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Anoctamin-3 (Transmembrane protein 16C)

 ANO3_MOUSE              Reviewed;         981 AA.
A2AHL1; A2AHL0;
04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
05-FEB-2008, sequence version 1.
20-JUN-2018, entry version 79.
RecName: Full=Anoctamin-3 {ECO:0000250|UniProtKB:Q9BYT9};
AltName: Full=Transmembrane protein 16C {ECO:0000312|EMBL:CAM25697.1};
Name=Ano3 {ECO:0000250|UniProtKB:Q9BYT9};
Synonyms=Tmem16c {ECO:0000312|EMBL:CAM25697.1,
ECO:0000312|MGI:MGI:3613666};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2] {ECO:0000305}
DEVELOPMENTAL STAGE.
PubMed=18729231; DOI=10.1002/dvdy.21676;
Rock J.R., Harfe B.D.;
"Expression of TMEM16 paralogs during murine embryogenesis.";
Dev. Dyn. 237:2566-2574(2008).
[3]
TISSUE SPECIFICITY.
PubMed=20056604; DOI=10.1074/jbc.M109.065367;
Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
Martins J.R., Kunzelmann K.;
"Expression and function of epithelial anoctamins.";
J. Biol. Chem. 285:7838-7845(2010).
[4]
REVIEW.
PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
Winpenny J.P., Gray M.A.;
"The anoctamin (TMEM16) gene family: calcium-activated chloride
channels come of age.";
Exp. Physiol. 97:175-176(2012).
[5]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=23532839; DOI=10.1074/jbc.M113.457937;
Suzuki J., Fujii T., Imao T., Ishihara K., Kuba H., Nagata S.;
"Calcium-dependent phospholipid scramblase activity of TMEM16 protein
family members.";
J. Biol. Chem. 288:13305-13316(2013).
[6]
FUNCTION, AND INTERACTION WITH KCNT1.
PubMed=23872594; DOI=10.1038/nn.3468;
Huang F., Wang X., Ostertag E.M., Nuwal T., Huang B., Jan Y.N.,
Basbaum A.I., Jan L.Y.;
"TMEM16C facilitates Na(+)-activated K+ currents in rat sensory
neurons and regulates pain processing.";
Nat. Neurosci. 16:1284-1290(2013).
-!- FUNCTION: Has calcium-dependent phospholipid scramblase activity;
scrambles phosphatidylcholine and galactosylceramide. Does not
exhibit calcium-activated chloride channel (CaCC) activity. Seems
to act as potassium channel regulator and may inhibit pain
signaling; can facilitate KCNT1/Slack channel activity by
promoting its full single-channel conductance at very low sodium
concentrations and by increasing its sodium sensitivity.
{ECO:0000269|PubMed:23532839, ECO:0000269|PubMed:23872594}.
-!- SUBUNIT: Interacts with KCNT1/Slack.
{ECO:0000269|PubMed:23872594}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
membrane protein {ECO:0000255}. Note=Shows an intracellular
localization. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=A2AHL1-1; Sequence=Displayed;
Name=2;
IsoId=A2AHL1-2; Sequence=VSP_052958, VSP_052959;
Note=Gene prediction based on EST data. {ECO:0000305};
-!- TISSUE SPECIFICITY: Predominantly expressed in neuronal tissues.
Expressed in brain. {ECO:0000269|PubMed:20056604,
ECO:0000269|PubMed:23532839}.
-!- DEVELOPMENTAL STAGE: In the developing gastrointestinal tract,
expressed in the intestinal epithelium at E14.5 and in an
incomplete ring of cells in the mesenchyme of the esophagus,
stomach and small intestine at E16.5. In the developing skeleton,
expressed in the perichondria of the neural arch of developing
vertebrae at E14.5 and E16.5. At E14.5, also expressed in
perichondria of developing ribs. At E14.5 and E16.5, detected in
dorsal root ganglia and neural tube. In developing skin,
expression is detected in the most suprabasal layers at E16.5. Not
detected in the lung at E14.5 or E16.5.
{ECO:0000269|PubMed:18729231}.
-!- MISCELLANEOUS: The term 'anoctamin' was coined because these
channels are anion selective and have eight (OCT) transmembrane
segments. There is some dissatisfaction in the field with the Ano
nomenclature because it is not certain that all the members of
this family are anion channels or have the 8-transmembrane
topology.
-!- SIMILARITY: Belongs to the anoctamin family.
{ECO:0000250|UniProtKB:Q9BYT9}.
-----------------------------------------------------------------------
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EMBL; AL731700; CAM18324.1; -; Genomic_DNA.
EMBL; AL731779; CAM18324.1; JOINED; Genomic_DNA.
EMBL; AL731700; CAM18325.1; -; Genomic_DNA.
EMBL; AL731779; CAM18325.1; JOINED; Genomic_DNA.
EMBL; BX005257; CAM18325.1; JOINED; Genomic_DNA.
EMBL; AL731779; CAM25696.1; -; Genomic_DNA.
EMBL; AL731700; CAM25696.1; JOINED; Genomic_DNA.
EMBL; AL731779; CAM25697.1; -; Genomic_DNA.
EMBL; AL731700; CAM25697.1; JOINED; Genomic_DNA.
EMBL; BX005257; CAM25697.1; JOINED; Genomic_DNA.
EMBL; BX005257; CAM27817.1; -; Genomic_DNA.
EMBL; AL731700; CAM27817.1; JOINED; Genomic_DNA.
EMBL; AL731779; CAM27817.1; JOINED; Genomic_DNA.
CCDS; CCDS50658.1; -. [A2AHL1-1]
RefSeq; NP_001121575.1; NM_001128103.2. [A2AHL1-1]
UniGene; Mm.483325; -.
ProteinModelPortal; A2AHL1; -.
STRING; 10090.ENSMUSP00000097219; -.
SwissLipids; SLP:000000377; -.
iPTMnet; A2AHL1; -.
PhosphoSitePlus; A2AHL1; -.
PaxDb; A2AHL1; -.
PRIDE; A2AHL1; -.
Ensembl; ENSMUST00000099623; ENSMUSP00000097219; ENSMUSG00000074968. [A2AHL1-1]
GeneID; 228432; -.
KEGG; mmu:228432; -.
UCSC; uc008lmy.1; mouse. [A2AHL1-2]
UCSC; uc012caw.2; mouse. [A2AHL1-1]
CTD; 63982; -.
MGI; MGI:3613666; Ano3.
eggNOG; KOG2514; Eukaryota.
eggNOG; ENOG410XS4S; LUCA.
GeneTree; ENSGT00760000119015; -.
HOGENOM; HOG000006509; -.
HOVERGEN; HBG069519; -.
InParanoid; A2AHL1; -.
KO; K19498; -.
OMA; CKLINNG; -.
OrthoDB; EOG091G01JF; -.
PhylomeDB; A2AHL1; -.
TreeFam; TF314265; -.
Reactome; R-MMU-2672351; Stimuli-sensing channels.
ChiTaRS; Ano3; mouse.
PRO; PR:A2AHL1; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000074968; -.
ExpressionAtlas; A2AHL1; baseline and differential.
Genevisible; A2AHL1; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0017128; F:phospholipid scramblase activity; IDA:MGI.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0061591; P:calcium activated galactosylceramide scrambling; IDA:MGI.
GO; GO:0061590; P:calcium activated phosphatidylcholine scrambling; IDA:MGI.
GO; GO:0050982; P:detection of mechanical stimulus; ISO:MGI.
GO; GO:0016048; P:detection of temperature stimulus; ISO:MGI.
InterPro; IPR032394; Anoct_dimer.
InterPro; IPR007632; Anoctamin.
InterPro; IPR031292; Anoctamin-3.
PANTHER; PTHR12308; PTHR12308; 1.
PANTHER; PTHR12308:SF16; PTHR12308:SF16; 1.
Pfam; PF16178; Anoct_dimer; 1.
Pfam; PF04547; Anoctamin; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome; Glycoprotein;
Lipid transport; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 981 Anoctamin-3.
/FTId=PRO_0000353188.
TOPO_DOM 1 403 Cytoplasmic. {ECO:0000255}.
TRANSMEM 404 424 Helical. {ECO:0000255}.
TOPO_DOM 425 469 Extracellular. {ECO:0000255}.
TRANSMEM 470 490 Helical. {ECO:0000255}.
TOPO_DOM 491 550 Cytoplasmic. {ECO:0000255}.
TRANSMEM 551 571 Helical. {ECO:0000255}.
TOPO_DOM 572 592 Extracellular. {ECO:0000255}.
TRANSMEM 593 613 Helical. {ECO:0000255}.
TOPO_DOM 614 640 Cytoplasmic. {ECO:0000255}.
TRANSMEM 641 661 Helical. {ECO:0000255}.
TOPO_DOM 662 761 Extracellular. {ECO:0000255}.
TRANSMEM 762 782 Helical. {ECO:0000255}.
TOPO_DOM 783 810 Cytoplasmic. {ECO:0000255}.
TRANSMEM 811 831 Helical. {ECO:0000255}.
TOPO_DOM 832 914 Extracellular. {ECO:0000255}.
TRANSMEM 915 935 Helical. {ECO:0000255}.
TOPO_DOM 936 981 Cytoplasmic. {ECO:0000255}.
CARBOHYD 425 425 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 448 448 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 455 455 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 866 866 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 625 637 EYPRTESEWENSF -> GKFIFLILLVVSK (in
isoform 2). {ECO:0000305}.
/FTId=VSP_052958.
VAR_SEQ 638 981 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_052959.
SEQUENCE 981 AA; 114568 MW; E851D80BC49F4977 CRC64;
MVHHSGSIQS FKQQKGMNIS KSEITTEASL KPSRRSLPCL AQSYAHSKSL SQSASLFQST
ESESQAPTSV TFLSADKPEH VTSEESRKDS TLKCSFADLS DFCLALGKDK DYLDESEHAN
YDRSRLLNDF VTKDKPASKT KLSKNDMSYI ASSGLLFKDG KKRIDYILVY RKTNIQYDKR
NTFEKNLRAE GLMLEKEPAI ANPDIMFIKI HIPWDTLCKY AERLNIRVPF RKKCYYTDQK
NKSKSRVQNY FKRIKKWMSQ NPMVLDKSAF PELEESDCYT GPFSRARIHH FIINNKDTFF
SNATRSRIVY HMLERTKYEN GISKVGIRKL ITNGSYIAAF PPHEGAYKSS LPIKTHGPQN
NRHLLYERWA RWGMWYKHQP LDLIRMYFGE KIGLYFAWLG WYTGMLIPAA VVGLCVFFYG
LVTMNESQVS QEICKATEVF MCPLCDKNCS LQRLNDSCIY AKVTYLFDNG GTVFFAIFMA
IWATVFLEFW KRRRSILTYT WDLIEWEEEE ETLRPQFEAK YYRMEVINPI TGKPEPHQPS
SDKVTRLLVS VSGIFFMISL VITAVFAVVV YRLVVMEQFA SFKWNFVKQH WQFATSGAAV
CINFIIIMLL NLAYEKIAYL LTNLEYPRTE SEWENSFALK MFLFQFVNLN SSIFYIAFFL
GRFVGHPGKY NKLFERWRLE ECHPSGCLID LCLQMGVIMF LKQIWNNFME LGYPLIQNWW
SRHKIKRGIQ DASIPQWEND WNLQPMNIHG LMDEYLEMVL QFGFTTIFVA AFPLAPLLAL
LNNIIEIRLD AYKFVTQWRR PLPARATDIG IWLGILEGIG ILAVITNAFV IAITSDYIPR
FVYEYKYGPC ANHVKQNENC LKGYVNNSLS FFDLSELGMG KSGYCRYRDY RGPPWSSKPY
EFTLQYWHIL AARLAFIIVF EHLVFGIKSF IAYLIPDIPK GLRERIRREK YLVQEMMYEA
ELEHLQQQRR KSGQPIHHEW P


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