,Annexin A5,Annexin V,Annexin-5,Anx5,Anxa5,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I,PP4,Rat,Rattu 96T
E0259r ELISA Anchorin CII,Annexin A5,Annexin V,Annexin-5,Anx5,Anxa5,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant protein I,PP4,Rat,Rattus nor 96T
E0259b ELISA kit Anchorin CII,Annexin A5,Annexin V,Annexin-5,ANX5,ANXA5,Bos taurus,Bovine,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant prote 96T
E0259m ELISA kit Anchorin CII,Annexin A5,Annexin V,Annexin-5,Anx5,Anxa5,Calphobindin I,CBP-I,Endonexin II,Lipocortin V,Mouse,Mus musculus,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant prot 96T
E0259h ELISA kit Anchorin CII,Annexin A5,Annexin V,Annexin-5,ANX5,ANXA5,Calphobindin I,CBP-I,Endonexin II,ENX2,Homo sapiens,Human,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant 96T
U0259h CLIA Anchorin CII,Annexin A5,Annexin V,Annexin-5,ANX5,ANXA5,Calphobindin I,CBP-I,Endonexin II,ENX2,Homo sapiens,Human,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant prote 96T
E0259h ELISA Anchorin CII,Annexin A5,Annexin V,Annexin-5,ANX5,ANXA5,Calphobindin I,CBP-I,Endonexin II,ENX2,Homo sapiens,Human,Lipocortin V,PAP-I,Placental anticoagulant protein 4,Placental anticoagulant prot 96T
18-272-196776 Annexin II - Rabbit polyclonal to Annexin II; Annexin-2; Annexin II; Lipocortin II; Calpactin I heavy chain; Chromobindin-8; p36; Protein I; Placental anticoagulant protein IV; PAP-IV Polyclonal 0.1 mg
10-664-50002 Annexin A3 - Annexin III; Lipocortin III; Placental anticoagulant protein III; PAP-III; 35-alpha calcimedin; Inositol 1.2-cyclic phosphate 2-phosphohydrolase N_A 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur