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Anoctamin-10 (Transmembrane protein 16K)

 ANO10_MOUSE             Reviewed;         659 AA.
Q8BH79; Q4FZD2; Q8BMS8; Q8BV74; Q8BW67; Q8R0U0; Q99LP0;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
12-SEP-2018, entry version 109.
RecName: Full=Anoctamin-10;
AltName: Full=Transmembrane protein 16K;
Name=Ano10; Synonyms=Tmem16k;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 193-659 (ISOFORM 4).
STRAIN=C57BL/6J, and Czech II;
TISSUE=Adipose tissue, Corpora quadrigemina, Oviduct, and Spinal cord;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=FVB/N; TISSUE=Kidney, Mammary tumor, and Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
DEVELOPMENTAL STAGE.
PubMed=18729231; DOI=10.1002/dvdy.21676;
Rock J.R., Harfe B.D.;
"Expression of TMEM16 paralogs during murine embryogenesis.";
Dev. Dyn. 237:2566-2574(2008).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
TISSUE SPECIFICITY.
PubMed=20056604; DOI=10.1074/jbc.M109.065367;
Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
Martins J.R., Kunzelmann K.;
"Expression and function of epithelial anoctamins.";
J. Biol. Chem. 285:7838-7845(2010).
[6]
REVIEW.
PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
Winpenny J.P., Gray M.A.;
"The anoctamin (TMEM16) gene family: calcium-activated chloride
channels come of age.";
Exp. Physiol. 97:175-176(2012).
-!- FUNCTION: Does not exhibit calcium-activated chloride channel
(CaCC) activity. Can inhibit the activity of ANO1 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Note=Shows predominantly an
intracellular localization with a weak expression in the cell
membrane. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=Q8BH79-1; Sequence=Displayed;
Name=2;
IsoId=Q8BH79-2; Sequence=VSP_026034;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q8BH79-3; Sequence=VSP_026035, VSP_026036;
Note=No experimental confirmation available.;
Name=4;
IsoId=Q8BH79-4; Sequence=VSP_026037;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Predominant expression seen in epithelial
tissues. {ECO:0000269|PubMed:20056604}.
-!- DEVELOPMENTAL STAGE: Detected in the mantle layer of the neural
tube and in the dorsal root ganglia at E14.5.
{ECO:0000269|PubMed:18729231}.
-!- MISCELLANEOUS: The term 'anoctamin' was coined because these
channels are anion selective and have eight (OCT) transmembrane
segments. There is some dissatisfaction in the field with the Ano
nomenclature because it is not certain that all the members of
this family are anion channels or have the 8-transmembrane
topology.
-!- SIMILARITY: Belongs to the anoctamin family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH26421.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
Sequence=BAC25927.1; Type=Frameshift; Positions=579; Evidence={ECO:0000305};
Sequence=BAC37706.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AK028391; BAC25927.1; ALT_SEQ; mRNA.
EMBL; AK046091; BAC32601.1; -; mRNA.
EMBL; AK054163; BAC35676.1; -; mRNA.
EMBL; AK079622; BAC37706.1; ALT_INIT; mRNA.
EMBL; AK080947; BAC38086.1; -; mRNA.
EMBL; BC002294; AAH02294.1; -; mRNA.
EMBL; BC026421; AAH26421.1; ALT_SEQ; mRNA.
EMBL; BC099688; AAH99688.1; -; mRNA.
CCDS; CCDS23645.1; -. [Q8BH79-1]
RefSeq; NP_001258802.1; NM_001271873.1. [Q8BH79-2]
RefSeq; NP_598740.1; NM_133979.3. [Q8BH79-1]
RefSeq; XP_011241230.1; XM_011242928.2. [Q8BH79-4]
UniGene; Mm.87676; -.
ProteinModelPortal; Q8BH79; -.
IntAct; Q8BH79; 1.
STRING; 10090.ENSMUSP00000045214; -.
PhosphoSitePlus; Q8BH79; -.
PaxDb; Q8BH79; -.
PeptideAtlas; Q8BH79; -.
PRIDE; Q8BH79; -.
Ensembl; ENSMUST00000042546; ENSMUSP00000045214; ENSMUSG00000037949. [Q8BH79-1]
Ensembl; ENSMUST00000214409; ENSMUSP00000151189; ENSMUSG00000037949. [Q8BH79-2]
Ensembl; ENSMUST00000216670; ENSMUSP00000150161; ENSMUSG00000037949. [Q8BH79-3]
GeneID; 102566; -.
KEGG; mmu:102566; -.
UCSC; uc009ser.2; mouse. [Q8BH79-1]
UCSC; uc009ses.2; mouse. [Q8BH79-2]
UCSC; uc009seu.1; mouse. [Q8BH79-4]
CTD; 55129; -.
MGI; MGI:2143103; Ano10.
eggNOG; KOG2513; Eukaryota.
eggNOG; ENOG410XPYE; LUCA.
GeneTree; ENSGT00760000119015; -.
HOVERGEN; HBG071385; -.
InParanoid; Q8BH79; -.
KO; K19327; -.
OMA; DTWYTRF; -.
OrthoDB; EOG091G06A3; -.
PhylomeDB; Q8BH79; -.
TreeFam; TF314265; -.
Reactome; R-MMU-2672351; Stimuli-sensing channels.
PRO; PR:Q8BH79; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000037949; Expressed in 228 organ(s), highest expression level in interventricular septum.
ExpressionAtlas; Q8BH79; baseline and differential.
Genevisible; Q8BH79; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0005227; F:calcium activated cation channel activity; ISO:MGI.
GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
GO; GO:0006812; P:cation transport; ISO:MGI.
GO; GO:0006821; P:chloride transport; ISO:MGI.
InterPro; IPR007632; Anoctamin.
InterPro; IPR031291; Anoctamin-10.
PANTHER; PTHR12308; PTHR12308; 1.
PANTHER; PTHR12308:SF40; PTHR12308:SF40; 1.
Pfam; PF04547; Anoctamin; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome; Membrane;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 659 Anoctamin-10.
/FTId=PRO_0000289958.
TOPO_DOM 1 207 Cytoplasmic. {ECO:0000255}.
TRANSMEM 208 228 Helical. {ECO:0000255}.
TOPO_DOM 229 240 Extracellular. {ECO:0000255}.
TRANSMEM 241 261 Helical. {ECO:0000255}.
TOPO_DOM 262 316 Cytoplasmic. {ECO:0000255}.
TRANSMEM 317 337 Helical. {ECO:0000255}.
TOPO_DOM 338 352 Extracellular. {ECO:0000255}.
TRANSMEM 353 373 Helical. {ECO:0000255}.
TOPO_DOM 374 400 Cytoplasmic. {ECO:0000255}.
TRANSMEM 401 421 Helical. {ECO:0000255}.
TOPO_DOM 422 500 Extracellular. {ECO:0000255}.
TRANSMEM 501 521 Helical. {ECO:0000255}.
TOPO_DOM 522 553 Cytoplasmic. {ECO:0000255}.
TRANSMEM 554 574 Helical. {ECO:0000255}.
TOPO_DOM 575 590 Extracellular. {ECO:0000255}.
TRANSMEM 591 611 Helical. {ECO:0000255}.
TOPO_DOM 612 659 Cytoplasmic. {ECO:0000255}.
VAR_SEQ 198 255 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_026034.
VAR_SEQ 600 612 HALLALKFILAFA -> VLGLQASFTIGFY (in
isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_026035.
VAR_SEQ 613 659 Missing (in isoform 3).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_026036.
VAR_SEQ 639 659 QMKLVAENLKEEYQEDGKEAT -> VRAVCLETLLDYIPLA
QAPSHCVSFSMDLSVK (in isoform 4).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_026037.
SEQUENCE 659 AA; 76188 MW; 435D9A08D48F93FC CRC64;
MRVTLSTLDT CESSFTPLVV IELAQDVKDE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE
KETLENQNLY LVGASNVRLL LGAEAVGLVK ECTDAAMRAF TYGTRHNFKG FHDNNNDFLT
MAECQFIIKH ELENLRARDE KMIPGYPQAK LYPGKSLMRR LLTSGIVTQV FPLHDTEALK
KLEDTWYTRF ALKYQPIDSI RSYFGETIAL YFGFLEYFTF ALIPMAIIGL PYYLFVWEDY
DKYVIFASFN LIWSTVILEV WKRGCANMTY RWGTLVMKRQ FEEPRPGFHG VLGINSVTGR
EEPLYSSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME DWALSLHEDS GSEWTSLLLY
VPSIVYAVVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL VLKVLVFNFL NCFASLFYIA
FVLKDMKLLR QSLATLLITS QILNQVVESL LPYWLQRKYC ARVKRKVQAL KSEVDTTLYE
QVLLEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV
FKRPFAEPSA SIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKTD LVLIVVAVEH
ALLALKFILA FAIPDKPRHI QQKLARLEFE SLEALKQQQM KLVAENLKEE YQEDGKEAT


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