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Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G)

 ANO7_MOUSE              Reviewed;         859 AA.
Q14AT5; Q6IFT5;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
29-MAY-2007, sequence version 2.
12-SEP-2018, entry version 86.
RecName: Full=Anoctamin-7;
AltName: Full=New gene expressed in prostate homolog;
AltName: Full=Transmembrane protein 16G;
Name=Ano7; Synonyms=Ngep, Tmem16g;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION.
PubMed=14981236; DOI=10.1073/pnas.0308746101;
Bera T.K., Das S., Maeda H., Beers R., Wolfgang C.D., Kumar V.,
Hahn Y., Lee B., Pastan I.;
"NGEP, a gene encoding a membrane protein detected only in prostate
cancer and normal prostate.";
Proc. Natl. Acad. Sci. U.S.A. 101:3059-3064(2004).
[4]
TISSUE SPECIFICITY.
PubMed=20056604; DOI=10.1074/jbc.M109.065367;
Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M.,
Martins J.R., Kunzelmann K.;
"Expression and function of epithelial anoctamins.";
J. Biol. Chem. 285:7838-7845(2010).
[5]
REVIEW.
PubMed=22302790; DOI=10.1113/expphysiol.2011.058214;
Winpenny J.P., Gray M.A.;
"The anoctamin (TMEM16) gene family: calcium-activated chloride
channels come of age.";
Exp. Physiol. 97:175-176(2012).
[6]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=23532839; DOI=10.1074/jbc.M113.457937;
Suzuki J., Fujii T., Imao T., Ishihara K., Kuba H., Nagata S.;
"Calcium-dependent phospholipid scramblase activity of TMEM16 protein
family members.";
J. Biol. Chem. 288:13305-13316(2013).
-!- FUNCTION: Has calcium-dependent phospholipid scramblase activity;
scrambles phosphatidylserine, phosphatidylcholine and
galactosylceramide. Does not exhibit calcium-activated chloride
channel (CaCC) activity. May play a role in cell-cell
interactions. {ECO:0000269|PubMed:23532839}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q6IWH7}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:Q6IWH7}. Endoplasmic reticulum
{ECO:0000250|UniProtKB:Q6IWH7}. Note=Concentrates at sites of
cell-cell contact. Shows an intracellular localization.
{ECO:0000250|UniProtKB:Q6IWH7}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q14AT5-1; Sequence=Displayed;
Name=2;
IsoId=Q14AT5-2; Sequence=VSP_026009, VSP_026010;
-!- TISSUE SPECIFICITY: Highly expressed in the stomach. Expressed at
low levels in small intestine and large intestine.
{ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:23532839}.
-!- MISCELLANEOUS: The term 'anoctamin' was coined because these
channels are anion selective and have eight (OCT) transmembrane
segments. There is some dissatisfaction in the field with the Ano
nomenclature because it is not certain that all the members of
this family are anion channels or have the 8-transmembrane
topology.
-!- SIMILARITY: Belongs to the anoctamin family. {ECO:0000305}.
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EMBL; AC108412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC124669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC116706; AAI16707.1; -; mRNA.
EMBL; BK004075; DAA04566.1; -; mRNA.
CCDS; CCDS15188.1; -. [Q14AT5-1]
CCDS; CCDS78656.1; -. [Q14AT5-2]
RefSeq; NP_001258813.1; NM_001271884.1. [Q14AT5-2]
RefSeq; NP_996914.1; NM_207031.2. [Q14AT5-1]
RefSeq; XP_006529796.1; XM_006529733.2. [Q14AT5-1]
UniGene; Mm.297411; -.
ProteinModelPortal; Q14AT5; -.
STRING; 10090.ENSMUSP00000050495; -.
SwissLipids; SLP:000000375; -.
iPTMnet; Q14AT5; -.
PhosphoSitePlus; Q14AT5; -.
PaxDb; Q14AT5; -.
PRIDE; Q14AT5; -.
Ensembl; ENSMUST00000058682; ENSMUSP00000050495; ENSMUSG00000034107. [Q14AT5-2]
Ensembl; ENSMUST00000186641; ENSMUSP00000140438; ENSMUSG00000034107. [Q14AT5-1]
GeneID; 404545; -.
KEGG; mmu:404545; -.
UCSC; uc007cdw.2; mouse. [Q14AT5-1]
UCSC; uc033fku.1; mouse. [Q14AT5-2]
CTD; 50636; -.
MGI; MGI:3052714; Ano7.
eggNOG; KOG2514; Eukaryota.
eggNOG; ENOG410XS4S; LUCA.
GeneTree; ENSGT00760000119015; -.
HOGENOM; HOG000006509; -.
HOVERGEN; HBG069519; -.
InParanoid; Q14AT5; -.
KO; K19501; -.
OMA; ILAKTPY; -.
OrthoDB; EOG091G01JF; -.
PhylomeDB; Q14AT5; -.
TreeFam; TF314265; -.
Reactome; R-MMU-2672351; Stimuli-sensing channels.
PRO; PR:Q14AT5; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000034107; Expressed in 18 organ(s), highest expression level in colon.
ExpressionAtlas; Q14AT5; baseline and differential.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IDA:MGI.
GO; GO:0017128; F:phospholipid scramblase activity; IDA:MGI.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0061591; P:calcium activated galactosylceramide scrambling; IDA:MGI.
GO; GO:0061590; P:calcium activated phosphatidylcholine scrambling; IDA:MGI.
GO; GO:0061589; P:calcium activated phosphatidylserine scrambling; IDA:MGI.
GO; GO:0006821; P:chloride transport; IDA:MGI.
InterPro; IPR032394; Anoct_dimer.
InterPro; IPR007632; Anoctamin.
InterPro; IPR031296; Anoctamin-7.
PANTHER; PTHR12308; PTHR12308; 1.
PANTHER; PTHR12308:SF22; PTHR12308:SF22; 1.
Pfam; PF16178; Anoct_dimer; 1.
Pfam; PF04547; Anoctamin; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome;
Endoplasmic reticulum; Glycoprotein; Lipid transport; Membrane;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 859 Anoctamin-7.
/FTId=PRO_0000289327.
TOPO_DOM 1 297 Cytoplasmic. {ECO:0000255}.
TRANSMEM 298 318 Helical. {ECO:0000255}.
TOPO_DOM 319 362 Extracellular. {ECO:0000255}.
TRANSMEM 363 383 Helical. {ECO:0000255}.
TOPO_DOM 384 441 Cytoplasmic. {ECO:0000255}.
TRANSMEM 442 462 Helical. {ECO:0000255}.
TOPO_DOM 463 492 Extracellular. {ECO:0000255}.
TRANSMEM 493 513 Helical. {ECO:0000255}.
TOPO_DOM 514 530 Cytoplasmic. {ECO:0000255}.
TRANSMEM 531 551 Helical. {ECO:0000255}.
TOPO_DOM 552 651 Extracellular. {ECO:0000255}.
TRANSMEM 652 672 Helical. {ECO:0000255}.
TOPO_DOM 673 700 Cytoplasmic. {ECO:0000255}.
TRANSMEM 701 721 Helical. {ECO:0000255}.
TOPO_DOM 722 780 Extracellular. {ECO:0000255}.
TRANSMEM 781 801 Helical. {ECO:0000255}.
TOPO_DOM 802 859 Cytoplasmic. {ECO:0000255}.
CARBOHYD 746 746 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 761 761 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 836 843 ALLGATGV -> VTVGVTGG (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_026009.
VAR_SEQ 844 859 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_026010.
SEQUENCE 859 AA; 97128 MW; 82E1A473C59C8DA3 CRC64;
MLRGQAREED SVVLIDMASP EAGNGCSYGS TAQASEAGKQ QVAPSRVGSS AKPPIDFVLV
WEEDLRNQEN PTKDKTDTHE VWRETFLENL CLAGLKIDQH DVQDEAAAVH YILLRAPWAV
LCYYAEDLRL KLPLQELPNQ ASNWSATLLE WLGIPNILLE HVPDTPPEYY SCQFKASKLQ
WFLGSDNQDT FFTSTKRHQI LFEILAKTPY GHEKKGLFGI DQLLAEGVFS AAFPLHDGPF
SAVPESSQVL GLIQRQVLFQ HWARWGKWNK YQPLDHVRRY FGEKVALYFA WLGFYTGWLL
PAAVVGTVVF LVGCFLVFSD IPTQELCHSS DSFDMCPLCS DCSFWLLSSA CTLAQAGRLF
DHGGTVFFSL FMALWAVLLL EYWKRKNATL AYRWDCSDYE DIEERPRPQF AATAPMTALN
PITGEDEPYF PEKNRVRRML AGSVVLLMMV AVVIMCLVSV ILYRAVMAII VSRSDNAFLS
AWASRIASLT GSVVNLVFIL ILSKVYVLLA QVLTRWEMHR TQTEFEDAFT LKVFIFQFVN
FYASPVYIAF FKGRFVGYPG NYHTLFGIRN EECPAGGCLS ELAQELLVIM VGKQIINNVQ
EVLVPKLKGC WQKFSRGKKA GTGTHPAPWE ADYELLPCEG LFHEYLEMVL QFGFVTIFVA
ACPLAPLFAL LNNWVEIRLD ARKFVCEYRR PVAERAQDIG IWFHILTGLT HLAVISNAFL
LAFSSDFLPR VYYSWTHAPD LHGFLNFTLA RAPPTFTSAH NRTCRYRAFR DDDGHYSPTY
WTLLAIRLAF VIVFEHVVFS IGRVLDLLVP DIPESVEIKV KREYYLAKQA LAENEALLGA
TGVKDDQPPS SEPSLGLPA


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